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Scientific Data — MethAgingDB: a comprehensive DNA methylation database for aging biology. MethAgingDB includes 93 datasets, with 11,474 profiles from 13 distinct human tissues and 1,361 profiles from 9 distinct mouse tissues. The database provides preprocessed DNA methylation data in a consistent matrix format, along with tissue-specific DMSs and DMRs, gene-centric aging insights, and an extensive collection of epigenetic clocks. Together, MethAgingDB is expected to streamline aging-related epigenetic research and support the development of robust, biologically informed aging biomarkers.
A four-day work week can lead to happier and more productive, dedicated employees, a new global study found.
Workers at companies that instituted a four-day work week—essentially working 80% of their regular hours for the same pay—reported less burnout and better job satisfaction along with improved mental and physical health, researchers report in Nature Human Behavior.
“Across outcomes, the magnitude (of improvement) is larger for the two work-related measures—burnout and job satisfaction—followed by mental health, with the smallest changes reported in physical health,” wrote the research team co-led by Juliet Schor, an economist and sociologist at Boston College.
At its core, psychopathy is not simply a matter of bad choices or poor upbringing — growing evidence suggests it has a biological foundation, shaped by the intricate wiring of the human brain.
Now, a new study offers fresh insights into how structural brain connectivity patterns are linked to psychopathic traits and the externalizing behaviors that often accompany them.
Colon cancer remains a major global health concern, ranking third among the most diagnosed cancers and the leading cause of cancer-related death worldwide. One critical factor that makes treating colon cancer challenging is the presence of cancer stem cells.
Though typically present in small populations, these powerful cells drive tumor growth, resist standard treatments, and often contribute to relapse. They achieve this through their “stemness,” a set of properties that enable these cells to self-renew and differentiate into other cell types. Thus, understanding how stemness might be controlled at the molecular level is essential for developing effective therapies for colon cancer.
Over the past two decades, researchers have identified several key molecules involved in both the development of the colon and the progression of colon cancer. Among them are CDX1 and CDX2, two homeobox transcription factors that help establish and maintain the identity of intestinal epithelial cells.
