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Mantle Cell Lymphoma Translocations Rewire Chromosome-Wide Gene Expression

Translocations are chromosomal “cut and paste” errors that drive many lymphomas, a type of blood cancer and the sixth most common form of cancer overall. This includes mantle cell lymphoma, a rare but aggressive subtype diagnosed in about one in every 100,000 people each year.

A study by researchers at the Centre for Genomic Regulation (CRG) in Barcelona, has shown a new way translocations promote cancer. The translocation most typically found in mantle cell lymphoma drags a powerful regulatory element into a new area of the human genome, where its new position allows it to boost the activity of not just one but 50 genes at once.

The discovery of this genome rewiring mechanism shows the traditional focus on the handful of genes at chromosomal breakpoints is too narrow. The study also greatly expands the list of potential drug targets for mantle cell lymphoma, for which there is no known cure.

Immune cells in the brain help shape adolescent neural circuits

Making a smoothie, going for an evening walk, or having empathy for a loved one are all examples of executive functions that are controlled by the brain’s frontal cortex. This area of the brain goes through profound change throughout adolescence, and it is during this time that abnormalities in maturing circuits can set the stage for neurodevelopmental disorders, such as schizophrenia and ADHD.

Researchers at the Del Monte Institute for Neuroscience at the University of Rochester have discovered that microglia, the brain’s immune cells, play a key role in how the brain adapts to the changes in this area during adolescence, which may transform how are treated during this window and, possibly, into adulthood.

“A better understanding of the ways we can drive changes in these circuits offers new targets for disease treatment,” said Rianne Stowell, Ph.D., research assistant professor of Neuroscience at the University of Rochester Medical Center, and first author of the study out today in Nature Communications.

Canaries in the Coal Mine? Six Facts about the Recent Employment Effects of Artificial Intelligence

This paper examines changes in the labor market for occupations exposed to generative artificial intelligence using high-frequency administrative data from ADP, the largest payroll software provider in the United States.

The Imbalance in Automobility Transformation

Legacy Auto’s Desperation vs. Tesla’s Dominance.

## Abstract.

In the accelerating automobility transformation, legacy automakers like Ford—grappling with $12 billion in EV losses since 2023, including $2.2 billion in H1 2025 and projections up to $5.5 billion for the year—desperately seek Tesla’s technological lifelines, yet Tesla has scant incentive to license its Full Self-Driving (FSD) system.

This report unveils the Darwinian imbalance: Tesla’s unassailable edge in 4.5 billion FSD miles (adding millions daily), propelling intelligent vehicles (IVs) to 10x safer than humans; poised to eliminate over 1 million annual global road deaths, 50 million injuries, and $4 trillion in economic damage annually.

Bolstered by vertical integration, unboxed manufacturing for sub-$30,000 Cybercabs at unprecedented rates, a 70,000+ connector Supercharger network, and robotaxi economics unlocking a $10 trillion market by 2029, Tesla dominates—hastening an 80% decline in private ownership by 2030 per Tony Seba, fostering shared fleets, urban digital twins, and integrated energy systems for sustainable communities worldwide.

Discover why legacy desperation fuels Tesla’s triumph in reshaping transportation.

[Get The Imbalance in Automobility Transformation White Paper](https://cdn.shopify.com/s/files/1/1295/2229/files/The_Imbala…756222023)

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