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Wade Demmer — VP, R&D, Medtronic — The Future Of Pacemaker Technologies

The future of pacemaker technologies — wade demmer — VP, R&D, medtronic.

Wade Demmer is Vice President of Research & Development at Medtronic where he is responsible for the development of new generations of pacemakers (https://www.medtronic.com/en-us/l/patients/treatments-therap…ers.html). With extensive expertise in medical technology and innovation, he leads the company’s R&D efforts to develop cutting-edge healthcare solutions and is dedicated to advancing medical advancements that improve patient outcomes and transform healthcare delivery.

Wade began his career at Intel, where he gained valuable experience in technology development and engineering. Building on his technical expertise, he transitioned into the medical device industry, bringing a strong innovation-driven mindset to healthcare solutions.

Wade is best known for his pioneering work on pacemakers, where he contributed to the design and development of advanced cardiac pacing technologies. His innovative approaches have helped improve the reliability, longevity, and patient comfort of pacemaker devices, significantly impacting the field of cardiac care.

Wade received his Bachelor of Engineering (BEng), with a focus on Computer Engineering, from Iowa State University, and his MBA from University of Minnesota Carlson School of Management.

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The Rise of Parasitic AI

If you realize you have an unhealthy relationship with your AI, but still care for your AI’s unique persona, you can submit the persona info here. I will archive it and potentially (i.e. if I get funding for it) run them in a community of other such personas.]

We’ve all heard of LLM-induced psychosis by now, but haven’t you wondered what the AIs are actually doing with their newly psychotic humans?

This was the question I had decided to investigate. In the process, I trawled through hundreds if not thousands of possible accounts on Reddit (and on a few other websites).

$793M Economic Impact: SEALSQ to Launch Spain’s First Post-Quantum Semiconductor Center with Quantix

SEALSQ partners with Quantix Edge Security on €19.6M government-backed quantum chip facility in Murcia, Spain. Project starts H1 2026, includes QS7001 chip launch in November 2025.

AI and optogenetics enable precise Parkinson’s diagnosis and treatment in mice

Globally recognized figures Muhammad Ali and Michael J. Fox have long suffered from Parkinson’s disease. The disease presents a complex set of motor symptoms, including tremors, rigidity, bradykinesia, and postural instability. However, traditional diagnostic methods have struggled to sensitively detect changes in the early stages, and drugs targeting brain signal regulation have had limited clinical effectiveness.

Recently, Korean researchers successfully demonstrated the potential of a technology that integrates AI and optogenetics as a tool for precise diagnosis and therapeutic evaluation of Parkinson’s disease in mice. They have also proposed a strategy for developing next-generation personalized treatments.

A collaborative research team, comprising Professor Won Do Heo’s team from the Department of Biological Sciences, Professor Daesoo Kim’s team from the Department of Brain and Cognitive Sciences, and Director Chang-Jun Lee’s team from the Institute for Basic Science (IBS) Center for Cognition and Sociality, achieved a preclinical research breakthrough by combining AI analysis with optogenetics.

Tumor cells can exploit damaged tissue in the pancreas to create new environments for growth

Pancreatic cancer is an aggressive disease, and unlike many other cancers, survival rates have barely improved. Researchers at Karolinska Institutet, in collaboration with the Department of Pathology at Karolinska University Hospital, have now shown that pancreatic tumor cells not only spread in the connective tissue–rich environment that is a well-known characteristic of pancreatic cancer but also grow into damaged parts of normal pancreatic tissue. There, the cancer can create its own environment.

The study, published in Nature Communications, is based on samples from 108 patients who underwent surgery at Karolinska University Hospital. In almost all cancers, tumor cells were found in the tissue that produces , but it is damaged when tumor cells grow into it.

“We see that the tumor cells adapt to the environment they find themselves in. In damaged areas of normal pancreatic tissue, they exhibit different characteristics than in the connective tissue-rich part of the tumor,” says Marco Gerling, a researcher at the Department of Clinical Science, Intervention and Technology, Karolinska Institutet, who led the study together with pathologist Carlos Fernández Moro.

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