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This paper suggests that ATP release induced by the SARS-CoV-2 virus plays a key role in the genesis of the major symptoms and complications of COVID-19. Infection of specific cells which contain the Angiotensin-Converting Enzyme 2 (ACE2) receptor results in a loss of protection of the Mineralocorticoid Receptor (MR). Local activation by cortisol stimulates the release of ATP initially into the basolateral compartment and then by lysosomal exocytosis from the cell surface. This then acts on adjacent cells. In the nose ATP acts as a nociceptive stimulus which results in anosmia. It is suggested that a similar paracrine mechanism is responsible for the loss of taste. In the lung ATP release from type 2 alveolar cells produces the non-productive cough by acting on purinergic receptors on adjacent neuroepithelial cells and activating, via the vagus, the cough reflex. Infection of endothelial cells results in the exocytosis of WeibelPalade bodies. These contain the Von Willebrand Factor responsible for micro-clotting and angiopoietin-2 which increases vascular permeability and plays a key role in the Acute Respiratory Distress Syndrome. To test this hypothesis this paper reports proof of concept studies in which MR blockade using spironolactone and low dose dexamethasone (SpiDex) was given to PCR-confirmed COVID-19 patients. In 80 patients with moderate to severe respiratory failure 40 were given SpiDex and 40 conventional treatment with high dose dexamethasone (HiDex). There was 1 death in the HiDex group and none in the SpiDex. As judged by clinical, biochemical and radiological parameters there were clear statistically significant benefits of SpiDex in comparison to HiDex. A further 20 outpatients with COVID-19 were given SpiDex. There was no control group and the aim was to demonstrate safety. No adverse effects were noted and no patient became hyperkalaemic. 90% were asymptomatic at 10 days. The very positive results suggest that blockade of the MR can produce major benefit in COVID19 patients. Further larger controlled studies of inpatients and outpatients are required not only for SARS-CoV-2 infection per se but also to determine if this treatment affects the incidence of Long COVID.

Early in the course of the SARS-CoV-2 pandemic it became clear that one of the commonest symptoms was loss of smell and/or taste. Self-reported alterations in smell and taste were detailed in a meta-analysis of 3,563 confirmed cases of COVID-19. They found that the overall prevalence of smell or taste impairment was 47% rising to 67% in patients with more severe disease. In about 20% of patients it was an isolated presenting symptom. Han et al. reviewed the pathophysiology of anosmia in upper respiratory tract infections. Many rhinovirus infections of the nasal olfactory epithelium produce post-viral anosmia which persists for weeks or months until the cell damage is repaired. Post-viral anosmia has been reported with HCoV-229E infection with the olfactory dysfunction lasting more than 6 months. This corona virus does not use ACE2 to get into cells. Conductive or obstructive anosmia is often found with the common cold virus.

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Circa 2018 c:

Shoes made from stone may sound uncomfortable and something the Flintstones might wear. However, thanks to innovative technology, it is possible to transform ordinary stone into a flexible and paper-thin material. German companies Roxxlyn and Nat-2 decided to work together and use this material to create the world’s first sneakers made from natural stone!

When we think about stone, we think about hard and sturdy material, rather than something flexible. However, Roxxlyn, an expert in creating ultra-light design pieces from stone, developed a technology to use stone to make all kinds of accessories and design pieces, from phone cases to belts, and now sneakers.

The process begins with slicing real stone into thin layers. When these have been extracted, they are flexible and smooth. The pieces are then machined into shape using diamond tools. The layer is engraved on the top surface using a high performance laser. The now created piece is sanded and cleaned from dust and grime by hand. Through a complicated technology, stone slates are made flexible.

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Limitless Space Institute gave out nine interstellar space-related grants for about $1 million to 2 million each. Phil Lubin’s direct laser propulsion group received a grant and they will use to prove out their directed laser propulsion system at the 10–20 watt level. They are also working on components at the kilowatt to tens of kilowatt level. The plan would be to scale to tens of kilowatts and work towards power beaming to the moon for experiments. In 5–10 years, they hope to reach megawatt levels.

If they reach 500 megawatts then direct laser propulsion could be used for 30 day transit times to Mars. When the system scales to the gigawatt or tens of gigawatt level with a matching deceleration and launching system on Mars this would enable 2.5 day transit times between Earth and Mars. Increasing or decreasing mass by 10,000 times changes the speed by 10 times. A 100-gram package could sent ten times faster than a 1,000 kilogram package using the same size laser array and power system. You could send a 1,000 kilogram mission to Mars in 30 days or rapidly deliver an urgent package of 100 grams to Mars in about 3 days.

This system for urgent delivery of tiny packages with 1G acceleration and deceleration would be feasible in the 10–20 year time frame.

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There’s even talk in some quarters that solar could one day fulfil the unrealised promise of nuclear power to generate electricity so abundant that it would be “too cheap to meter”.

So how cheap can solar get? And will you — the energy consumer — still have a power bill?

This future of cheap power is already here — at least sometimes.

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Abstract: Here we show that precise Gaia EDR3 proper motions have provided robust estimates of 3D velocities, angular momentum and total energy for 40 Milky Way dwarfs. The results are statistically robust and are independent of the Milky Way mass profile. Dwarfs do not behave like long-lived satellites of the Milky Way because of their excessively large velocities, angular momenta, and total energies. Comparing them to other MW halo population, we find that many are at first passage, $\le$2 Gyr ago, i.e., more recently than the passage of Sagittarius, $\sim$4–5 Gyr ago. We suggest that this is in agreement with the stellar populations of all dwarfs, for which we find that a small fraction of young stars cannot be excluded. We also find that dwarf radial velocities contribute too little to their kinetic energy when compared to satellite systems with motions only regulated by gravity, and some other mechanism must be at work such as ram pressure. The latter may have preferentially reduced radial velocities when dwarf progenitors entered the halo until they lost their gas. It could also explain why most dwarfs lie near their pericenter. We also discover a novel large scale structure perpendicular to the Milky Way disk, which is made by 20% of dwarfs orbiting or counter orbiting with the Sagittarius dwarf.

From: Francois Hammer [view email].

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“The Earth was very water-rich compared to other rocky planets in the Solar System, with oceans covering more than 70% of its surface, and scientists had long puzzled over the exact source of it all,” said Professor Phil Bland, director of the Space Science and Technology Centre at Curtin University.

“An existing theory is that water was carried to Earth in the final stages of its formation on C-type asteroids, however previous testing of the isotopic ‘fingerprint’ of these asteroids found they, on average, didn’t match with the water found on Earth meaning there was at least one other unaccounted for source.”

“Our research suggests the solar wind created water on the surface of tiny dust grains and this isotopically lighter water likely provided the remainder of the Earth’s water.”

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First theorized in 1973 by physicist Philip W. Anderson, quantum spin liquids are exotic phases of matter with topological order. They feature long-range quantum entanglement that can potentially be exploited to realize robust quantum computation. But the problem about this exotic state of matter has been its very existence: no one had ever seen it — at least, that had been the case for almost five decades.

“Instead, it’s all about magnets that never freeze and the way electrons in them spin.”

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No such fully realised metaverse yet exists but that has not stopped US tech companies from falling over themselves in recent months to announce their own forays into the space. The flurry of interest has shown few signs of abating and Asia is not immune to the trend, as around the world investors and companies scramble to latch onto what many see as the next big thing.

Investors and companies are scrambling to carve out a piece of an internet revolution that promises to forever change how people interact online – but some question whether Big Tech should be allowed to dominate its development.

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