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France’s Jean Zay supercomputer, one of the most powerful computers in the world and part of the Top500, is now the first HPC to have a photonic coprocessor meaning it transmits and processes information using light. The development represents a first for the industry.

The breakthrough was made during a pilot program that saw LightOn collaborate with GENCI and IDRIS. Igor Carron, LightOn’s CEO and co-founder said in a press release: “This pilot program integrating a new computing technology within one of the world’s Supercomputers would not have been possible without the particular commitment of visionary agencies such as GENCI and IDRIS/CNRS. Together with the emergence of Quantum Computing, this world premiere strengthens our view that the next step after exascale supercomputing will be about hybrid computing.”

The technology will now be offered to select users of the Jean Zay research community over the next few months who will use the device to undertake research on machine learning foundations, differential privacy, satellite imaging analysis, and natural language processing (NLP) tasks. LightOn’s technology has already been successfully used by a community of researchers since 2018.

Just two weeks after launching from Vandenberg Space Force Base in California, NASA

Established in 1958, the National Aeronautics and Space Administration (NASA) is an independent agency of the United States Federal Government that succeeded the National Advisory Committee for Aeronautics (NACA). It is responsible for the civilian space program, as well as aeronautics and aerospace research. It’s vision is “To discover and expand knowledge for the benefit of humanity.”

A documentary and journey into the future exploring the possibilities and predictions of artificial intelligence. This timelapse of the future explores what is coming, from robots that are too fast for humans to see, to A.I. bots from Microsoft (bringing back loved ones to life) and Google’s laMDA (replacing the need for online searches).

Elon Musk’s Neuralink goes from a medical and healthcare device, to helping people become superhuman – with intelligence amplification, and add-ons that connect to the brain chip.

Artificial general intelligence begins to design an A.I. more powerful than itself. People begin to question if humanity has reached the technological singularity. Artificial Super Intelligence emerges from the AGI.

And further into the deep future. Human consciousness becomes digitized and uploaded into a metaverse simulation. It is merged with A.I. creating hybrid consciousness – which spreads across the cosmos. Matrioshka brains and Dyson Spheres host humanity’s consciousness in a cosmic simulation network.

It was a big year. Fermilab discovered possible evidence of new physics with the muon G-2 experiment. Physicists created a time crystal, a new phase of matter that appears to violate one of nature’s most cherished laws. And we got a glimpse of an enormous pair of bubbles towering over the Milky Way. Read the articles in full at Quanta: https://www.quantamagazine.org/the-year-in-physics-20211222/

Quanta Magazine is an editorially independent publication supported by the Simons Foundation.

Over-the-counter antioxidants 🤔

Mitochondria are pivotal for bioenergetics, as well as in cellular response to viral infections. Nevertheless, their role in COVID-19 was largely overlooked. Here, we analyzed available bulk RNA-seq datasets from COVID-19 patients and corresponding healthy controls (three blood datasets, N = 48 healthy, 119 patients; two respiratory tract datasets, N = 157 healthy, 524 patients). We found significantly reduced mtDNA gene expression in blood, but not in respiratory tract samples from patients. Next, analysis of eight single-cells RNA-seq datasets from peripheral blood mononuclear cells, nasopharyngeal samples, and Bronchoalveolar lavage fluid (N = 1,192,243 cells), revealed significantly reduced mtDNA gene expression especially in immune system cells from patients. This is associated with elevated expression of nuclear DNA-encoded OXPHOS subunits, suggesting compromised mitochondrial-nuclear co-regulation. This, together with elevated expression of ROS-response genes and glycolysis enzymes in patients, suggest rewiring toward glycolysis, thus generating beneficial conditions for SARS-CoV-2 replication. Our findings underline the centrality of mitochondrial dysfunction in COVID-19.