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Mar 19, 2021

New research provides evidence that a single dose of psilocybin can boost brain connections

Posted by in category: neuroscience

Scientists in Denmark believe the psychedelic substance psilocybin might produce rapid and lasting antidepressant effects in part because it enhances neuroplasticity in the brain. Their new research, published in the International Journal of Molecular Sciences, has found evidence that psilocybin increases the number of neuronal connections in the prefrontal cortex and hippocampus of pig brains.

Psilocybin — the active component in so-called “magic” mushrooms — has been shown to have profound and long-lasting effects on personality and mood. But the mechanisms behind these effects remain unclear. Researchers at Copenhagen University were interested in whether changes in neuroplasticity in brain regions associated with emotional processing could help explain psilocybin’s antidepressant effects.

“Both post-mortem human brain and in vivo studies in depressed individuals have shown a loss of synapses through the down-regulation of synaptic proteins and genes,” the authors of the study wrote. “Hence, upregulation of presynaptic proteins and an increase in synaptic density may be associated with the potential antidepressive effects of psychedelics.”

Mar 19, 2021

Study shows stronger brain activity after writing on paper than on tablet or smartphone

Posted by in categories: mobile phones, neuroscience

A study of Japanese university students and recent graduates has revealed that writing on physical paper can lead to more brain activity when remembering the information an hour later. Researchers say that the complex, spatial and tactile information associated with writing by hand on physical paper is likely what leads to improved memory.

“Actually, paper is more advanced and useful compared to electronic documents because paper contains more one-of-a-kind information for stronger memory recall,” said Professor Kuniyoshi L. Sakai, a neuroscientist at the University of Tokyo and corresponding author of the research recently published in Frontiers in Behavioral Neuroscience. The research was completed with collaborators from the NTT Data Institute of Management Consulting.

Mar 19, 2021

Scientists create model embryos, raising ethical questions

Posted by in category: innovation

Australian researchers have created “model” human embryos from the skin cells of an adult’s arm, in a world-first scientific breakthrough that raises significant ethical questions.

The model embryos, created in a laboratory by researchers at Melbourne’s Monash University, do not use egg or sperm, but ordinary cells that are reprogrammed to replicate the first few days of human life.

When placed in a dish, the model embryos attach – much as embryos would in the uterus – and begin developing.

Mar 19, 2021

Civil liability for damages related to germline and embryo editing against the legal admissibility of gene editing

Posted by in categories: bioengineering, biotech/medical, genetics, law

The development of gene therapy, in particular gene editing using the CRISPR-Cas9 method, has prompted a lively discussion around the world about how deeply you can interfere with the human genome. The creators of this method have turned to the world community, including lawyers, to undertake a public discussion of the implications that it can create (The National Academies of Sciences Engineering Medicine, 2015). The most important problem to be resolved in the future, in my opinion, will be the issue of establishing very clear legal principles of liability for damages resulting from the editing of genes in human embryos and reproductive cells. However, before this happens, it is necessary to show the possible legal problems that may arise and that will certainly appear in future legislative work in the world. Questions must be asked to which world legal experts will need to seek answers. The goal of this paper is to show the possible legal problems and ask questions related to the liability for damages resulting from the editing of genes in human embryos and reproductive cells that will be answered in the future.

Private law considerations will be based on Polish law, although it should be pointed out that the conclusions derived from them appear to be of universal nature for different legal systems. Despite the fact that legal considerations will refer to the regulation of Polish law, the subject of the analysis will also be the differences in the legal qualification of reproductive cells and embryos in other European legislations. It seems that nowhere in the world are there special regulations regarding the liability for damage related to the genetic editing of reproductive cells or embryos. Therefore, there is a need to present new challenges for classic private law institutions, such as legal abilities, torts, or liability for damages. Due to the lack of uniform European regulations and different conflicts of rights the subject of analysis will not be wrongful life and wrongful birth actions, but only claims of prenatal damage to a child.

The first major legal problem facing the international community is, of course, the question of the legal acceptability of the editing of genes of human reproductive cells and embryos (van Dijke et al., 2018). In this regard, it should be pointed out that despite the initial demand to ban such editing, over time, increasingly more scientists have pointed to the fact that it is not possible to maintain such a moratorium (Doudna and Sternberg, 2017). Jiankui’s presentation at the Second International Summit on Human Genome Editing on November 272018, showed that the introduction of a moratorium on genetic modifications of embryos in Europe, the condemnation of such research by a group of 120 of the greatest geneticists, even the Chinese regulations (Zhang and Lie, 2018) will not limit its conduct (Cyranoski and Ledford, 2018). Globalization of the medical market means that if any procedures are allowed on other continents, they will also become available to Europeans (Lunshof, 2016).

Mar 19, 2021

Why Does SpaceX’s Camera Cut Out During Landings?

Posted by in categories: electronics, space travel

We all love watching SpaceX landing the Falcon 9, so why is it so difficult to get footage of it?

Mar 19, 2021

‘The Code Breaker’ tells the story of CRISPR pioneer Jennifer Doudna

Posted by in categories: bioengineering, biotech/medical, ethics

In his latest book, Walter Isaacson chronicles the discovery of CRISPR and delves into the ethics of gene editing.

Mar 19, 2021

Glowing ‘dawn storm’ auroras that blaze in Jupiter’s morning skies are born in darkness

Posted by in category: space travel

New images of Jupiter’s polar auroras, captured by the Juno spacecraft, revealed the full cycle of intense and unusual polar light displays.

Mar 19, 2021

The Pastry A.I. That Learned to Fight Cancer

Posted by in categories: biotech/medical, robotics/AI

In Japan, a system designed to distinguish croissants from bear claws has turned out to be capable of a whole lot more.

Mar 19, 2021

Astronaut Bruce McCandless II floating untethered away from the safety of the space shuttle

Posted by in category: space travel

His Manned Maneuvering Unit all that keeps him from drifting away and becoming “lost in space”.

The first person in history to do this.

Mar 19, 2021

The origin of SARS-CoV-2 furin cleavage site remains a mystery

Posted by in categories: biotech/medical, economics, genetics

“The furin cleavage site consists of four amino acids PRRA, which are encoded by 12 inserted nucleotides in the S gene. A characteristic feature of this site is an arginine doublet. This insertion could have occurred by random insertion mutation, recombination or by laboratory insertion. The researchers say the possibility of random insertion is too low to explain the origin of this motif. Surprisingly, the CGGCGG codons encoding the two arginines of the doublet in SARS-CoV-2 are not found in any of the furin sites in other viral proteins expressed by a wide range of viruses. Even within the SARS-CoV-2, where arginine is encoded by six codons, only a minority of arginine residues are encoded by the CGG codon. Again, only two of the 42 arginines in the SARS-CoV-2 spike are encoded by this codon — and these are in the PRRA motif. For recombination to occur, there must be a donor, from another furin site and probably from another virus. In the absence of a known virus containing this arginine doublet encoded by the CGGCGG codons, the researchers discount the recombination theory as the mechanism underlying the emergence of PRRA in SARS-CoV-2.”


The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has largely defied attempts to contain its spread by non-pharmaceutical interventions (NPIs). With the massive loss of life and economic damage, the only way out, in the absence of specific antiviral therapeutics, has been the development of vaccines to achieve population immunity.

A new study on the Preprints server discusses the origin of the furin cleavage site on the SARS-CoV-2 spike protein, which is responsible for the virus’s relatively high infectivity compared to relatives in the betacoronavirus subgenus.

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