Lifeboat Foundation

This is a truly enlightening 5 min. excerpt by Liz Parrish on gene therapy and its suitability to achieve radical life extension. Among other important aspects, Liz tells us about how regulatory constrains are delaying progress in this important vehicle to treat incurable diseases and aging itself. I added subtitles in Spanish. Don’t miss it!!! In the description of the video is the link to the entire interview.

Este es un extracto muy esclarecedor por parte de Liz Parrish sobre la terapia génica y su idoneidad para lograr una prolongación radical de la vida. Entre otros aspectos importantes, Liz nos cuenta cómo las restricciones regulatorias están retrasando el progreso de este importante vehículo, para tratar enfermedades incurables y el envejecimiento en sí mismo. Le he agregado subtítulos en español. No te lo pierdas!!! En la descripción del video está el enlace a toda la entrevista.

Continue reading “Liz Parrish considerations on gene therapy (excerpts from an interview) (con S/T en Español)” »

Past neuroscience studies have consistently showed that sleep plays an important role in memory consolidation. For instance, some neuroimaging research showed that the brain regions that are activated while humans are encoding waking experiences can later be reactivated during sleep, particularly during non-rapid eye movement (NREM) sleep.

Interestingly, the same brain regions are also associated with increased local slow-wave activity (SWA). Interestingly, the activation of these brain regions and SWA are known to be associated with two mechanisms related to memory optimization, namely neural replay and synaptic homeostasis. These mechanisms are typically associated with improvements in behavior over time.

Researchers at University of Geneva in Switzerland have recently carried out a study aimed at investigating the ways in which the brain selects memories that will be reprocessed during sleep. Their findings, presented in a paper published in Nature Communications, suggest that the brain tends to prioritize the consolidation of memories or life experiences with high motivational relevance, namely those associated with rewards.

There’s no need to don uncomfortable smartwatches or chest straps to monitor your heart if your comfy shirt can do a better job.

That’s the idea behind “smart clothing” developed by a Rice University lab, which employed its conductive nanotube thread to weave functionality into regular apparel.

Continue reading “Flexible carbon nanotube fibers woven into clothing gather accurate EKG, heart rate” »

Wide Area Networks (WANs), the global backbones and workhorses of today’s internet that connect billions of computers over continents and oceans, are the foundation of modern online services. As COVID-19 has placed a vital reliance on online services, today’s networks are struggling to deliver high bandwidth and availability imposed by emerging workloads related to machine learning, video calls, and health care.

To connect WANs over hundreds of miles, fiber optic cables that transmit data using light are threaded throughout our neighborhoods, made of incredibly thin strands of glass or plastic known as optical fibers. While they’re extremely fast, they’re not always reliable: They can easily break from weather, thunderstorms, accidents, and even animals. These tears can cause severe and expensive damage, resulting in 911 service outages, lost connectivity to the internet, and inability to use smartphone apps.

Continue reading “ARROW, a reconfigurable fiber optics network, aims to take on the end of Moore’s law” »

Integrated circuits (ICs) based on organic transistors have many valuable applications, for instance, in the fabrication of paper-like displays or other large-area electronic components. Over the past few decades, electronics engineers worldwide have developed a variety of these transistors.

A promising alternative to these transistors are vertical-channel dual-gate organic thin-film transistors. These transistors have several advantageous properties, such as short channel lengths and tuneable threshold voltages (VTH). Despite these advantages, due to a lack appropriate p-and n-type devices, developing complementary inverter circuits for these transistors has so far proved challenging.

Researchers at Technische Universitat Dresden, Helmholtz-Zentrum Dresden Rossendorf (HZDR) and Northwestern Polytechnical University have recently developed vertical organic permeable dual-base transistors that could be integrated in logic circuits. In a recent paper published in Nature Electronics, they evaluated the potential use of these transistors in complex integrated circuits.

A thought-provoking new article poses some hugely important scientific questions: Could brain cells initiated and grown in a lab become sentient? What would that look like, and how could scientists test for it? And would a sentient, lab-grown brain “organoid” have some kind of rights? Buckle up for a quick and dirty history of the ethics of sentience. We associate the term with computing and artificial intelligence, but the question of who (or what) is or isn’t “sentient” and deserving of rights and moral consideration goes back to the very beginning of the human experience. The debate colors everything from ethical consumption of meat to many episodes of Black Mirror.

Well, we don’t want that… or do we?

Maya Ajmera, President & CEO of Society for Science & the Public and Publisher of Science News, chatted with Ray Kurzweil, an alumnus of the Science Talent Search and a renowned inventor and futurist. Kurzweil also has written five best-selling books, is Cofounder and Chancellor of Singularity University and is a Director of Engineering at Google. We are thrilled to share an edited summary of their conversation.

You are an alum of the1965Science Talent Search. How did the competition impact your life, and are there any particular moments that still stand out for you?

The Westinghouse Science Talent Search was the first time I was recognized nationally. President Johnson had just been elected and we met him at the White House. He told us his goal was that our generation would never see the horrors of war.

In 2,001 Celera Genomics and the International Human Genome Sequencing Consortium published their initial drafts of the human genome, which revolutionized the field of genomics. While these drafts and the updates that followed effectively covered the euchromatic fraction of the genome, the heterochromatin and many other complex regions were left unfinished or erroneous. Addressing this remaining 8% of the genome, the Telomere-to-Telomere (T2T) Consortium has finished the first truly complete 3.055 billion base pair (bp) sequence of a human genome, representing the largest improvement to the human reference genome since its initial release. The new T2T-CHM13 reference includes gapless assemblies for all 22 autosomes plus Chromosome X, corrects numerous errors, and introduces nearly 200 million bp of novel sequence containing 2,226 paralogous gene copies, 115 of which are predicted to be protein coding. The newly completed regions include all centromeric satellite arrays and the short arms of all five acrocentric chromosomes, unlocking these complex regions of the genome to variational and functional studies for the first time.

The latest major update to the human reference genome was released by the Genome Reference Consortium (GRC) in2013and most recently patched in2019(GRCh38.p13). This assembly traces its origin to the publicly funded Human Genome Project and has been continually improved over the past two decades. Unlike the competing Celera assembly , and most modern genome projects that are also based on shotgun sequence assembly , the GRC human reference assembly is primarily based on Sanger sequencing data derived from bacterial artificial chromosome (BAC) clones that were ordered and oriented along the genome via radiation hybrid, genetic linkage, and fingerprint maps. This laborious approach resulted in what remains one of the most continuous and accurate reference genomes today. However, reliance on these technologies limited the assembly to only the euchromatic regions of the genome that could be reliably cloned into BACs, mapped, and assembled.

Technion scientists have created a wearable motion sensor capable of identifying movements such as bending and twisting. This smart ‘e-skin’ was produced using a highly stretchable electronic material, which essentially forms an electronic skin capable of recognizing the range of movement human joints normally make, with up to half a degree precision.

This breakthrough is the result of collaborative work between researchers from different fields in the Laboratory for Nanomaterial-Based Devices, headed by Professor Hossam Haick from the Technion Wolfson Faculty of Chemical Engineering. It was recently published in Advanced Materials and was featured on the journal’s cover.

This wearable motion sensor, which senses bending and twisting, can be applied in healthcare and manufacturing.