Lifeboat Foundation

In rainbow trout, classification of ionocytes based on the expressed transporters is still in progress. The Nhe3-positive ionocytes expressing basolateral Nka and Nkcc1 and apical Nhe3b have been found in both freshwater-and seawater-acclimated rainbow trout. Colocalization of an Rh glycoprotein (Rhcg1, ammonium transporter) and Nhe3b at the apical membrane was also observed, suggesting ammonia-dependent Na⁺ uptake by Nhe3-positive ionocytes (Hiroi and McCormick 2012). The Nhe3-negative ionocytes, which also lack Nkcc1, are observed mainly in freshwater (Katoh et al. 2008; Hiroi and McCormick 2012). Ncc2, the apical Cl⁻ pathway in tilapia type-II ionocytes, is thought to be absent in the gill of salmonids (Hiroi and McCormick 2012). The Nhe3-positive ionocytes showed basolateral Nka and Nkcc1 both in freshwater and seawater, suggesting that Nhe3-positive ionocytes are analogous to tilapia types-III and-IV and could be equipped with apical Cftr in seawater (Hiroi and McCormick 2012; Takei et al. 2014). However, localization of Cftr proteins by immunohistochemistry has not been successful in salmonids even with homologous antibodies (Takei et al. 2014). The mRNA of slc26a6 has been reported to be highly expressed in the gills of freshwater-acclimated rainbow trout (Boyle et al. 2015; Leguen et al. 2015) and it is very likely that this transporter is responsible for the uptake of Cl⁻ in freshwater, but detailed localization of this protein in the gills has not been elucidated. In short, the molecules responsible for the Cl⁻ transport across the apical membrane have not been identified in both freshwater-and seawater-acclimated rainbow trout.

Salmonids possess two cftr genes, cftr1 and cftr2 (Chen et al. 2001), and it has been reported that the expression level of both genes increases in the gill of chum salmon Oncorhynchus keta after the transfer to seawater during the juvenile stage (Wong et al. 2019). Expression of cftr1 in the gills increased also in rainbow trout after seawater transfer (Gerber et al. 2018). On the other hand, dietary salt loading reduced cftr2 expression in the gill of rainbow trout in freshwater (Kolosov and Kelly 2016). At this time, it is not clear which of these two molecules is mainly responsible for hypo-osmoregulatory Cl⁻ secretion in the gills of salmonids.

The objective of the present study is to examine molecules responsible for the active transport of Cl⁻ in gill ionocytes of rainbow trout. To achieve this goal, we conducted tissue distribution analyses on the expression of slc26a6, cftr1, and cftr2 in rainbow trout acclimated to freshwater or seawater. Time-course changes in the expression of these genes were also examined during seawater transfer. We localized these proteins in the gill filaments of rainbow trout acclimated to freshwater or seawater by whole-mount immunohistochemistry.

Further, “the necessity to secure private ideas, plans, and brain data from unpermitted viewing is accorded to Dr. Anita S Jwa by the phrase,” she argues. Besides that, the ethical implications in the fields of informed consent, coercion, and fairness with respect to the common attributes of the BCIs must be critically considered. For example, consider a scenario where a BCI is used to control a prosthetic limb. Without proper privacy measures, “unauthorised access to the BCI could lead to manipulation of the prosthetic limb,” posing risks to the user’s safety and autonomy.

Overcoming these difficulties requires the joint efforts of all the stakeholders, such as researchers, policymakers, and industry leaders. In the same way, we have to critically assess the technical, ethical, and accessibility issues in BCI. We may then be able to capture the potential of these BCIs and ultimately improve human lives.

In this instance, just imagine that we are submerging into the future of BCIs, and to my surprise, it feels like living in a movie where sci-fi is a reality! BCIs are going to be able to do all kinds of really advanced things very soon. People are going to think that they are very cool. We are entering an entirely new realm of brainy gadgets that are becoming smaller, sleeker, and oh-so-wearable. It is now all gear change; the future of BCI is almost as organic as slipping on your dream pair of sunglasses.

One of the most distinctive features of the Transhumanist project is its unflagging confidence that the advances of science and technology will usher humanity into a marvellous post-human future.

No one has expressed this more sharply than Ray Kurzweil, the futurist and engineering director at Google. In his book, The Singularity is Near (2005), Kurzweil famously writes:

… A future period during which the pace of technological change will be so rapid, its impact so deep, that human life will be irreversibly transformed. Although neither utopian or dystopian, this epoch will transform the concepts that we rely on to give meaning to our lives, from our business models to the cycle of human life, including death itself.

M any prominent people in the tech industry have talked about the increasing convergence between humans and machines in coming decades. For example, Elon Musk has reportedly said he wants humans to merge with AI “to achieve a symbiosis with artificial intelligence”

His company Neuralink aims to facilitate this convergence so that humans won’t be “left behind” as technology advances in the future. While people with disabilities would be near-term recipients of these innovations, some believe technologies like this could be used to enhance abilities in everyone.

These aims are inspired by an idea called transhumanism, the belief that we should use science and technology to radically enhance human capabilities and seek to direct our own evolutionary path. Disease, aging and death are all realities transhumanists wish to end, alongside dramatically increasing our cognitive, emotional and physical capacities.

Inside the cult of TESCREALism and the dangerous fantasies of Silicon Valley’s self-appointed demigods, for Document’s Spring/Summer 2024 issue.

As legend has it, Steve Jobs once asked Larry Kenyon, an engineer tasked with developing the Mac computer, to reduce its boot time by 10 seconds. Kenyon said that was impossible. “What if it would save a person’s life?” Jobs asked. Then, he went to a whiteboard and laid out an equation: If 5 million users spent an additional 10 seconds waiting for the computer to start, the total hours wasted would be equivalent to 100 human lifetimes every year. Kenyon shaved 28 seconds off the boot time in a matter of weeks.

Often cited as an example of the late CEO’s “reality distortion field,” this anecdote illustrates the combination of charisma, hyperbole, and marketing with which Jobs convinced his disciples to believe almost anything—elevating himself to divine status and creating “a cult of personality for capitalists,” as Mark Cohen put it in an article about his death for the Australian Broadcasting Corporation. In helping to push the myth of the genius tech founder into the cultural mainstream, Jobs laid the groundwork for future generations of Silicon Valley investors and entrepreneurs who have, amid the global decline of organized religion, become our secular messiahs. They preach from the mounts of Google and Meta, selling the public on digital technology’s saving grace, its righteous ability to reshape the world.

In “The Singularity Is Nearer,” the futurist Ray Kurzweil reckons with a world dominated by artificial intelligence (good) and his own mortality (bad).

Yesterday Daniel Dennett died. He was 82, about the same age as my father when he died a few years ago.

Japan is ignoring EVs and hydrogen, and has a good reason: They are producing the first-ever magnetic levitation engine, and works like that.

Until today, we’ve seen exactly 40 seconds of Boston Dynamics’ new electric Atlas in action. The Hyundai-owned robotics stalwart is very much still in the early stages of commercializing the biped for factory floors. For now, however, it’s doing the thing Boston Dynamics does second best after building robots: showing off in viral video form.

After debuting a short video of the robot doing push-ups during a recent conference presentation, the company has shared the clip with TechCrunch. While this is in no way an indicator of real-world use, it’s a great demonstration of Atlas’ extremely robust and powerful actuators.