Lifeboat Foundation

Using #CellDIVE multiplexed imaging and antibodies from Cell Signaling Technology to uncover cell identity and brain structure in Alzheimer’s disease, demonstrating how spatial biology can lead to advances in therapy development for neuro degeneration.

🖼️: Adult Human Alzheimer’s brain demonstrating a panel of 15 markers.

Uncover cell identity and brain structure in Alzheimer’s disease with Cell DIVE multiplexed imaging, demonstrating how spatial biology can lead to advances in therapy development for neurodegeneration.

Continue reading “The Shape of the Brain: Spatial Biology of Alzheimer’s Disease” »

Dynamic nuclear polarization (DNP) has revolutionized the field of nanoscale nuclear magnetic resonance (NMR), making it possible to study a wider range of materials, biomolecules and complex dynamic processes such as how proteins fold and change shape inside a cell.

The Korea Institute of Energy Research (KIER) has developed a redox-active metal-organic hybrid electrode material (SKIER-5) for Li batteries that remains stable in cold conditions as low as minus 20 degrees Celsius. By addressing the limitations of graphite as an anode material of conventional Li batteries under freezing conditions, SKIER-5 has the potential to be a superior alternative. This novel material can be used in Li batteries for a variety of applications, including electric vehicles, drones, and ultra-small electronic devices, even at low temperatures.

Currently, graphite is the conventional material used for anodes in lithium-ion batteries due to its thermodynamic stability and low cost. However, batteries with graphite anodes have significant drawbacks: their storage capacity sharply decreases at subzero temperatures, and dendrites can form on the anode surface during charging. This can lead to thermal runaway and potential explosions.

A research team led by Dr. Jungjoon Yoo, Dr. Kanghoon Yim, and Dr. Hyunuk Kim at KIER has developed a redox-active conductive metal-organic framework called “SKIER-5.” This framework is assembled from a trianthrene-based organic ligand and nickel ions. SKIER-5 exhibited a discharge capacity five times higher than that of graphite in subzero environments.

Proposed lunar biorepository could store genetic samples without electricity or liquid nitrogen. New research led by scientists at the Smithsonian proposes a plan to safeguard Earth’s imperiled biodiversity by cryogenically preserving biological material on the moon. The moon’s permanently shadowed craters are cold enough for cryogenic preservation without the need for electricity or liquid nitrogen, according to the researchers.

The paper, published today in BioScience and written in collaboration with researchers from the Smithsonian’s National Zoo and Conservation Biology Institute (NZCBI), Smithsonian’s National Museum of Natural History, Smithsonian’s National Air and Space Museum and others, outlines a roadmap to create a lunar biorepository, including ideas for governance, the types of biological material to be stored and a plan for experiments to understand and address challenges such as radiation and microgravity. The study also demonstrates the successful cryopreservation of skin samples from a fish, which are now stored at the National Museum of Natural History.

“Initially, a lunar biorepository would target the most at-risk species on Earth today, but our ultimate goal would be to cryopreserve most species on Earth,” said Mary Hagedorn, a research cryobiologist at NZCBI and lead author of the paper. “We hope that by sharing our vision, our group can find additional partners to expand the conversation, discuss threats and opportunities and conduct the necessary research and testing to make this biorepository a reality.”

Your early morning run could soon help harvest enough electricity to power your wearable devices, thanks to a new nanotechnology developed at the University of Surrey.

Surrey’s Advanced Technology Institute (ATI) has developed highly energy-efficient, flexible nanogenerators, which demonstrate a 140-fold increase in power density when compared to conventional nanogenerators. ATI researchers believe that this development could pave the way for nano-devices that are as efficient as today’s solar cells.

The findings are published in the journal Nano Energy.

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A new approach to quantum computing — working with photons, or \.

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But after five days, Sherif upped the game. He had the two groups compete for food. He limited their resources. It was a fist-swinging, curse-hurling, dust cloud of a mess. When a few punches landed, the adult researchers had to step in, adults with notebooks holding back furious Eagles and violent Rattlers.

Sherif concluded that scarcity was one of the main drivers of all human conflict. War, violence, invasion, and theft were all born of wanting a limited resource. The history of all humanity seems to support the hypothesis: We fight over water, cattle, arable land, ore deposits, oil, precious stones, and so on.

Big Think recently spoke with Oxford University philosopher Nick Bostrom about his new book, Deep Utopia. He’s got good news. Bostrom argues that the future will do away with the need for conflict over scarce resources. To him, the future is plentiful.

What are humanity’s options? Does AI believe in God? In this exclusive Q&A, Nick Bostrom says that the big questions are above his pay grade. But who is in charge, then?