Lifeboat Foundation: Safeguarding Humanity
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Blog – Page 5706

Cardiovascular disease is the leading cause of death worldwide and bears an immense economic burden. Late-stage heart failure often requires total heart transplantation; however, due to donor shortages and lifelong immunosuppression, alternative cardiac regenerative therapies are in high demand. Human pluripotent stem cells (hPSCs), including human embryonic and induced pluripotent stem cells, have emerged as a viable source of human cardiomyocytes for transplantation. Recent developments in several mammalian models of cardiac injury have provided strong evidence of the therapeutic potential of hPSC-derived cardiomyocytes (hPSC-CM), showing their ability to electromechanically integrate with host cardiac tissue and promote functional recovery. In this review, we will discuss recent developments in hPSC-CM differentiation and transplantation strategies for delivery to the heart. We will highlight the mechanisms through which hPSC-CMs contribute to heart repair, review major challenges in successful transplantation of hPSC-CMs, and present solutions that are being explored to address these limitations. We end with a discussion of the clinical use of hPSC-CMs, including hurdles to clinical translation, current clinical trials, and future perspectives on hPSC-CM transplantation.

Cardiovascular disease (CVD) is the leading cause of death worldwide. In the United States alone, CVD is responsible for ~655,000 deaths and contributes to $200 billion in spending each year. CVD can lead to myocardial infarction (MI), also known as a “heart attack,” which results in restricted blood flow and extensive cell death within the infarct zone. Due to the limited regenerative capacity of the human heart, infarcted myocardium is replaced by fibrotic scar tissue with inferior contractile performance. Over time, pathological remodeling leads to ventricular wall thinning, which can progress to heart failure. There is currently no treatment available that can restore lost cardiomyocytes after MI, and conventional therapies typically only manage the symptoms (3, 4).

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Lister says during this talent shortage, companies are going to need to meet the demands of workers, which will likely include a hybrid model.

Her research found that 56% of U.S. workers have a job that can be done at least partially remotely. She says allowing employees to shift their hours, which days they work, and even when they take a break can have a huge impact on retention.

Technology will have an outsized role in how companies implement their hybrid models. Lister says that within five years, employees may be able to meet via hologram instead of through a video call.

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Frogs briefly treated with a five-drug cocktail administered by a wearable bioreactor on the stump were able to regrow a functional, nearly complete limb.

For millions of patients who have lost limbs for reasons ranging from diabetes to trauma, the possibility of regaining function through natural regeneration remains out of reach. Regrowth of legs and arms remains the province of salamanders and superheroes.

But in a study published in the journal Science Advances, scientists at Tufts University and Harvard University’s Wyss Institute have brought us a step closer to the goal of regenerative medicine.

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A newly created nano-architected material exhibits a property that previously was just theoretically possible: it can refract light backward, regardless of the angle at which the light strikes the material.

This property is known as negative refraction and it means that the refractive index—the speed that light can travel through a given material—is negative across a portion of the electromagnetic spectrum at all angles.

Refraction is a common property in materials; think of the way a straw in a glass of water appears shifted to the side, or the way lenses in eyeglasses focus light. But negative refraction does not just involve shifting light a few degrees to one side. Rather, the light is sent in an angle completely opposite from the one at which it entered the material. This has not been observed in nature but, beginning in the 1960s, was theorized to occur in so-called artificially periodic materials—that is, materials constructed to have a specific structural pattern. Only now have fabrication processes have caught up to theory to make a reality.

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New biodegradable straws developed in China are as cheap as plastic, stronger than paper, and made from edible materials — but can they make a difference in the global plastic waste problem?

Plastic everywhere: People produce 330 million tons of plastic every year. Less than 9% of it is recycled, and about 12% is incinerated — the rest ends up polluting our natural environment or languishing in landfills.

About half of this plastic is in disposable products — bags, straws, etc. Because these products are disposable, they’re also cheap, so any equally disposable but more sustainable alternatives are going to need to be cheap, too — and similar quality.

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All-polymer blend solar cells are expected to play an important role in the transition to clean energy technologies because they can be easily produced in large-scale flexible sheets. However, their performance has lagged behind that of more traditional silicon alternatives, as well as other organic solar cells.

All-polymer blend are formed by combining two polymer solutions that solidify into a film on an electrode with in the form of interpenetrating networks, a kind of “phase-separation.” The introduction of solvent additives to the polymer solution has been shown to increase the efficiency of all-polymer blend solar . However, the exact process underlying this improvement has not been fully understood. Now, in a study recently published in ACS Applied Polymer Materials, researchers from Nara Institute of Science and Technology have investigated the performance enhancement mechanism using photoconductive atomic force microscopy (PC-AFM). Their findings are expected to help accelerate the widespread application of polymer-based solar cells.

“The empirical nature of solvent additive-mediated efficiency enhancement has hindered the optimization of all-polymer blend solar cell performance, so there has been an urgent need for a greater understanding of the process,” explains senior author Hiroaki Benten. “To that end, we used PC-AFM to interrogate the nanoarchitecture that underpins the performance enhancement.”

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