Lifeboat Foundation

The genome editing technology CRISPR has emerged as a powerful new tool that can change the way we treat disease. The challenge when altering the genetics of our cells, however, is how to do it safely, effectively, and specifically targeted to the gene, tissue and organ that needs treatment. Scientists at Tufts University and the Broad Institute of Harvard and MIT have developed unique nanoparticles comprised of lipids—fat molecules—that can package and deliver gene editing machinery specifically to the liver. In a study published today in the Proceedings of the National Academy of Sciences, they have shown that they can use the lipid nanoparticles (LNPs) to efficiently deliver the CRISPR machinery into the liver of mice, resulting in specific genome editing and the reduction of blood cholesterol levels by as much as 57%—a reduction that can last for at least several months with just one shot.

The problem of high cholesterol plagues more than 29 million Americans, according to the Centers for Disease Control and Prevention. The condition is complex and can originate from multiple genes as well as nutritional and lifestyle choices, so it is not easy to treat. The Tufts and Broad researchers, however, have modified one gene that could provide a protective effect against elevated cholesterol if it can be shut down by gene editing.

The gene that the researchers focused on codes for the angiopoietin-like 3 enzyme (Angptl3). That enzyme tamps down the activity of other enzymes—lipases—that help break down cholesterol. If researchers can knock out the Angptl3 gene, they can let the lipases do their work and reduce levels of cholesterol in the blood. It turns out that some lucky people have a natural mutation in their Angptl3 gene, leading to consistently low levels of triglycerides and low-density lipoprotein (LDL) cholesterol, commonly called “bad” cholesterol, in their bloodstream without any known clinical downsides.

Turntide’s basic innovation is a software-controlled motor, or switch reluctance motor, that uses precise pulses of energy instead of a constant flow of electricity.

Sometimes the smallest innovations can have the biggest impacts on the world’s efforts to stop global climate change. Arguably, one of the biggest contributors in the fight against climate change to date has been the switch to the humble LED light, which has slashed hundreds of millions of tons of carbon dioxide emissions simply by reducing energy consumption in buildings.

And now firms backed by Robert Downey Jr. and Bill Gates are joining investors like Amazon and iPod inventor Tony Fadell to pour money into a company called Turntide Technologies that believes it has the next great innovation in the world’s efforts to slow global climate change — a better electric motor.

Continue reading “Firms backed by Robert Downey Jr. and Bill Gates have funded an electric motor company that slashes energy consumption” »

New muscles and electronics setup were needed for the crushing pressures.

There’s a lot of research on human life extension… but it’s unclear whether or not it’ll actually work. This is a great roundup of the science already available.

Could human life extension lead to you living for 150 years? We review the latest exciting animal and human research studies to find out.

In autism, male-female imbalance is especially pronounced. Boys are as much as four times more likely to have some form of autism and are also more likely to have severe symptoms.

HAMILTON, ON, March 3, 2021 — Evolutionary forces drive a glaring gender imbalance in the occurrence of many health conditions, including autism, a team of genetics researchers has concluded.

The human genome has evolved to favour the inheritance of very different characteristics in males and females, which in turn makes men more vulnerable to a host of physical and mental health conditions, say the researchers responsible for a new paper published in the Journal of Molecular Evolution.

Continue reading “Evolution drives autism and other conditions to occur much more frequently in boys” »

A new thought experiment indicates that quantum mechanics doesn’t work without strange numbers that turn negative when squared.

Roundworms don’t have eyes or the light-absorbing molecules required to see. Yet, new research shows they can somehow sense color. The study, published in the journal Science, suggests worms use this ability to assess the risk of feasting on potentially dangerous bacteria that secrete blue toxins. The researchers pinpointed two genes that contribute to this spectral sensitivity and are conserved across many organisms, including humans.

“It’s amazing to me that a tiny worm —with neither eyes nor the molecular machinery used by eyes to detect colors—can identify and avoid a toxic bacterium based, in part, on its blue color,” says H. Robert Horvitz, the David H. Koch Professor of Biology at MIT, a member of the McGovern Institute for Brain Research and the Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute Investigator, and the co-senior author of the study. “One of the joys of being a biologist is the opportunity to discover things about nature that no one has ever imagined before.”

The roundworm in question, Caenorhabditis elegans, is only about a millimeter long. Despite their minute stature and simple nervous system, these nematodes display a complex repertoire of behaviors. They can smell, taste, sense touch, react to temperature, and even escape or change their feeding patterns in response to bright, blue light. Although researchers once thought that these worms bury themselves deep in soil, it’s becoming increasingly clear that C. elegans prefers compost heaps above ground that offer some sun exposure. As a result, roundworms may have a need for light-and color-sensing capabilities after all.

Summary: Since 2010, there has been an absolute rise in mortality for adults without a college degree. For those with higher education experience, mortality rates have decreased during the same time period.

Source: Princeton University.

Life expectancy in the United States dropped in 2020 due to COVID-19, but, for American adults without a college degree, the increase in mortality in adulthood occurred even earlier, according to a new study authored by Anne Case and Sir Angus Deaton of Princeton University.

“If you don’t do both, you’re not going to get very far,” he says. He wants to bring “carbon drawdown” technologies into the conversation with genetically modified trees.

Last year, DeLisi organized a workshop with a team of heavy hitters — Sir Richard Roberts (biochemist, Nobel laureate, and staunch advocate for GMOs), Val Giddings (a geneticist at the Information Technology and Innovation Foundation), and researchers from Oak Ridge National Laboratory — to create solutions, like genetically modifying carbon-hungry trees.

And they are close.