Lifeboat Foundation

In the field of optogenetics, scientists investigate the activity of neurons in the brain using light. A team led by Prof. Dr. Ilka Diester and Dr. David Eriksson from the Optophysiology Laboratory at the University of Freiburg has developed a new method to simultaneously conduct laminar recordings, multifiber stimulations, 3D optogenetic stimulation, connectivity inference, and behavioral quantification on brains. Their results are presented in Nature Communications. “Our work paves the way for large-scale photo-recording and controlled interrogation of fast neural communication in any combination of brain areas,” Diester explains. “This can help us unravel the rapid and multilayered dialogs between neurons that maintain brain function.”

The research group, in collaboration with Dr. Patrick Ruther of the Department of Microsystems Engineering (IMTEK) at the University of Freiburg, is developing a new method for the controlled interrogation and recording of neuronal activity in the brain. To do this, the team is taking advantage of thin, cell-sized optical fibers for minimally invasive optogenetic implantation. “We combine side-emitting fibers with silicon probes to achieve high-quality recordings and ultrafast, multichannel optogenetic control.”

They call the system Fused Fiber Light Emission and eXtracellular Recording, or FFLEXR. In addition to optical fibers that can be attached to any silicon probe, the team uses linear depth-resolved stimulation, a lightweight fiber matrix connector, a flexible multifiber ribbon cable, an optical commutator for efficient multichannel stimulation, a general-purpose patch cable, and an algorithm to manage the photovoltaic response.

Deep learning is “a ball of mud accumulating all of AI,” says Amazon VP and distinguished scientist Nikko Ström. Integrating symbolic reasoning and learning eff… See more.

Integrating symbolic reasoning and learning efficiently from interactions with the world are two major remaining challenges, says vice president and distinguished scientist Nikko Ström.

Yesterday, LHCb submitted for publication new results of matter-antimatter oscillations using decays of charm particles, significantly improving the current experimental knowledge!

Read our news: https://lhcb-outreach.web.cern.ch/2022/02/21/high-precision-…ht-mesons/

Today, the LHCb Collaboration submitted for publication a paper that reports the results of the high precision measurement of the charm oscillation (mixing) parameter y_CP – y_CP^Kπ using two body D⁰ meson decays. The result is more precise than the current world average value by a factor of four.

Continue reading “High precision measurement of the charm oscillation parameter yCP — yCPKπ using decays of D0 mesons to two light mesons” »

A new tool can help companies unlock digital transformation—for operations excellence in the next normal and beyond.

Beavers are headed north, and they’re remaking the Alaskan tundra as they go.

Beavers are headed north, and they’re remaking the Alaskan tundra as they go.

Doorbells are among those everyday objects that started out simple but picked up an immense amount of complexity over the years. What began as a mechanism to bang two pieces of metal together evolved into all kinds of wired and wireless electric bells, finally culminating in today’s smart doorbells that beam a live video feed to their owners even if they’re half a world away.

But sometimes, less is more. [Low tech obsession] built a doorbell out of spare components that doesn’t require Internet connectivity or even a power supply. But it’s not a purely mechanical device either: the visitor turns a knob mounted on a stepper motor, generating pulses of alternating current. These pulses are then fed into the voice coil of an old hard drive, causing its arm to vibrate and strike a bell, mounted where the platters used to be.

Continue reading “Minimalistic Doorbell Doesn’t Need An Internet Connection — Or Even A Power Supply” »

Tesla asks for help… SpaceX stacks… Elon Musk pays in Doge. It’s the free edition of Musk Reads #286.

And for our premium members — last week, you learned about Moon Bikes. This week, you will hear from author Jimmy Soni about what Musk’s earliest success reveals about his management style.

Continue reading “Tesla pushes back” »

Russia in 2008 and 2014 used the same playbook currently being enacted in Eastern Ukraine. Can the world reverse the march to war?

Regrowing or replacing bone lost to disease is tricky and often painful. In a new study Australian researchers have found a relatively simple way to induce stem cells to turn into bone cells quickly and efficiently, using high-frequency sound waves.

Stem cells have enormous medical potential in helping to regenerate various tissues in the body, but bone has proven particularly hard to work with. Bone originates from what are known as mesenchymal stem cells (MSCs), which mostly reside in the bone marrow. Collecting these is a painful procedure, then converting them into bone cells is difficult to scale up to useful levels.

But researchers from RMIT have now found a faster and simpler way to induce MSCs to turn into bone cells. Previous studies have suggested that the vibrations from sound waves can induce cell differentiation, but it typically took over a week with mixed results. These experiments have been limited to low frequencies, and it was thought that higher frequencies would have little benefit. So for the new study, the RMIT team investigated these higher frequencies.