Wang, W., Liu, X., Liu, H. et al. p53: from understanding its structure to advances in therapeutic targeting. Sig Transduct Target Ther 11, 121 (2026). https://doi.org/10.1038/s41392-025-02549-5
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EarthSpace 2026
Register now for 2026! A discussion of Earth and space on Earth Day, with Frank White, me, and other great guests!
EarthSpace 2026 brings together leaders, thinkers, and builders to explore one core idea: the future of Earth and the future of space are not separate conversations.
From climate solutions to space infrastructure, from policy to culture, the choices we make today will define how humanity lives on this planet—and beyond it.
This is not a passive webinar. It’s a focused, high-signal conversation with people actively shaping the frontier.
Nociceptive neurons protect cancer cells against oxidative stress
How cancer cells exploit the tumor microenvironment to alleviate oxidative stress remains largely unclear. Zhang et al. find that nociceptive neurons, via secretion of EREG, protect HNSCC against oxidative stress-induced cell death. Targeting nociceptive neurons improves the therapeutic efficacy of chemotherapies, including cisplatin.
The sialic shield of leukemia cells
A coat of sialylated protein protects human leukemia cells from destruction.
Learn more in a new Science Perspective.
Stefania Canè and Vincenzo Bronte Authors Info & Affiliations
Science.
A simple shot shows promise to reverse osteoarthritis within weeks
A research team including scientists and engineers from University of Colorado Boulder, CU Anschutz and Colorado State University has developed a suite of new therapies that prompt aging or damaged joints to repair themselves within weeks, according to animal studies.
The new osteoarthritis treatments include a single, regenerative injection to a joint and a biomaterial repair kit that recruits the body’s own cells to patch holes in damaged cartilage.
To expedite the research, the federal Advanced Research Projects Agency for Health (ARPA-H) announced this week that the multidisciplinary team will advance to the next phase of the project.
What’s happening when we struggle to retrieve words we know?
The struggle is real when word retrieval goes wrong: see what’s happening in the brain during tip-of-the-tongue moments
The sun is tearing an asteroid to pieces, and Earth is now flying through the fallout
Across Earth, every night, thousands of automated stargazers are waiting to take pictures of shooting stars. I am one of the scientists who study these meteors.
Most movies and news alerts focus on large asteroids that could destroy Earth. And your phone notifies you every few months that an object nine washing machines wide is going to just narrowly skim past. However, the small dust and rubble that enter our atmosphere daily tell an equally interesting story.
My planetary science colleagues and I use camera observations of the night sky to better understand dust, car-sized asteroids and debris from comets in our solar system.