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Scientists at the Institute of Cancer Research in London have developed a new light-activated “photoimmunotherapy” that could help treat brain cancer. The key is a compound that glows under light to guide surgeons to the tumor, while near-infrared light activates a cancer-killing mechanism.

The new study builds on a common technique called Fluorescence Guided Surgery (FGS), which involves introducing a fluorescent agent to the body which glows under exposure to light. This is paired with a synthetic molecule that binds to a specific protein, such as those expressed by cancer cells. The end result is tumors that glow under certain lighting conditions or imaging, guiding surgeons to remove the affected cells more precisely.

For the new study, the researchers gave the technique an extra ability – killing the cancer as well. They added a new molecule that binds to a protein called EGFR, which is often mutated in cases of the brain cancer glioblastoma. After the fluorescence has helped surgeons remove the bulk of the tumor, they can shine near-infrared light on the site, which switches the compound into a tumor-killing mode by releasing reactive oxygen species. The idea is to kill off any remaining cells that could – and often do – stage an aggressive comeback after surgery.

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University of ChicagoFounded in 1,890, the University of Chicago (UChicago, U of C, or Chicago) is a private research university in Chicago, Illinois. Located on a 217-acre campus in Chicago’s Hyde Park neighborhood, near Lake Michigan, the school holds top-ten positions in various national and international rankings. UChicago is also well known for its professional schools: Pritzker School of Medicine, Booth School of Business, Law School, School of Social Service Administration, Harris School of Public Policy Studies, Divinity School and the Graham School of Continuing Liberal and Professional Studies, and Pritzker School of Molecular Engineering.

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Echolocation is a skill we usually associate with animals such as bats and whales, but some blind humans also use the echoes of their own sounds to detect obstacles and their outlines. Some use the tapping of a cane or the snapping of their fingers to make the necessary noise, while others use their mouths to make a clicking sound.

Despite how useful this skill can be, very few blind people are currently taught how to do it. Expert echolocators have been trying to spread t… See more.

With enough training, most humans can learn how to echolocate, using their tongue to make clicking sounds and interpreting the echoes that come back, reflected from the surrounding environment.

In as few as 10 weeks, researchers have been able to teach participants how to navigate obstacles and recognize the size and orientation of objects using the rebounding calls of their clicks.

Continue reading “Humans Can Learn to ‘Echolocate’ in Just 10 Weeks, Experiment Shows” | >

A long-running human trial has shown that CRISPR gene editing could prove to be a highly effective way of treating serious conditions.

The trial, which was kicked off in 2019 by an international team of scientists, found that a new gene-editing therapy called exagamglogene autotemcel, or ex-cel for short, was able to essentially “cure” patients with transfusion-dependent beta thalassemia (TDT) or severe sickle cell disease (SCD), two blood disorders that are conventionally treated using blood transfusions.

It’s a promising new use of the technology. Around 100,000 Americans are affected by TDT, while SCD affects an estimated 300 to 3,000. And in a broader sense, the results suggest that tinkering with genetic code could come to be a practical, widespread new area of medicine.

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The violent death throes of a nearby star so thoroughly disrupted its planetary system that the dead star left behind—known as a white dwarf—is sucking in debris from both the system’s inner and outer reaches, UCLA astronomers and colleagues report today.

This is the first case of cosmic cannibalism in which astronomers have observed a white dwarf consuming both rocky-metallic material, likely from a nearby asteroid, and icy material, presumed to be from a body similar to those found in the Kuiper belt at the fringe of our own solar system.

“We have never seen both of these kinds of objects accreting onto a white dwarf at the same time,” said lead researcher Ted Johnson, a physics and astronomy major at UCLA who graduated last week. “By studying these white dwarfs, we hope to gain a better understanding of planetary systems that are still intact.”

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It’s a given that certain bacteria and viruses can cause illness and disease, but the real culprits are the sequences of concern that lie within the genomes of these microbes.

Calling them out is about to get easier.

Years of work by Rice University computer scientists and their colleagues have led to an improved platform for DNA screening and pathogenic sequence characterization, whether naturally occurring or synthetic, before they have the chance to impact public health.

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A team of researchers at the Institute of Biochemistry at Münster University discovered that by using so-called FlashCaps they were able to control the translation of mRNA by means of light. The results have been published in Nature Chemistry.

DNA () is a long chain of molecules composed of many individual components, and it forms the basis of life on Earth. The function of DNA is to store all genetic information. The translation of this into proteins—which an organism needs to function, develop and reproduce—takes place via mRNA (messenger ribonucleic acid). The DNA is transcribed to mRNA, and the mRNA in turn is translated into proteins (protein biosynthesis). In other words, the mRNA functions as an information carrier. Biochemists at the University of Münster have now developed a new biochemical tool that is able to to control the translation of RNA with the aid of light. These so-called FlashCaps enable researchers to control a variety of processes in cells both spatially and temporally and, as a result, to determine basic functions of proteins.

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