Lifeboat Foundation

Here we report a rapid Scalable and Portable Testing (SPOT) system consisting of a rapid, highly sensitive, and accurate assay and a battery-powered portable device for COVID-19 diagnosis. This device consists of 3D printed casing and internal structure with precise temperature control and fluorescence detection, whereas this assay combines RT-LAMP with an Argonaute protein from hyperthermophilic archaeon Pyrococcus furiosus (PfAgo) capable of precise recognition and cleavage of a target DNA at 95 °C as directed by small 5′-phosphorylated single strand DNA (ssDNA) as guide DNA (gDNA)10,11. Due to the multi-turnover activity of PfAgo, its secondary cleavage mechanism can be harnessed for specific, sensitive, and multiplex nucleic acid detection12,13. For COVID-19 samples, although nasopharyngeal swab and nasal swab samples were recommended for detection of SARS-CoV-2, saliva samples are a more attractive alternative due to the ease, safety, and non-invasive nature of its collection14,15, and its relatively high viral load during the first week of infection16. These benefits enable a saliva sample to be an ideal specimen for reliable and rapid self-detection without professional supervision17,18,19. While current CRISPR-based detection systems normally require 50 min for testing, PfAgo can dramatically speed up the detection process by requiring only 3–5 min for cleavage of amplified products, thereby shortening the total turnaround time for testing to less than 30 min. Moreover, successful PfAgo detection requires at least two sequence-specific cleavages, endowing the SPOT system with high specificity and the ability for multiplexing. Finally, to validate the SPOT system, the sensitivity and accuracy of the SPOT system were determined by using 104 clinical saliva samples.

- please note: The SPOT system also may be useful for detecting genetic markers of certain types of cancer in saliva.

There is a clear need for rapid, accurate and scalable Covid-19 diagnostics. Here the authors use PfAgo to detect viral sequences amplified by RT-LAMP in a handheld battery-powered device.

But the hydrogen-based material requires high pressure.

A kidney grown in a genetically altered pig functions normally, scientists reported. The procedure may open the door to a renewable source of desperately needed organs.

A kidney grown in a genetically altered pig functions normally, scientists reported. The procedure may open the door to a renewable source of desperately needed organs.

The iron-based superconductor material, Ba1−xKxFe2As2. Vadim Grinenko, Federico Caglieris/KTH Royal Institute of Technology

Twenty years ago, scientists first predicted electron quadruplets. Now, KTH Professor Egor Babaev, with the aid of international collaborators, has revealed evidence of fermion quadrupling in a series of experimental measurements on the iron-based material, Ba _1−x K_x Fe ₂ As ₂.

This is the first-ever experimental evidence of this quadrupling effect and the mechanism by which this state of matter occurs.

Protein intake is known to be vital for maintaining brain function in older individuals. Now, using a mouse model of Alzheimer’s disease, researchers have shown that the intake of a specific set of amino acids can inhibit the death of brain cells, protect the connections between them, and reduce inflammation, preserving brain function. Their research suggests that this amino acid combination called Amino LP7 can hinder the development of dementia, including Alzheimer’s disease.

The Large Hadron Collider (LHC) sparked worldwide excitement in March as particle physicists reported tantalising evidence for new physics — potentially a new force of nature. Now, our new result, yet to be peer reviewed, from Cern’s gargantuan particle collider seems to be adding further support to the idea.

Our current best theory of particles and forces is known as the standard model, which describes everything we know about the physical stuff that makes up the world around us with unerring accuracy. The standard model is without doubt the most successful scientific theory ever written down and yet at the same time we know it must be incomplete.

Famously, it describes only three of the four fundamental forces – the electromagnetic force and strong and weak forces, leaving out gravity. It has no explanation for the dark matter that astronomy tells us dominates the universe, and cannot explain how matter survived during the big bang. Most physicists are therefore confident that there must be more cosmic ingredients yet to be discovered, and studying a variety of fundamental particles known as beauty quarks is a particularly promising way to get hints of what else might be out there.

NASA has released a new video that imagines future human explorers and space tourists.

Robotic missions have toured much of our Solar System – but so far, the only place beyond Earth where humans have stood is the Moon. That may change in the coming decades, with space agencies vying to achieve the historic milestone of putting the first astronaut on Mars. Towards the end of this century, as the cost of launching into space is reduced to a few cents per kilogram, space tourism may become as cheap as a transatlantic flight today. New forms of space propulsion in the 22nd century and beyond may open up the stars to human settlement.

In this short film, NASA has visualised some of the distant places that lie waiting to be explored. We get a glimpse of people on the Red Planet, standing in a cloud city on Venus, drifting towards the water plumes of Enceladus, and even kayaking on Titan. We are then provided with scientifically accurate depictions of exoplanets that humans may visit in the more distant future.

Most of us control light all the time without even thinking about it, usually in mundane ways: we don a pair of sunglasses and put on sunscreen, and close—or open—our window blinds.

But the control of light can also come in high-tech forms. The screen of the computer, tablet, or phone on which you are reading this is one example. Another is telecommunications, which controls light to create signals that carry data along fiber-optic cables.

Scientists also use high-tech methods to control light in the laboratory, and now, thanks to a new breakthrough that uses a specialized material only three atoms thick, they can control light more precisely than ever before.

Jetson One is an electrical VTOL flying vehicle you can actually buy—well, pre-order—that shows not only that it can be done but that it can be done with style and flair. The catch is battery life—about 20m flight time per charge for a 187lb rider.

A complete vehicle is 92 000 USD and is delivered to you as a partially (50%) assembled kit for home completion. It contains everything you need, from the aluminium space frame to motor controllers, propellers and motors. You will also receive detailed build instructions.

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