Lifeboat Foundation

SARS-CoV-2 remains a global threat to human health particularly as escape mutants emerge. There is an unmet need for effective treatments against COVID-19 for which neutralizing single domain antibodies (nanobodies) have significant potential. Their small size and stability mean that nanobodies are compatible with respiratory administration. We report four nanobodies (C5, H3, C1, F2) engineered as homotrimers with pmolar affinity for the receptor binding domain (RBD) of the SARS-CoV-2 spike protein. Crystal structures show C5 and H3 overlap the ACE2 epitope, whilst C1 and F2 bind to a different epitope. Cryo Electron Microscopy shows C5 binding results in an all down arrangement of the Spike protein. C1, H3 and C5 all neutralize the Victoria strain, and the highly transmissible Alpha (B.1.1.7 first identified in Kent, UK) strain and C1 also neutralizes the Beta (B.1.35, first identified in South Africa). Administration of C5-trimer via the respiratory route showed potent therapeutic efficacy in the Syrian hamster model of COVID-19 and separately, effective prophylaxis. The molecule was similarly potent by intraperitoneal injection.

Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2. Nat. Struct. Mol. Biol. 27 846–854 (2020).

Last year, physicists reported that an experimental dark matter detector picked up a strange signal that could hint at new physics, with several suspects highlighted. Now, Cambridge scientists have proposed an answer that wasn’t considered at the time – the experiment may have picked up the first direct detection of dark energy, the mysterious force that’s accelerating the expansion of the universe.

Although it’s thought to outnumber regular matter five to one, dark matter remains elusive. It doesn’t interact with light and seems to mostly make itself known through gravitational influence on cosmic scales, like stars, galaxies and galaxy clusters. But once in a while, a dark matter particle might bump into a regular matter particle in a way that we could detect, with the right equipment.

XENON1T was one version of that equipment. Running in Italy between 2016 and 2,018 the experiment was essentially a big tank full of liquid xenon, kept deep underground. The idea was that if a dark matter particle zipped through the tank, it would excite the xenon atoms to produce a flash of light and free electrons, which a suite of sensors can detect.

Circa 2020

Like watching a movie in reverse, physicists have just demonstrated a new technique for the time-reversal of a wave of optical light.

Continue reading “Physicists Create Time-Reversed Waves of Optical Light in Head-Spinning First” »

Thu, Sep 30 at 4 PM PDT.

Black holes are cosmic objects so small and dense that nothing, not even light, can escape their gravitational pull. Until recently, no one had ever seen what a black hole actually looked like. Einstein’s theories predict that a distant observer should see a ring of light encircling the black hole, which forms when radiation emitted by infalling hot gas is lensed by the extreme gravity near the event horizon. The Event Horizon Telescope (EHT) is a global array of radio dishes, linked together by a network of atomic clocks to form an Earth-sized virtual telescope that can resolve the nearest supermassive black holes where this ring feature may be measured. On April 10th, 2,019 the EHT project reported success: we imaged a black hole, and saw the predicted strong gravitational lensing that confirms the theory of General Relativity at the boundary of a black hole. This talk will cover how this was accomplished, details of the first results, as well as future directions that will enable real-time black hole movies.

About Dr. Shep Doeleman:

Researchers have rediscovered a century-old cancer treatment, injecting dead bacteria into tumors to help the immune system target and kill the cancerous cells. Preclinical tests and early human trials indicate the treatment is safe and potentially effective.

In the late 19th century a scientist by the name of William Coley suspected an unusual relationship between bacterial infection and cancer remission. Coley began experimenting with different bacterial formulations to treat cancer.

These formulations became known as “Coley’s toxins” and Coley inadvertently, and unknowingly, became a pioneer of cancer immunotherapy. For much of the 20th century Coley’s research was relegated to a footnote in science history. His experiments were somewhat erratic and lacked any standardization, so very few researchers were able to replicate his results.

2021 SG was bigger than the bolide that blew up over Russia in 2013.

Computer simulations hint that a Mars-sized twin of Earth could be lurking somewhere in the solar system’s mysterious ‘third zone’! Let’s find it.

Ummm wtf o.o!

Computer simulations hint that a Mars-sized twin of Earth could be lurking somewhere in the solar system’s mysterious ‘third zone’! Let’s find it.

Continue reading “Evidence Indicates There’s Another Planet the Size of Mars in Our Solar System” »

Tesla has been making participants in the “Full Self-Driving” beta test sign non-disclosure agreements, but CEO Elon Musk said Tuesday “we probably don’t need” them.

The reason? “There’s a lot of videos” being shared of the beta software in action, Musk said on Tuesday during the 2021 Code Conference. “People don’t seem to listen to me” and are “just ignoring it anyway.”

“I don’t know why there’s an NDA,” he said.

Electrons in two-dimensional hexagonal materials have an extra degree of freedom, the valley pseudospin, that can be used to encode and process quantum information. Valley-selective excitations, governed by the circularly polarized light resonant with the material’s bandgap, are the foundation of valleytronics. It is often assumed that achieving valley selective excitation in pristine graphene with all-optical means is not possible due to the inversion symmetry of the system. Here, we demonstrate that both valley-selective excitation and valley-selective high-harmonic generation can be achieved in pristine graphene by using a combination of two counter-rotating circularly polarized fields, the fundamental and its second harmonic. Controlling the relative phase between the two colors allows us to select the valleys where the electron–hole pairs and higher-order harmonics are generated. We also describe an all-optical method for measuring valley polarization in graphene with a weak probe pulse. This work offers a robust recipe to write and read valley-selective electron excitations in materials with zero bandgap and zero Berry curvature.