Lifeboat Foundation

The EV could become the fastest accelerating production car of all time vehicle when it debuts.

Summary: Study reveals how somatostatin and copper affect amyloid beta in Alzheimer’s disease pathology.

Source: KAIST

With nearly 50 million dementia patients worldwide, and Alzheimers’s disease is the most common neurodegenerative disease. Its main symptom is the impairment of general cognitive abilities, including the ability to speak or to remember.

Continue reading “How a Neurotransmitter May Be the Key in Controlling Alzheimer’s Toxicity​” »

“Most young scientists are eager to know how to become successful, the key qualities of a successful scientist, and the secret formula for success” — [cut to…

For scientists searching for the brain’s ‘control room, an area called the claustrum has emerged as a compelling candidate. This little-studied deep brain structure is thought to be the place where multiple senses are brought together, attention is controlled, and consciousness arises. Observations in mice now support the role of the claustrum as a hub for coordinating activity across the brain. New research from the RIKEN Center for Brain Science (CBS) shows that slow-wave brain activity, a characteristic of sleep and resting states, is controlled by the claustrum. The synchronization of silent and active states across large parts of the brain by these slow waves could contribute to consciousness.

A serendipitous discovery actually led Yoshihiro Yoshihara, team leader at CBS, to investigate the claustrum. His lab normally studies the sense of smell and the detection of pheromones, but they chanced upon a genetically engineered mouse strain with a specific population of brain cells that was present only in the claustrum. These neurons could be turned on using optogenetic technology or selectively silenced through genetic manipulation, thus enabling the study of what turned out to be a vast, claustrum-controlled network. The study by Yoshihara and colleagues was published in Nature Neuroscience on May 11.

They started out by mapping the claustrum’s inputs and outputs and found that many higher-order brain areas send connections to the claustrum, such as those involved in sensation and motor control. Outgoing connections from the claustrum were broadly distributed across the brain, reaching numerous brain areas such as prefrontal, orbital, cingulate, motor, insular, and entorhinal cortices. “The claustrum is at the center of a widespread brain network, covering areas that are involved in cognitive processing,” says co-first author Kimiya Narikiyo. “It essentially reaches all higher brain areas and all types of neurons, making it a potential orchestrator of brain-wide activity.”

Millions of people are administered general anesthesia each year in the United States alone, but it’s not always easy to tell whether they are actually unconscious.

A small proportion of those patients regain some awareness during medical procedures, but a new study of the brain activity that represents consciousness could prevent that potential trauma. It may also help both people in comas and scientists struggling to define which parts of the brain can claim to be key to the conscious mind.

“What has been shown for 100 years in an unconscious state like sleep are these slow waves of electrical activity in the brain,” says Yuri Saalmann, a University of Wisconsin-Madison psychology and neuroscience professor. “But those may not be the right signals to tap into. Under a number of conditions—with different anesthetic drugs, in people that are suffering from a coma or with brain damage or other clinical situations—there can be high-frequency activity as well.”

For now, the acrylic table is under construction and open only to the stuffed mouse, originally a cat toy, used to help set up the cameras. The toy squeaks when Kennedy presses it. “Usually, you do a surgery to remove the squeaker” before using them to set up experiments, says Kennedy, assistant professor of neuroscience at Northwestern University in Chicago, Illinois.

The playful squeak is a startling sound in a lab that is otherwise defined by the quiet of computational modeling. Among her projects, Kennedy is expanding her work with an artificial-intelligence-driven tool called the Mouse Action Recognition System (MARS) that can automatically classify mouse social behaviors. She also uses her modeling work to study how different brain areas and cell types interact with one another, and to connect neural activity with behaviors to learn how the brain integrates sensory information. In her office on the fifth floor of Northwestern’s Ward Building in downtown Chicago, most of this work happens on computers with data, code and graphs. Quiet also prevails in a room down the hall, where Kennedy’s small group of postdoctoral researchers and technicians sit at workstations in a lab that she launched less than a year and a half ago.

Kennedy’s ability to talk about abstract concepts, with a little stuffed animal as a prop, sets her apart, her colleagues say. She is a rare theoretical neuroscientist who can translate her mathematical work into real-world experiments. “That is her gift,” says Larry Abbott, a theoretical neuroscientist at Columbia University who was Kennedy’s graduate school advisor. “She’s good at the technical stuff, but if you can’t make that reach across to the data and the experiments, a person is not going to be that effective. She’s really just great at that — finding the right mathematics to apply to the particular problem that she’s looking at.”

Billions of years in the future, The Time Traveler stands before a black ocean, under a bloated sun. The shore is scaled with lichen and flecked with snow. The crab things and giant insects that menaced him on his visit millions of years in its past are gone. Apart from the lapping of dark waves, everything is utterly still.

He thinks he sees something shifting in the waves nearby but dismisses it as an illusion; assuming it to be a rock. Still a churning weakness and fear deters him from leaving the saddle of the time machine. Perhaps this anxiety is just prompted by the ultimate desolation of this world.

Studying the unknown constellations, he feels a chill wind. The old sun is being eclipsed by the moon, or some other massive body – for it is possible that the Earth has shifted into a new orbit around its star.

By Natasha Vita-More.

Has the technological singularity in 2019 changed since the late 1990s?

As a theoretical concept it has become more recognized. As a potential threat, it is significantly written about and talked about. Because the field of narrow AI is growing and machine learning has found a place in academics and entrepreneurs are investing in the growth of AI, tech leaders have come to the table and voiced their concerns, especially Bill Gates, Elon Musk, and the late Stephen Hawking. The concept of existential risk has taken a central position within the discussions about AI and machine ethicists are prepping their arguments toward a consensus that near-future robots will force us to rethink the exponential advances in the fields of robotics and computer science. Here it is crucial for those leaders in philosophy and ethics to address the concept of what an ethical machine means and the true goal of machine ethics.

Quantum entanglement is one of the most fundamental and intriguing phenomena in nature. Recent research on entanglement has proven to be a valuable resource for quantum communication and information processing. Now, scientists from Japan have discovered a stable quantum entangled state of two protons on a silicon surface, opening doors to an organic union of classical and quantum computing platforms and potentially strengthening the future of quantum technology.

One of the most interesting phenomena in quantum mechanics is “quantum entanglement.” This phenomenon describes how certain particles are inextricably linked, such that their states can only be described with reference to each other. This particle interaction also forms the basis of quantum computing. And this is why, in recent years, physicists have looked for techniques to generate entanglement. However, these techniques confront a number of engineering hurdles, including limitations in creating large number of “qubits” (quantum bits, the basic unit of quantum information), the need to maintain extremely low temperatures (1 K), and the use of ultrapure materials. Surfaces or interfaces are crucial in the formation of quantum entanglement. Unfortunately, electrons confined to surfaces are prone to “decoherence,” a condition in which there is no defined phase relationship between the two distinct states.