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Engineered “natural killer” cells could help fight cancer

The researchers tested these CAR-NK cells in mice with a human-like immune system. These mice were also injected with lymphoma cells.

Mice that received CAR-NK cells with the new construct maintained the NK cell population for at least three weeks, and the NK cells were able to nearly eliminate cancer in those mice. In mice that received either NK cells with no genetic modifications or NK cells with only the CAR gene, the host immune cells attacked the donor NK cells. In these mice, the NK cells died out within two weeks, and the cancer spread unchecked.

The researchers also found that these engineered CAR-NK cells were much less likely to induce cytokine release syndrome — a common side effect of immunotherapy treatments, which can cause life-threatening complications.

Galvanizing blood vessel cells to expand for organ transplantation

Scientists have discovered a method to induce human endothelial cells from a small biopsy sample to multiply in the laboratory, producing more than enough cells to replace damaged blood vessels or nourish organs for transplantation, according to a preclinical study by Weill Cornell Medicine investigators.

Endothelial cells form the inner lining of blood vessels and regulate blood flow, inflammation and healing. Traditional approaches for growing these cells in the lab have yielded only limited numbers before they lose their ability to function. The new method involves treating adult endothelial cells with a small molecule that triggers the hibernating cells to wake up and divide hundreds of times without signs of aging, mutation or loss of function.

The findings, published Oct. 14 in Nature Cardiovascular Research, may provide a reliable way to generate an enormous number of a patient’s own endothelial cells, enabling vascular grafts for , diabetes treatments and and strategies to target abnormal tumor blood vessels.

What is the weak nuclear force and why is it important?

So the weak force doesn’t play by the normal rules — and, in fact, it breaks one of the biggest rules of all.

All of the other forces of nature obey something called parity symmetry. If you run a physics experiment and compare it with the same experiment in the mirror, the results should come out the same.

Mathematical model could help boost drug efficacy by getting dosing in rhythm with circadian clocks

Researchers at the University of Michigan have developed a mathematical model that reveals how our circadian rhythms can have dramatic impacts on how our bodies interact with medicines.

This could help doctors prescribe medicines to have the best intended effect by syncing the dosing up with the natural clocks of their patients.

“These findings provide a mechanistic basis for chronotherapeutics—optimizing drug efficacy by considering circadian timing,” said the new study’s author Tianyong Yao, an undergraduate researcher in the U-M Department of Mathematics. “This could improve treatment for conditions such as ADHD, depression and fatigue.”

Can we hear gravitational-wave ‘beats’ in the rhythm of pulsars?

Pulsars suggest that ultra–low-frequency gravitational waves are rippling through the cosmos. The signal seen by international pulsar timing array collaborations in 2023 could come from a stochastic gravitational-wave background—the sum of many distant sources—or from a single nearby binary of supermassive black holes.

To tell these apart, Hideki Asada, and Professor at Hirosaki University, and Shun Yamamoto, researcher at the Graduate School of Science and Technology, Hirosaki University, propose a method that exploits beat phenomena between gravitational waves at nearly the same frequency, searching for their imprint in the tiny shifts of pulsars’ radio-pulse arrival times.

Their work has been published in the Journal of Cosmology and Astroparticle Physics.

World’s largest rays may be diving to extreme depths to build mental maps of vast oceans

Many marine species are no strangers to the depths of the oceans. Some animals, like certain sharks, tuna, or turtles, routinely perform extreme dives, whereas for other species, such behavior has been observed less frequently.

Now, an international team of researchers working in Peru, Indonesia, and New Zealand tagged oceanic manta rays—the largest species of ray—to learn more about the deep-diving behavior of these animals. They published their results in Frontiers in Marine Science.

“We show that, far offshore, oceanic manta rays are capable of diving to depths greater than 1,200 meters, far deeper than previously thought,” says first author Dr. Calvin Beale, who completed his Ph.D. at Murdoch University.

Compact laser-plasma accelerator can generate muons on demand for imaging

Muon beams can now be created in a device that is the length of a ruler.

Researchers at Berkeley Lab presented a foot-long (30 cm) compact laser-plasma accelerator (LPA) that can generate and detect highly directional muon beams. It works by using intense laser pulses to accelerate electron beams, which then create muons in significantly higher numbers and with greater directionality, providing a powerful new alternative for non-destructive imaging of large or concealed objects.

Conventional artificial muon sources are bulky and expensive, which has left many imaging applications reliant on naturally occurring, scarce, and unreliable cosmic rays. The new LPA overcomes these constraints by producing significantly higher muon yields, slashing exposure times from months to minutes, according to the study published in Physical Review Accelerators and Beams.

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