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Malaria is found in more than 90 countries around the world, causing 241 million cases and an estimated 627,000 deaths every year. Vaccines are one intervention that could help eliminate this deadly disease, yet a highly effective vaccine remains elusive. Recent technological advances in vaccine development–such as the mRNA vaccines for SARS-CoV2–could lead to a new generation of malaria vaccines.

Now, a research team led by George Washington University has developed two mRNA candidates that are highly effective in reducing both and transmission. The team also found that the two experimental vaccines induced a powerful immune response regardless of whether they were given individually or in combination. The study was published today in npj Vaccines, an open-access that is part of the Nature Portfolio.

“Malaria elimination will not happen overnight but such vaccines could potentially banish from many parts of the world,” Nirbhay Kumar, a professor of global health at the George Washington University Milken Institute School of Public Health, said. “The mRNA vaccine technology can really be a game changer. We saw how successful this technology was in terms of fighting COVID and for this study we adapted it and used it to develop tools to combat malaria.”

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The protests in China have had no impact on Beijing’s ambitions of world domination. On Tuesday, Chinese jets violated South Korea’s Air defence zone. A Pentagon report further claims China will have 1,500 nuclear warheads by 2035. Priyanka Sharma reports.

#Gravitas #China #Nuclear.

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Dr. Jennifer A. Fogarty, Ph.D. (https://www.bcm.edu/people-search/jennifer-fogarty-100936) is the Chief Scientific Officer for the Translational Research Institute for Space Health (TRISH — https://www.bcm.edu/academic-centers/space-medicine/translat…-institute) at Baylor College of Medicine, and the Director of the Applied Health and Performance at Sophic Synergistics LLC.

As Chief Scientist of TRISH, Dr. Fogarty leads an innovative and high-risk research and technology development portfolio to address the most challenging human health and performance risks of space exploration.

At Sophic Synergistics, which is a women-owned and women-led Human Centered Design firm specializing in integrating human factors engineering and human health and performance into a business model, Dr. Fogarty’s Division focuses on developing and expanding the application of medical technologies for use in remote medicine, telemedicine, and home healthcare.

In both roles, Dr. Fogarty’s goal is to increase access to high quality healthcare and empower patients and medical providers by incorporating precision medicine and cutting-edge science and technology with actionable data both in space and on Earth.

Dr. Fogarty has over twenty years of experience in medical physiology and extreme environments and was the NASA Human Research Program Chief Scientist. Her approach prioritizes communication and collaboration with industry academia, government and commercial spaceflight programs, and international partners. She values and seeks collaborations with external institutions and government agencies to assess fundamental and mechanistic discoveries as well as innovative prevention and treatment strategies for application to preserve health and performance.

Dr. Fogarty has a Ph.D. in Medical Physiology from Texas A&M University School of Medicine and a B.S. in Biology from Stockton University. She is currently an Assistant Professor in the Department of Medicine at Baylor College of Medicine, an editor of the Fundamentals of Aerospace Medicine 4th and 5th edition, and associate editor for the journal npj Microgravity.

Continue reading “Dr. Jennifer Fogarty, Ph.D. — Baylor — Innovations To Safeguard Health & Performance In Deep Space” | >

In our cells, the language of DNA is written, making each of us unique. A tandem repeat occurs in DNA when a pattern of one or more nucleotides—the basic structural unit of DNA coded in the base of chemicals cytosine ©, adenine (A), guanine (G) and thymine (T)—is repeated multiple times in tandem. An example might be: CAG CAG CAG, in which the pattern CAG is repeated three times.

Now, using state-of-the-art whole-genome sequencing and machine learning techniques, the UNC School of Medicine lab of Jin Szatkiewicz, Ph.D., associate professor of genetics, and colleagues conducted one of the first and the largest investigations of repeats in , elucidating their contribution to the development of this devastating disease.

Published in the journal Molecular Psychiatry, the research shows that individuals with schizophrenia had a significantly higher rate of rare tandem repeats in their genomes—7% more than individuals without schizophrenia. And they observed that the tandem repeats were not randomly located throughout the genome; they were primarily found in genes crucial to brain function and known to be important in schizophrenia, according to previous studies.

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Scientists have, for the first time, developed a quantum experiment that allows them to study the dynamics, or behavior, of a special kind of theoretical wormhole. The experiment has not created an actual wormhole (a rupture in space and time), rather it allows researchers to probe connections between theoretical wormholes and quantum physics, a prediction of so-called quantum gravity. Quantum gravity refers to a set of theories that seek to connect gravity with quantum physics, two fundamental and well-studied descriptions of nature that appear inherently incompatible with each other.

“We found a that exhibits key properties of a gravitational wormhole yet is sufficiently small to implement on today’s quantum hardware,” says Maria Spiropulu, the principal investigator of the U.S. Department of Energy Office of Science research program Quantum Communication Channels for Fundamental Physics (QCCFP) and the Shang-Yi Ch’en Professor of Physics at Caltech. “This work constitutes a step toward a larger program of testing quantum gravity physics using a quantum computer. It does not substitute for direct probes of quantum gravity in the same way as other planned experiments that might probe quantum gravity effects in the future using quantum sensing, but it does offer a powerful testbed to exercise ideas of quantum gravity.”

The research will be published December 1 in the journal Nature. The study’s first authors are Daniel Jafferis of Harvard University and Alexander Zlokapa (BS ‘21), a former undergraduate student at Caltech who started on this project for his bachelor’s thesis with Spiropulu and has since moved on to graduate school at MIT.

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Observations of thousands of galaxies made with the Sloan Digital Sky Survey telescope (pictured) have revealed a giant arc of galaxies, which refutes the theory of their uniform distribution in the Universe. However, the existence of the large-scale structure discovered by astronomers from the UK and the United States needs to be confirmed by other observations to be accepted.

During the virtual conference of the American Astronomical Society, scientists announced the discovery and study of a “Giant Arc,” which consists of ancient galaxies.

Alexia Lopez and her colleagues analyzed the light of about 40,000 distant quasars recorded during the SDSS survey. These are some of the brightest objects in the Universe and are believed to represent the active nuclei of distant galaxies containing supermassive black holes.

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The goal of achieving what is called artificial general intelligence — or the capacity of an engineered system to display human-like general intelligence — is still some time off into the future. Nevertheless, experts in the field of AI have no doubt accomplished some major milestones along the way, including developing AI capable of deep neural reasoning, tactile reasoning, and even AI with rudimentary social skills.

Now, in yet another step toward AI with more human-like intelligence, researchers from IBM, the Massachusetts Institute of Technology and Harvard University have developed a series of tests that would evaluate an AI’s ability to use a machine version of “common sense” — or a basic ability to perceive, understand, and judge in a manner that is shared by nearly all humans.

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