Lifeboat Foundation: Safeguarding Humanity
Toggle light / dark theme

Blog – Page 4,749

The announcement comes from the journal Science, which published Phase 1 results of a small clinical trial for a vaccine technology that aims to cause the body to create a rare kind of cell.

“At the most general level, the trial results show that one can design vaccines that induce antibodies with pre-specified genetic features, and this may herald a new era of precision vaccines,” William Schief, PhD, a researcher at The Scripps Research Institute and study co-author, told the American Association for the Advancement of Science (AAAS).

The study was the first to test the approach in humans and was effective in 97% – or 35 of 36 – participants. The vaccine technology is called “germline targeting.” Trial results show that “one can design a vaccine that elicits made-to-order antibodies in humans,” Schief said in a news release.

Read more | >

Intel released nine research papers at IEDM 2022 that lay the groundwork for future chip designs as the company looks to deliver on its promise of developing processors with over a trillion transistors by 2030.

The research includes new 2D materials for transistors, new 3D packaging technology that narrows the performance and power gap between chiplet and single-die processors to a nearly-imperceptible range, transistors that ‘don’t forget’ when power is removed, and embedded memories that can be stacked directly on top of transistors and store more than one bit per cell, among other innovations.

Read more | >

Tiny antenna-like organelles once thought to be holdovers from our ancient past appear to play a crucial role in keeping track of time, according to a recent study on mice by researchers from the University of California, Irvine (UCI), in the US. Known as cilia, the microtubule projections can be found throughout the more complex branches of the tree of life, including on many of our own cells.

Read more | >

Aging inevitably increases the risk of disease, as exemplified by CAD, AD, and cancer. Monitoring the aging process and understanding its mechanisms will not only enhance early diagnoses, it may also provide strategies for the early prevention and treatment of diseases. While biomarkers for cellular senescence in in vitro cultured mammalian cells are already well-defined, those that define in vivo senescence/aging at the systemic level remain scarce. Here, we generated a targeted Glb1+/m allele at the Glb1 locus that encodes β-galactosidase. The GAC signal indicates Glb1 level. The results reveal that the live-imaged GAC signal is linearly correlated with chronological age, but only in middle-aged mice (9–13 months). High GAC at the MA stage was associated with cardiac hypertrophy and shortened lifespan. Moreover, GAC signal was exponentially increased in pathological lung fibrosis induced by BLM. Thus, this in vivo reporter mouse can faithfully monitor systemic aging and organ functional decline in a manner closely associated with lifespan, and provides an ideal system for studying aging mechanisms and developing anti-aging manipulations.

The upregulation of p16Ink4a transcription and elevated SAβ-gal staining are both well-established and widely used biomarkers for cellular senescence17, and the former led to the generation of live-imaging aging reporter mice20,22,23. Intriguingly, high level of p16Ink4a, indicated by luciferase activity, predicts cancer initiation rather than lifespan. Similarly, the in vivo application of SAβ-gal as a senescence marker at the tissue level is also limited. Positive SAβ-gal-staining is easy to obtain in kidney and adipose tissue sections but difficult to obtain in blood vessel and heart sections. By SAβ-gal staining, not many positive cells were detected in old individuals26. It raises the question of whether SAβ-gal labels in vivo senescence or if the percentage of in vivo senescent cells is indeed very low.

Read more | >

‘Pangeos’ is a turtle-shaped ‘terayacht,’ a giant floating city imagined by Italian firm Lazzarini Design Studio. While it only exists as a rendering for now, upon completion it could be the largest floating structure in the world. #yahoofinance.

Don’t Miss: Valley of Hype: The culture that built Elizabeth Holmes.
WATCH HERE:

About Yahoo Finance:
At Yahoo Finance, you get free stock quotes, up-to-date news, portfolio management resources, international market data, social interaction and mortgage rates that help you manage your financial life.

Yahoo Finance Plus: With a subscription to Yahoo Finance Plus get the tools you need to invest with confidence. Discover new opportunities with expert research and investment ideas backed by technical and fundamental analysis. Optimize your trades with advanced portfolio insights, fundamental analysis, enhanced charting, and more.
To learn more about Yahoo Finance Plus please visit: https://yhoo.it/33jXYBp.

Connect with Yahoo Finance:
Get the latest news: https://yhoo.it/2fGu5Bb.
Find Yahoo Finance on Facebook: http://bit.ly/2A9u5Zq.
Follow Yahoo Finance on Twitter: http://bit.ly/2LMgloP
Follow Yahoo Finance on Instagram: http://bit.ly/2LOpNYz.
Follow Yahoo Finance Premium on Twitter: https://bit.ly/3hhcnmV

Read more | >

It was a simple idea—maybe even too simple to work.

Research scientist James Ponder and a team of Georgia Tech chemists and engineers thought they could design a transparent polymer film that would conduct electricity as effectively as other commonly used materials, while also being flexible and easy to use at an industrial scale.

They’d do it by simply removing the nonconductive material from their conductive element. Sounds logical, right?

Read more | >

In recent years, many smartphone users have become concerned about the privacy of their data and the extent to which companies might have access to this data. As things stand today, the applications that users can run on their phone and what they can do with these applications is determined by a few big tech companies.

Researchers at ETH Zurich have recently set out on a quest to change this current trend, through the development of a new smartphone architecture called TEEtime. This architecture, introduced in a paper pre-published on arXiv, allows users to flexibly choose what resources on their smartphone they will dedicate to legacy operating systems, such as Android or iOS, and which they wish to keep for their own and data.

“This work was inspired (in part) by our experiences in developing (Swiss) contact tracing applications, where we quickly noticed how limited we are as researchers/developers in accessing some basic services on ‘our’ phones,” Srdjan Capkun, one of the researchers who carried out the study, told TechXplore.

Read more | >

A team of researchers at DeepMind Technologies Ltd., has created an AI application called “DeepNash” that is able to play the game Stratego at an expert level. In their paper published in the journal Science, the group describes the unique approach they took to improve the app’s level of play.

Stratego is a two-player board game and is considered to be difficult to master. The goal for each player is to capture their opponent’s flag, which is hidden among their initial 40 game pieces. Each of the game pieces is marked with a power ranking—higher-ranked players defeat lower-ranked players in face-offs. Making the game more difficult is that neither player can see the markings on the opponent’s game pieces until they meet face-to-face.

Prior research has shown that the complexity of the game is higher than that of chess or go, with 10535 possible scenarios. This level of complexity makes it extremely challenging for computer experts attempting to create Stratego-playing AI systems. In this new effort, the researchers took a different approach, creating an app capable of beating most human and other AI systems.

Read more | >