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The small-scale FDA-cleared trial is designed to evaluate both the safety and initial efficacy of RB-ADSCs in nine patients with Alzheimer’s. Regeneration Biomedical’s CTAD presentation focused on the first three enrolled patients, who each received a single dose of RB-ADSCs delivered directly into the lateral ventricles of the brain using an “Ommaya reservoir” – a device implanted under the scalp to bypass the blood-brain barrier, a major obstacle in Alzheimer’s treatments.

Biomarker analysis at the 12-week mark demonstrated reductions in both p-Tau and amyloid-beta – two proteins strongly associated with Alzheimer’s disease progression. In cerebrospinal fluid (CSF) samples from the three patients, p-Tau levels decreased to “normal” levels, while amyloid PET scans also showed a reduction in amyloid buildup.

Regeneration Biomedical also reported its treatment produced signs of cognitive improvement, with two of the three patients showing increased Mini-Mental State Examination (MMSE) scores, a common measure of cognitive function.

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In a groundbreaking Nature paper, researchers have developed synthetic regulatory sequences that could prevent targeted gene therapies from having effects in unwanted cell types.

More than methylation

While methylation is the most well-known regulator of gene expression, it isn’t the only thing that determines what is to be expressed when. Cis-regulatory elements (CREs), so called because they sit near the DNA sequences they regulate, are responsible for expressing the genes that are specific to each cell type [1]. While they are technically non-coding, as they do not directly code for functional proteins, CREs are critical to epigenomic function.

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Murata is branching out from its usual ceramic components with the launch of flexible, stretchable electronics — a Stretchable Printed Circuit (SPC) platform it says is ideally positioned for wearable and medical devices.

In recent years, in the medical field, to make more accurate diagnoses, the…

Bendy, soft, stretchy devices target the wearable and medical markets.

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Researchers at the Large Hadron Collider (LHC), the world’s largest particle accelerator, have recently made a groundbreaking advancement in exploring the laws of nature. They have observed the phenomenon of quantum entanglement between top quarks, the heaviest elementary particles, at unprecedented energy levels. This breakthrough paves the way for new possibilities in particle physics and could unveil new aspects of the fundamental forces that govern the universe.

Quantum Entanglement: A Counterintuitive Phenomenon

Quantum entanglement is one of the most enigmatic phenomena in quantum mechanics. It occurs when two or more particles become interconnected in such a way that the state of one particle instantly influences another, regardless of the distance separating them. This defies our everyday intuition and challenges some classical physics concepts, like causality.

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Ever noticed how you catch a falling glass before it even registers that it’s slipping? That’s because your brain is constantly making predictions, keeping you one step ahead of reality.

As difficult as it may be to believe, our minds don’t just process what’s happening — they anticipate what’s about to happen next.

This intriguing concept comes from researchers Christian Keysers and Valeria Gazzola of the Netherlands Institute for Neuroscience, along with Giorgia Silani from the University of Vienna.

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Dr. Abba Zubair, MD: “Our hope is to study these space-grown cells to improve treatment for age-related conditions such as stroke, dementia, neurodegenerative diseases and cancer.”

What can microgravity teach us about stem cell growth? This is what a recent study published in NPJ Microgravity hopes to address as a pair of researchers from the Mayo Clinic investigated past research regarding the growth properties of stem cells, specifically regeneration, differentiation, and cell proliferation in microgravity and whether the stem cells can maintain these properties after returning to Earth. This study holds the potential to help researchers better understand how stem cell growth in microgravity can be transitioned into medical applications, including tissue growth for disease modeling.

“The goal of almost all space flight in which stem cells are studied is to enhance growth of large amounts of safe and high-quality clinical-grade stem cells with minimal cell differentiation,” said Dr. Abba Zubair, MD, who is a faculty at the Mayo Clinic and the sole co-author on the study. “Our hope is to study these space-grown cells to improve treatment for age-related conditions such as stroke, dementia, neurodegenerative diseases and cancer.”

For the study, the researchers examined past research that launched stem cell cultures to the International Space Station (ISS) to have astronauts onboard evaluate the stem cells’ growth patterns and behavior under microgravity conditions. Dr. Zunair has launched stem cells to the ISS on three occasions and the various types of stem cells examined on the ISS in previous research include mesenchymal stem cells, hematopoietic stem cells, cardiovascular progenitor stem cells, and neural stem cells.

Continue reading “Space-Born Stem Cells: A New Frontier in Regenerative Medicine” | >

USC researchers have developed a new process to upcycle the composite materials appearing in automobile panels and light rail vehicles, addressing a current environmental challenge in the transportation and energy sectors. The study recently appeared in the Journal of the American Chemical Society.

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When the ‘God of chaos’ asteroid Apophis makes an ultraclose flyby of Earth in 2029, our planet’s gravity may trigger tremors and landslides that totally change the asteroid’s surface.

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