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To realize electronic operations beyond the von Neumann bottleneck, a new type of switch that can mimic self-learning is needed. Here, the authors demonstrate all-in-one-place logic and memory operations based on dynamic molecular switch that can emulate brain-like synaptic and Pavlovian response, bringing the field a step closer to molecular-scale hardware.

It is easier to form more substituted carbocations because of destabilisation in the parent substrate, rather than stabilisation in the reactive intermediate, new research shows.1

Many organic transformations involve carbocations as reactive intermediates. These are usually formed via a heterolytic C–X bond dissociation to give a carbocation C+ and an anion X-. Current understanding is that the bond dissociation energy decreases with increased methyl substitution because of the stabilising effect of the methyl groups, as well as relief due to steric repulsion: going from substrate to carbocation gives the substituents proportionally more room in a more substituted system. However, a team in the Netherlands, led by Matthias Bickelhaupt at VU Amsterdam, has investigated this from a different angle.

Researchers at Karolinska Institutet in Sweden have identified the bacteria most commonly found in severe oral infections. Few such studies have been done before, and the team now hopes that the study can provide deeper insight into the association between oral bacteria and other diseases. The study is published in Microbiology Spectrum.

Previous studies have demonstrated clear links between and , such as cancer, , diabetes and Alzheimer’s disease. However, there have been few identifying which occur in infected oral-and maxillofacial regions. Researchers at Karolinska Institutet have now analyzed samples collected between 2010 and 2020 at the Karolinska University Hospital in Sweden from patients with severe oral infections and produced a list of the most common bacteria.

This was a collaborative study that was performed by Professor Margaret Sällberg Chen and adjunct Professor Volkan Özenci’s research groups.