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Biologists identify targets for new pancreatic cancer treatments

Researchers from MIT and Dana-Farber Cancer Institute have discovered that a class of peptides expressed in pancreatic cancer cells could be a promising target for T-cell therapies and other approaches that attack pancreatic tumors.

Known as cryptic peptides, these molecules are produced from sequences in the genome that were not thought to encode proteins. Such peptides can also be found in some healthy cells, but in this study, the researchers identified about 500 that appear to be found only in pancreatic tumors.


Cryptic peptides, which are expressed in pancreatic cancer cells, could be promising targets for T-cell therapies that attack pancreatic tumors, according to a study from MIT and the Dana-Farber Cancer Institute.

Northeastern researchers identify proteins receptive to treating ovarian cancer

Researchers at Northeastern University have identified two proteins abundant on drug-resistant ovarian cancer cells that become receptive to chemotherapy when treated with light.

Published in the journal Photochemistry and Photobiology, the research findings represent promising progress in the treatment of one of the most deadly forms of cancer. By targeting cancer cells with photo-sensitive antibodies and then shining light on them, researchers have made previously untreatable tumors receptive to drugs.

(This may be a repost, but still cool. Reposts are cool because it is a sign of something to pay attention to.)


Researchers have developed a light-based ovarian cancer therapy that makes tumors more receptive to chemotherapy.

Study finds viruses rely on diverse RNA traits to pack their genomes with precision

Researchers at San Diego State University and Michigan State University are shedding new light on how viruses meticulously pack their genetic material — a breakthrough that could help researchers engineer antivirals and gene therapies.

The future of AI is human: Rice, Baylor College of Medicine to lead Center for Humanities-based Health AI Innovation

CHHAIN, supported by a $500,000 NEH grant, will serve as a central hub for exploring how humanities-based insights, particularly those grounded in ethics, history and patient narratives, can shape the future of responsible AI in health care.

Exercise and the Organ-Brain Axis: Regulation of Neurological Disorders by Emerging Exerkines

Research on exercise and brain disorders has traditionally focused on its direct regulatory effects on neurons and synapses, neglecting peripheral organ-mediated pathways. To address this gap, this review proposes the novel concept of the “multi-organ-brain axis.” This concept posits that during brain disorders, functional alterations in peripheral organs such as skeletal muscle, heart, liver, adipose tissue, and spleen can disrupt metabolic and immune homeostasis, thereby bidirectionally modulating brain function via signaling molecules and metabolites.

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