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The Lifeboat Foundation Guardian Award is annually bestowed upon a respected scientist or public figure who has warned of a future fraught with dangers and encouraged measures to prevent them.

For the first time since 2006, we have two joint recipients of the Lifeboat Foundation Guardian Award. This year’s recipients are Jerome C. Glenn and Volodymyr Zelenskyy, who are defending against world existential risks and country existential risks, respectively.


Jerome C. Glenn and Volodymyr Zelenskyy are winners of the 2022 Guardian Award.

To learn to socialize, zebrafish need to trust their gut.

Gut microbes encourage specialized cells to prune back extra connections in brain circuits that control social behavior, new University of Oregon research in zebrafish shows. The pruning is essential for the development of normal social behavior.

The researchers also found that these ‘social’ neurons are similar in zebrafish and mice. That suggests the findings might translate between species — and could possibly point the way to treatments for a range of neurodevelopmental conditions.

Summary: By inhibiting NMDA receptors, ketamine increases noise to gamma frequencies in one layer of the thalamic nucleus and one lay of the somatosensory cortex. Findings suggest psychosis may be triggered by an increase in background noise impairing thalamocortical neurons which may be caused by a malfunction in NMDA receptors affecting the balance of inhibition and excitation in the brain.

Source: HSE

An international team of researchers including Sofya Kulikova, Senior Research Fellow at the HSE University-Perm, found that ketamine, being an NMDA receptor inhibitor, increases the brain’s background noise, causing higher entropy of incoming sensory signals and disrupting their transmission between the thalamus and the cortex.

The whole interview is good and informative but starts with Sinclair commenting that at the moment he thinks living to 150 is possible in our lifetimes but not immortality. But given that, I’m 51. If I’m going to live potentially another century the technology will get better and better in that century and I would fully expect to life spans to become what we want rather than what we have to accept.


In this Ask Me Anything session, David and Peter discuss the latest age-reversal breakthroughs, getting approval from the FDA, and the possibility of living forever.
David Sinclair is a biologist and academic known for his expertise in aging and epigenetics. Sinclair is a genetics professor and the Co-Director of Harvard Medical School’s Paul F. Glenn Center for Biology of Aging Research. He’s been included in Time100 as one of the 100 Most Influential People in the World, and his research has been featured all over the media. Besides writing a New York Times Best Seller, David has co-founded several biotech companies, a science publication called Aging, and is an inventor of 35 patents.
Read David’s book, Lifespan: Why We Age-and Why We Don’t Have To: https://a.co/d/85H3Mll.

This episode is brought to you by Levels: real-time feedback on how diet impacts your health. https://levels.link/peter.

Consider a journey to optimize your mind and body by visiting http://mylifeforce.com/peter.

Read the Tech Blog: https://www.diamandis.com/blog.

This segment originally aired on December 28, 2022.
Colin Rusch, Oppenheimer & Co. Managing Director and Senior Research Analyst, sits down with Yahoo Finance Live anchors Seana Smith and Jared Blikre to talk about Tesla’s stock outlook in 2023 following Elon Musk’s invested interest in managing Twitter this past year.
Don’t Miss: Valley of Hype: The culture that built Elizabeth Holmes.
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In a new study, scientists say they can explain dark matter by positing a particle that links to a fifth dimension.

(Updated version of the previous article.)

While the “warped extra dimension” (WED) is a trademark of a popular physics model first introduced in 1999, this research, published in The European Physical Journal C, is the first to cohesively use the theory to explain the long-lasting dark matter problem within particle physics.