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While shedding and symptom may not be closely linked in general, we found total shedding and symptom severity to be highly correlated (Pearson 0.81, Supplementary Fig. S1). Furthermore, with one exception, low shedding implied low symptom severity and vice versa. Thus associations found between shedding and pre-inoculation biomarkers like the CPV are also present in symptom severity, although to a lesser degree. Therefore in the rest of this section we report associations for the less noisy shedding measurements. The total variance explained (\(R^2\) ) by a linear model relating CPV score to shedding titers is \(R^2=0.77\) (ratio of residual variance of linear regression to variance of titers). Furthermore, a logistic regression of total shedding onto the CPV score yielded a perfect discriminant between high and low shedders, respectively defined as those whose total shedding is below versus above the population median.

The correlation between shedding titers and CPV scores is robust to reductions in the number of NCPT variables composing the score. In fact the correlation between shedding and CPV increases to greater than 0.9 when only 6 NCPT measures are incorporated: digSym-time, digSym-correct, reaction-time, posner-tutorialTime, trail-time and trail-tutorialTime. Furthermore, the CVP score incorporating only the three basic NCPT measures digSym-time, digSym-correct, trail-time achieves a correlation level of approximately 0.7 (Fig. S2). We find that adding a fourth basic NCPT variable reaction time to the CPV score computation does not appreciably affect this level of correlation. On the other hand, replacing replacing either digSym-time or digSym-correct with posner-tutorialTime produces an increase in correlation to a level greater than 0.85.

To illustrate the role of the 18 individual NCPT variables in the CPV, we plot in Fig. 1e the univariate CPV scores for the two lowest shedding and the two highest shedding participants. This figure is extracted from Fig. S3 in the Supplementary that shows the sequence of univariate CPV scores for all 18 study participants. Superimposed on the plot of these variables is a boxplot indicating score sensitivity to session perturbation, determined by leave-one-out analysis where the univariate CPV was recomputed after successively leaving a single NCPT session out of each participant’s sequence (sans screening session). Figure 1e clearly shows that certain NCPT variables have significantly higher variability for the high shedders (lower two panels) than for the low shedders (top two panels). Note that the NCPT variable with highest variability (variable achieving peak score in each panel of Fig. 1e) differs across study participants.

The ability to transmit and manipulate, with minimal loss, the smallest unit of light—the photon—plays a pivotal role in optical communications as well as designs for quantum computers that would use light rather than electric charges to store and carry information.

Now, researchers at the National Institute of Standards and Technology (NIST) and their colleagues have connected, on a single microchip, quantum dots—artificial atoms that generate individual photons rapidly and on-demand when illuminated by a laser—with miniature circuits that can guide the light without significant loss of intensity.

To create the ultra-low-loss circuits, the researchers fabricated silicon-nitride waveguides—the channels through which the photons traveled—and buried them in silicon dioxide. The channels were wide but shallow, a geometry that reduced the likelihood that photons would scatter out of the waveguides. Encapsulating the waveguides in silicon dioxide also helped to reduce scattering.

Year 2017 19,000,000,000,000,000,000,000 possible earth like planets in the universe ✨️ 💖 🙏 ❤️


How do scientists know that there are billions of other solar systems like us in the Universe? originally appeared on Quora: the place to gain and share knowledge, empowering people to learn from others and better understand the world.

Answer by Robert Frost, Instructor and Flight Controller at NASA, on Quora:

How do scientists know that there are billions of other solar systems like us in the Universe?

They don’t know that, and I’ve never come across one that made that claim.