Lifeboat Foundation

A synthetic system that reproduces several attributes of living cells.

Intellia Therapeutics said Friday the first six patients to receive its CRISPR-based treatment for a genetic swelling disorder have safely had small, corrective changes made to dysfunctional DNA inside their liver cells.

Preliminary results from the study — just the second to show that CRISPR-based gene editing can be delivered systemically and performed in vivo, or inside the body — found that the treatment, NTLA-2002, reduced levels of the disease-causing protein, kallikrein, by 65% and 92% in the low-and high-dose cohort, respectively. In the low-dose group, the one-time infusion also reduced by 91% the painful swelling “attacks” commonly experienced by patients with a rare condition called hereditary angioedema, or HAE. Participants in the high-dose group have not yet completed the 16-week observation period.

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Hello and welcome! My name is Anton and in this video, we will talk about.
Links:
https://www.science.org/doi/10.1126/science.1060182
https://arxiv.org/pdf/1609.01639.pdf.
https://www.nsf.gov/news/mmg/mmg_disp.jsp?med_id=59577&from=
https://www.rle.mit.edu/cua_pub/ketterle_group/Projects_2001…Vortex.htm.
https://dx.doi.org/10.1103/PhysRevLett.129.061302
ISS experiments: https://youtu.be/UEEccJLYVXM
Another similar finding: https://youtu.be/FsTbMfQP7b0
#quantumphysics #blackhole #vortex.

Continue reading “Black Holes May Be Covered in Vortex Structures According to New Study” »

Although we think we are fully aware and in control of our everyday decisions, we actually often follow a series of cognitive scripts. These cognitive scripts often develop in childhood and are personal to you. However, as they are commonly based on a sequence of events that we expect to occur in given situations, many scripts will follow a common theme.

For example, when meeting someone new, we know we are expected to give our name, ask the individual about themselves, partake in some small talk, and then move onto deeper topics. Although cognitive scripts can save time and reduce the mental effort of deciding how to behave, they can also negatively affect our decision-making and productivity.

The research community is excited about the potential of DNA to function as long-term archival storage. That’s largely because it’s extremely dense, chemically stable for tens of thousands of years, and comes in a format we’re unlikely to forget how to read. While there has been some interesting progress, efforts have mostly stayed in the research community because of the high costs and extremely slow read and write speeds. These are problems that need to be solved before DNA-based storage can be practical.

So we were surprised to hear that storage giant Seagate had entered into a collaboration with a DNA-based storage company called Catalog. To find out how close the company’s technology is to being useful, we talked to Catalog’s CEO, Hyunjun Park indicated that Catalog’s approach is counterintuitive on two levels: It doesn’t store data the way you’d expect, and it isn’t focusing on archival storage at all.

Quantum simulators made from solid-state systems.

The new Pew Research Center report found a surge of adults leaving Christianity to become atheist, agnostic, or “nothing in particular.”

CAR-T immune therapies were developed to fight cancer. The same technique just showed promise treating lupus, but it costs hundreds of thousands.

Circa 2008 face_with_colon_three

Adult bone marrow (BM) houses a tiny pool of hematopoietic stem cells (HSCs) that have the ability to maintain not only themselves but also all the rest of highly turning over blood lineages throughout the mammalian life (1, 2). Hence, the ability to sustain HSC in tissue culture would allow serial introduction of gain or loss of function mutations efficiently in hematopoietic system. However, our failure to expand HSC in culture has hampered the use of this approach. In fact, BM suspension cultures lose rapidly their HSC content despite vigorous growth of progenitors and more differentiated cells at least for 3 weeks even in optimal cytokine milieu (3, 4). Therefore, the phenomenon of stem cell exhaustion or senescence may set the limits that make it impossible even in principle to expand HSC in culture for longer periods (5–7).

Mouse HSC do expand in vivo (8, 9), at least up to 8000-fold, as shown by Iscove and Nawa (9) through serial transplantation experiments that assessed carefully the input and output contents of HSC in each transfer generation. Recently also in vitro approaches have been improved and refined culture conditions with new growth factors can now support up to 30-fold expansion of mouse HSC ex vivo (10). However, since it is not clear to what extent external culture conditions can be improved, alternative but not mutually exclusive efforts to change the intrinsic properties of HSC have been taken. Seminal experiments in this respect by Humphries, Savageau and their colleagues have shown that ectopic expression of HOXB4 transcription factor in BM cells support the survival and expansion of HSC in vivo and importantly also in vitro (11–13). By rigorously monitoring the HSC content in their cultures of HOXB4-transduced BM cells, they found that HSC could be expanded up to 41-fold in the 2-week liquid cultures (13). HOXB4 belongs to a large family of HOX transcription factors that are crucial for the basic developmental processes in addition to their role in maintenance of different stem cell compartments.

Continue reading “Manipulation of immune system via immortal bone marrow stem cells” »