Lifeboat Foundation

No one imaging mode can catch everything that’s going on inside the brain, since it is such a complex organ. Multiple “brain maps” have emerged over the years, with each focusing on different brain processes, from metabolism to cognitive function. These maps are indeed important, but using them in isolation limits the discoveries scientists can make from them.

More than forty existing brain maps have now been collected in one place by a team from The Neuro. Called neuromaps, the database will help researchers find correlations between patterns across different brain regions, modalities, spatial scales, and brain functions. To assist researchers in differentiating between a relevant association and a random pattern, it offers a standardized space to see each map in comparison to one another and evaluates the statistical significance of these comparisons. Additionally, the neuromaps database helps standardize the code across maps, to improve reproducibility of results.

BYU engineers design a molten-salt reactor that will never melt down and fits on a flatbed truck.

Developed at Brigham Young University, the micro-reactor can fit on a flatbed truck and produce enough energy to power 1,000 homes.

Sending rockets into space requires sacrificing expensive equipment, burning massive amounts of fuel, and risking potential catastrophe. So in the space race of the 21st century, some engineers are abandoning rockets for something more exciting: elevators. What would it take to build such a structure? Fabio Pacucci explores the physics behind modern space elevators. [Directed by Tjoff Koong Studios, narrated by Addison Anderson].

An exploration of what I think is one of the spookiest solutions to the Fermi Paradox that could explain SETI’s great silence.

My new clips and live channel:

Continue reading “Fermi Paradox: The Malevolent Alien Megabrain Scenario” »

Richard Gott, co author with Neil De Grasse Tyson of “Welcome to The Universe” argues the key to understanding the origin of the universe may be the concept of closed time like curves. These are solutions to Einstein’s theory that may allow time travel into the past. in this film, Richard Gott of Princeton University explains the model he developed with LIxin Li. Gott explores the possibility of a closed time like curve forming in the early universe and how this might lead to the amazing property of the universe being able to create itself. Gott is one of the leading experts in time travel solution to Einstein’s equations and is author of the book “Time Travel In Einstein’s Universe”.
This film is part of a series of films exploring competing models of th early universe with the creators of those models. We have interviewed Stephen Hawking, Roger Penrose, Alan Guth and many other leaders of the field. To see other episodes, click on the link below:
https://www.youtube.com/playlist?list=PLJ4zAUPI-qqqj2D8eSk7yoa4hnojoCR4m.

We would like to thank the following who helped us are this movie:
Animations:
Morn 1415
David Yates.
NASA
ESA
M Buser, E Kajari, and WP Schleich.
Storyblocks.
Nina McCurdy, Anthony Aguirre, Joel Primack, Nancy Abrams.
Pixabay.
Ziri Younsi.

Continue reading “Before the Big Bang 6: Can the Universe Create Itself?” »

One of the hallmarks of aging, cellular senescence is what happens when aging cells do not die in the usual way (a process known as apoptosis) and start to accumulate in our bodies. The accumulation of these “senescent” cells is implicated in diseases including dementias, atherosclerosis, cancers, diabetes and arthritis. But senescence is not just part of the aging process – it tends to occur in individuals who develop frailty and multiple illnesses, and this can occur at any point during life.

In 2015, a team of researchers at the Mayo Clinic, led by Dr James L Kirkland, published a seminal paper in Aging Cell that introduced a new class of drugs called senolytics. Based on the idea that removing senescent cells may enhance human healthspan, these drugs were identified based on their ability to selectively target and eliminate those cells.

Longevity. Technology: Since the discovery of the first senolytics, hundreds of others have since been identified or created, and senotherapeutics is now one of the hottest areas in longevity, with a host of clinical trials under way and companies pursuing senolytic therapies for a range of age-related conditions. But what does the man who started it all think about the therapeutic field he helped create? In the first of two articles, we bring you Dr Kirkland’s unique perspective on the world of senolytics.

Scientists have discovered what turns off the molecular alarm system that plays a critical role in our immune response.

The antibacterial superhero MR1 (MHC class I-related molecule) is a protein found in every cell of the human body that functions as a molecular alarm system, alerting powerful cells of our immune system, our white blood cells, when cancer or bacterial infection is present.

While prior groundbreaking research revealed the cellular machinery that MR1 depends on to activate, nothing was understood about how the MR1 alarm is “turned off” until now.

New research from the University of Cincinnati bolsters a hypothesis that Alzheimer’s disease is caused by a decline in levels of a specific protein, contrary to a prevailing theory that has been recently called into question.

UC researchers led by Alberto Espay, MD, and Andrea Sturchio, MD, in collaboration with the Karolinska Institute in Sweden, published the research on Oct. 4 in the Journal of Alzheimer’s Disease.

The research is focused on a protein called amyloid-beta. The protein normally carries out its functions in the brain in a form that is soluble, meaning dissolvable in water, but it sometimes hardens into clumps, known as amyloid plaques.

One of the powerful features of big language models, such as GPT-3, comes from its ability to learn after it has been trained and without being updated. You simply feed it a few examples of input and…