The “most complicated therapy ever” tailors bespoke, genome-edited immune cells to attack tumors.
About 450 light years away, a star is being born. The James Webb Space Telescope (JWST) has taken an image of a protostar – an object that is massive enough to become a star but hasn’t yet begun the process of nuclear fusion – revealing details that have never been seen before.
This protostar is in an area called the Taurus star-forming region, embedded within a dark cloud of dust and gas called L1527. It is only about 100,000 years old, putting it in the first stage of star formation, in which it is still slightly fluffy and lopsided. Over the next few million years, it will continue to compress under its own gravitational pull and then begin to fuse hydrogen into helium and become a fully fledged star.
Scientists at the Garvan Institute of Medical Research have identified molecular profiles of the surrounding matrix of a common type of lung cancer that might indicate which patients are likely to develop aggressive tumors.
Squamous cell carcinoma is the second most prevalent type of lung cancer. Yet treatment options for these patients remain limited and have remained largely unchanged over decades. High rates of recurrence and chemotherapy resistance mean that less than one in five patients will survive more than five years after their diagnosis.
In addition to studying cancer cells, Garvan researchers have been turning their attention to the environment that surrounds these cancer cells in the tumor. A major component of this environment is the extracellular matrix, a 3D meshwork of around 300 core molecules. This matrix is present in all tissues in the body, where it normally provides structural and functional support to hold cells together. But in cancers, this matrix is fundamentally altered and these changes can promote tumor growth.
“It’s a novel contribution that uses different methods compared to what most people have been doing,” said Steffen Gielen, a cosmologist at the University of Sheffield in the United Kingdom.
The provocative conclusion rests on a mathematical trick involving switching to a clock that ticks with imaginary numbers. Using the imaginary clock, as Hawking did in the ’70s, Turok and Boyle could calculate a quantity, known as entropy, that appears to correspond to our universe. But the imaginary time trick is a roundabout way of calculating entropy, and without a more rigorous method, the meaning of the quantity remains hotly debated. While physicists puzzle over the correct interpretation of the entropy calculation, many view it as a new guidepost on the road to the fundamental, quantum nature of space and time.
According to the researchers, these drugs may effectively prevent dementia in high-risk individuals with mild to moderate type 2 diabetes, and it may now be worthwhile to give them priority in future clinical trials to determine whether they can be repurposed.
Researchers have begun to investigate whether diabetes drugs could potentially help prevent or cure dementia since type 2 diabetes and dementia share several physiological patterns. However, the results have been inconsistent thus far.
The researchers compared the incidence of dementia in older adults with type 2 diabetes who were receiving either sulfonylurea or thiazolidinedione (TZD) with those receiving metformin alone in order to shed further light on this.
A group of researchers recently simulated the event horizon of a man-made black hole in a lab. The new analog could help us learn more about the elusive radiation that is believed to be emitted by real black holes out in space. Black holes are by far one of the most mysterious objects in space.
The massive object at the galaxy’s center is invisible. But this year’s picture of the swirling plasma around its edges will help to reveal more about the galaxy’s history and evolution.
Award-winning UAE property developer Binghatti has joined forces with luxury jewelry and watch brand Jacob & Co to introduce the tallest residential tower in the world, as reported by Design Boom.
Burj Binghatti.
In addition, the interior design of the homes will feature details provided by the global brand itself in its unforgettable and incomparable signature style. The structure will also host a few luxury amenities including an infinity pool overlooking downtown Dubai, a gymnasium and a spa with bespoke services.
Humans to live on the moon
Posted in space travel
The Artemis mission is preparing astronauts for this lofty goal.
Humans are on course to be living and even working on the moon by 2030, a NASA official told BBC’s Sunday.
Howard Hu, the head of the U.S. agency’s Orion lunar spacecraft programme, said astronauts could stay on the celestial object for extended periods of time by the end of this decade.
Nuclear arsenals remain large enough to fundamentally shift the Earth system in the blink of an eye.
The U.S. and Russia have recently agreed to hold talks on the New START Treaty, and the only accord left regulating the two largest nuclear arsenals in the world. While this is undoubtedly good news, we must not allow it to lull us into complacency. Global events this year, most notably in Ukraine, have raised fears of a nuclear conflict to levels not seen since the cold war. More than 10,000 nuclear warheads remain in the world, and the Kremlin’s language regarding weapons of mass destruction has become increasingly threatening in 2022.
Global famine and climate breakdown
In 1982, a group of scientists, including Carl Sagan, began to raise the alarm about a climate apocalypse that could follow a nuclear war. Using simple computer simulations and historic volcanic eruptions as natural analogs, they showed how smoke that lofted into the stratosphere from urban firestorms could block the sun for years.