Lifeboat Foundation

Researchers at the Francis Crick Institute have developed an imaging technique to capture information about the structure and function of brain tissue at subcellular level—a few billionths of a meter, while also capturing information about the surrounding environment.

The unique approach detailed in Nature Communications today (25 May), overcomes the challenges of imaging tissues at different scales, allowing scientists to see the surrounding cells and how they function, so they can build a complete picture of neural networks in the brain.

Various imaging methods are used to capture information about tissue, cells and subcellular structures. However, a single method can only capture information about either the structure or function of the tissue and looking in detail at a nanometer scale means scientists lose information about the wider surroundings. This means that to gain an overall understanding of the tissue, imaging techniques need to be combined.

The human brain is less accessible than other organs because it is covered by a thick, hard skull. As a result, researchers have been limited to low-resolution imaging or analysis of brain signals measured outside the skull. This has proved to be a major hindrance in brain research, including research on developmental stages, causes of diseases, and their treatments. Recently, studies have been performed using primary neurons from rats or human-derived induced pluripotent stem cells (iPSCs) to create artificial brain models that have been applied to investigate brain developmental processes and the causes of brain diseases. These studies are expected to play a key role to unlocking the mysteries of the brain.

In the past, artificial brain models were created and studied in 2D; however, in 2017, a research team from KIST developed a 3D artificial brain model that more closely resembled the real brain. Unfortunately, due to the absence of an analytical framework for studying signals in a 3D brain model, studies were limited to analyses of surface signals or had to reform the 3D structure to a flat shape. As such, tracking neural signals in a complex, interconnected artificial network remained a challenge.

The Korea Institute of Science and Technology (KIST) announced that the research teams of Doctors Il-Joo Cho and Nakwon Choi have developed a analysis system that can apply precise non-destructive stimuli to a 3D artificial neural circuit and measure neural signals in real-time from multiple locations inside the model at the cellular level.

Elementary school-age children who get less than nine hours of sleep per night have significant differences in certain brain regions responsible for memory, intelligence and well-being compared to those who get the recommended nine to 12 hours of sleep per night, according to a new study led by University of Maryland School of Medicine (UMSOM) researchers. Such differences correlated with greater mental health problems, like depression, anxiety, and impulsive behaviors, in those who lacked sleep. Inadequate sleep was also linked to cognitive difficulties with memory, problem solving and decision making. The findings were published today in the journal The Lancet Child & Adolescent Health.

The American Academy of Sleep Medicine recommends that children aged six to 12 years of age sleep 9 to 12 hours per night on a regular basis to promote optimal health. Up until now, no studies have examined the long-lasting impact of insufficient sleep on the neurocognitive development of pre-teens.

To conduct the study, the researchers examined data that were collected from more than 8,300 children aged nine to 10 years who were enrolled in the Adolescent Brain Cognitive Development (ABCD) study. They examined MRI images, medical records, and surveys completed by the participants and their parents at the time of enrollment and at a two-year follow-up visit at 11 to 12 years of age. Funded by the National Institutes of Health (NIH), the ABCD study is the largest long-term study of brain development and child health in the U.S.

A new solar panel design can efficiently convert light into electricity, while still allowing almost 80% of incoming light to pass through.

Watching asteroids can help us prepare for the unfortunate one that might be headed straight towards us and how it can be avoided.

Presently available in France, the “Electric As You Go” program is for private customers who wish to change their old vehicle to an affordable, sustainable one. Trying to break through ‘” the cost is too much to invest in an EV” scenario (which becomes more disputable each hour of each day), Stellantis introduced “Electric As You Go” and is promoting a more affordable long-term rental program dedicated to battery electric vehicles (BEVs).

The program claims it is efficiently designed to offer breakthrough competitive prices to Stellantis customers. The offer is starting in France and looks hopeful.

Continue reading “Trade In Your Old Fossil Car in France & Get An Affordable New Stellantis — ‘Electric As You Go’” »

The solution as to why gravity is so weak may come from taking a closer look at the Higgs boson.

Living organisms offer extensive diversity in terms of their phenotypes, metabolic processes, and adaptation to various niches. However, the basic building blocks that create this diversity are remarkably similar. How can we advance our understanding of the fascinating mechanisms that drive biological complexity and how can we harness biological components to build entirely new materials and devices?

A new Special Issue from ACS Synthetic Biology will focus on this dynamic topic, including contributions that deconstruct as well as build up and mimic biological systems. The resulting work serves both to test our scientific understanding and to extend known biology to develop new concepts and applications. The issue will be led by Associate Editor Michael Jewett with Guest Editors Kate Adamala, Marileen Dogterom, and Neha Kamat.

The table also shows the average normalized rank of transfer learning approaches. Hyperparameter transfer learning uses evaluation data from past HPO tasks in order to warmstart the current HPO task, which can result in significant speed-ups in practice.

Syne Tune supports transfer-learning-based HPO via an abstraction that maps a scheduler and transfer learning data to a warmstarted instance of the former. We consider the bounding-box and quantile-based ASHA, respectively referred to as ASHA-BB and ASHA-CTS. We also consider a zero-shot approach (ZS), which greedily selects hyperparameter configurations that complement previously considered ones, based on historical performances; and RUSH, which warmstarts ASHA with the best configurations found for previous tasks. As expected, we find that transfer learning approaches accelerate HPO.

Our experiments show that Syne Tune makes research on automated machine learning more efficient, reliable, and trustworthy. By making simulation on tabulated benchmarks a first-class citizen, it makes hyperparameter optimization accessible to researchers without massive computation budgets. By supporting advanced use cases, such as hyperparameter transfer learning, it allows better problem solving in practice.