Lifeboat Foundation

The recently identified, globally predominant SARS-CoV-2 Omicron variant (BA.1) is highly transmissible, even in fully vaccinated individuals, and causes attenuated disease compared with other major viral variants recognized to date^{1 – 7}. The Omicron spike (S) protein, with an unusually large number of mutations, is considered the major driver of these phenotypes^3,8. We generated chimeric recombinant SARS-CoV-2 encoding the S gene of Omicron in the backbone of an ancestral SARS-CoV-2 isolate and compared this virus with the naturally circulating Omicron variant. The Omicron S-bearing virus robustly escapes vaccine-induced humoral immunity, mainly due to mutations in the receptor-binding motif (RBM), yet unlike naturally occurring Omicron, efficiently replicates in cell lines and primary-like distal lung cells. In K18-hACE2 mice, while Omicron causes mild, non-fatal infection, the Omicron S-carrying virus inflicts severe disease with a mortality rate of 80%. This indicates that while the vaccine escape of Omicron is defined by mutations in S, major determinants of viral pathogenicity reside outside of S.

The authors have declared no competing interest.

The mechanisms underlying decision-making have been a long-standing focus of neuroscience research. But now, researchers from Japan have found new information about how the reward system in the brain processes risky decisions.

In a study recently published in Nature Communications, researchers from the University of Tsukuba have revealed that individual neurons in the neural circuit that processes reward information fire in accordance with a well-established theory used to describe the decision-making process.

First proposed in the 1970s, prospect theory is a highly influential concept used to describe how people and animals make choices. Although this theory has been supported by thousands of studies, limitations in the temporal and spatial resolution of human neuroimaging techniques have prevented researchers from determining whether the activity of individual neurons follows this pattern, something that the researchers at the University of Tsukuba aimed to address.

The shells of some mollusk species have compact helical structures that researchers propose develop from the self-assembly of a liquid-crystalline material.

Researchers have demonstrated a quantum sensor that can power itself using sunlight and an ambient magnetic field, an achievement that could help reduce the energy costs of this energy-hungry technology.

No longer the realm of science fiction, quantum sensors are today used in applications ranging from timekeeping and gravitational-wave detection to nanoscale magnetometry [1]. When making new quantum sensors, most researchers focus on creating devices that are as precise as possible, which typically requires using advanced—energy-hungry—technologies. This high energy consumption can be problematic for sensors designed for use in remote locations on Earth, in space, or in Internet-of-Things sensors that are not connected to mains electricity. To reduce the reliance of quantum sensors on external energy sources, Yunbin Zhu of the University of Science and Technology of China and colleagues now demonstrate a quantum sensor that directly exploits renewable energy sources to get the energy it needs to operate [2].

Data from the Parker Solar Probe confirms a long-suspected heat source for the Sun’s surprisingly hot corona, but there may be others.

The Sun’s surface temperature is around six thousand degrees kelvin, but the solar atmosphere—the corona and the solar wind—can reach a million degrees kelvin, a long-standing mystery in solar physics. Now, with data from the Parker Solar Probe, researchers have found evidence supporting a partial explanation for this mystery: magnetic waves driven by subsurface turbulence can impart energy to ions in these regions [1].

The exact mechanism of heating has been debated for decades, but the story appears to start with turbulent flow in the Sun’s convection zone, the outermost layer below the surface. In fluid dynamics, turbulence causes heating through a process known as turbulent energy cascade, where large eddies are converted into progressively smaller eddies. The energy in the smallest eddies is converted into heat through collisions between molecules.

You might suppose Hollywood is good at predicting the future. Indeed, Robert Wallace, head of the CIA’s Office of Technical Service and the US equivalent of MI6’s fictional Q, has recounted how Russian spies would watch the latest Bond movie to see what technologies might be coming their way.

Hollywood’s continuing obsession with killer robots might therefore be of significant concern. The newest such movie is Apple TV’s forthcoming sex robot courtroom drama Dolly.

Continue reading “‘Killer Robots’ Are Already Here. They Just Don’t Look Like You Think” »

The husband-and-wife team who co-founded BioNTech, the biotechnology company that partnered with Pfizer to develop an effective messenger-RNA (mRNA) shot against COVID-19, has predicted that a cancer vaccine could be widely available within the next decade.

“Yes, we feel that a cure for cancer, or to changing cancer patients’ lives, is in our grasp,” said Professor Ozlem Tureci during an interview on BBC’s ‘Sunday with Laura Kuenssberg’.

The cancer vaccine, which would build upon breakthroughs achieved by the scientists during the development of the COVID-19 shot, may be widely available within just eight years, said Professor Ugur Sahin.

Summary: Proteins associated with motor neuron disease, or ALS are present in the gut many years before disease pathologies can be found in the brain. A stool sample or gut biopsy could help identify the presence of MND-associated proteins years before symptoms appear.

Source: University of Aberdeen.

The same proteins thought to contribute to motor neuron disease can be found in the gut many years before any brain symptoms occur, a new study by the University of Aberdeen has found.

Cleveland Clinic researchers have identified a common diabetes medication, metformin, as a possible treatment for atrial fibrillation.

The study, published in Cell Reports Medicine, built on ongoing collaborative Cleveland Clinic research to support further investigation into metformin as a drug repurposing candidate. Researchers used advanced computation and genetic sequencing to determine that metformin’s targets overlap significantly with genes dysregulated in atrial fibrillation.

Finding drugs or procedures to treat atrial fibrillation is difficult because of potential serious side effects. There is a significant need for new treatments for atrial fibrillation as there have been no new drugs approved in more than a decade.