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An exploration in nanotechnology and how even as highly advanced as it could be, might show no technosignature or SETI detectable signal, thus if all alien civilizations convert to a nanotechnological existence, then this would solve the Fermi Paradox.

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Updated 3 days ago.

What if the best Star Trek video game ever created is one that doesn’t have any graphics? That may sound crazy, but a recent Reddit user used GPT-4 to create an interactive text game based on Star Trek: The Next Generation. It’s the next best thing to using the holodeck for fans who just can’t wait for that next episode of Star Trek: Picard, and you can use their instructions to create your own awesome interactive adventure.

Consider humanity’s astounding progress in science during the past three hundred years. Now take a deep breath and project forward three billion years. Assuming humans survive, can we even conceive of what our progeny might be like? Will we colonize the galaxy, the universe?

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Nick Bostrom is a Swedish-born philosopher with a background in theoretical physics, computational neuroscience, logic, and artificial intelligence, as well as philosophy. He is the most-cited professional philosopher in the world under the age of 50.

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Abstract.

If all aspects of the mind-brain relationship were adequately explained by classical physics, then there would be no need to propose alternatives. But faced with possibly unresolvable puzzles like qualia and free will, other approaches are required. In alignment with a suggestion by Heisenberg in 1958, we propose a model whereby the world consists of two elements: Ontologically real Possibles that do not obey Aristotle’s law of the excluded middle, and ontologically real Actuals that do. Based on this view, which bears resemblance to von Neumann’s 1955 proposal (von Neumann, 1955), and more recently by Stapp and others (Stapp, 2007; Rosenblum and Kuttner, 2006), measurement that is registered by an observer’s mind converts Possibles into Actuals. This quantum-oriented approach raises the intriguing prospect that some aspects of mind may be quantum, and that mind may play an active role in the physical world. A body of empirical evidence supports these possibilities, strengthening our proposal that the mind-brain relationship may be partially quantum.

A new CRISPR tool corrected a genetic mutation that causes vision loss, in an experiment in mice — and its creators at the Wuhan University of Science and Technology (WUST) in China think it could be a safe way to treat countless other genetic diseases in people.

The challenge: Vision starts with light entering the eye and traveling to the retina. There, light-sensitive cells, called photoreceptors, convert light into electrical signals that are sent to the brain.

Retinitis pigmentosa is a rare — and, currently, incurable — genetic disease that can be caused by mutations in more than 100 different genes. These mutations destroy the cells of the retina, leading to vision loss, and for most people, there’s no way to stop the disease or reverse its damage (the exception is a gene therapy approved to treat mutations in the RPE65 gene).

A Paperclip Maximizer is an example of artificial intelligence run amok performing a job, potentially seeking to turn all the Universe into paperclips. But it’s also an example of a concept called Instrumental Convergence, where two entities with wildly different ultimate goals might end up acting very much alike. This concept is very important to preparing ourselves for future automation and machine minds, and we’ll explore that today.

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Credits:
The Paperclip Maximizer.
Episode 201a, Season 5 E36a.

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Neuroscientist Sergiu P. Pasca has made it his life’s work to understand how the human brain builds itself — and what makes it susceptible to disease. In a mind-blowing talk laden with breakthrough science, he shows how his team figured out how to grow “organoids” and what they call brain “assembloids” — self-organizing clumps of neural tissue derived from stem cells that have shown the ability to form circuits — and explains how these miniature parts of the nervous system are bringing us closer to demystifying the brain.

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Can you imagine if we had computer/brain interfaces what would happen? We’ll need brain firewalls and antivirus.


Android apps digitally signed by China’s third-biggest e-commerce company exploited a zero-day vulnerability that allowed them to surreptitiously take control of millions of end-user devices to steal personal data and install malicious apps, researchers from security firm Lookout have confirmed.

The malicious versions of the Pinduoduo app were available in third-party markets, which users in China and elsewhere rely on because the official Google Play market is off-limits or not easy to access. No malicious versions were found in Play or Apple’s App Store. Last Monday, TechCrunch reported that Pinduoduo was pulled from Play after Google discovered a malicious version of the app available elsewhere. TechCrunch reported the malicious apps available in third-party markets exploited several zero-days, vulnerabilities that are known or exploited before a vendor has a patch available.

Sophisticated attack

A preliminary analysis by Lookout found that at least two off-Play versions of Pinduoduo for Android exploited CVE-2023–20963, the tracking number for an Android vulnerability Google patched in updates that became available to end users two weeks ago. This privilege-escalation flaw, which was exploited prior to Google’s disclosure, allowed the app to perform operations with elevated privileges. The app used these privileges to download code from a developer-designated site and run it within a privileged environment.