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Advancing Geroscience & Gerotherapeutics — Dr. Nir Barzilai, MD, Albert Einstein College of Medicine.

Dr. Nir Barzilai, MD (https://www.einsteinmed.edu/faculty/484/nir-barzilai/) is the Director of the Institute for Aging Research at the Albert Einstein College of Medicine and the Director of the Paul F. Glenn Center for the Biology of Human Aging Research and of the National Institutes of Health’s (NIH) Nathan Shock Centers of Excellence in the Basic Biology of Aging. He is the Ingeborg and Ira Leon Rennert Chair of Aging Research, professor in the Departments of Medicine and Genetics, and member of the Diabetes Research Center and of the Divisions of Endocrinology & Diabetes and Geriatrics.

Dr. Barzilai’s research interests are in the biology and genetics of aging, with one focus of his team on the genetics of exceptional longevity, where they hypothesize and demonstrate that centenarians (those aged 100 and above) may have novel protective genes, which allow the delay of aging or for the protection against age-related diseases. The second focus of his work, for which Dr. Barzilai holds an NIH Merit award, is on the metabolic decline that occurs during aging, and his team hypothesizes that the brain leads this decline with some very interesting neuro-endocrine connections.

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Monica P. Medina (https://www.state.gov/biographies/monica-p-medina/) is Assistant Secretary for the Bureau of Oceans and International Environmental and Scientific Affairs at the U.S. Department of State. She was also recently appointed as United States Special Envoy for Biodiversity and Water Resources.

Previously, Secretary Medina was an adjunct professor at Georgetown University’s School of Foreign Service. She was also a Senior Associate on the Stephenson Ocean Security Project at the Center for Strategic and International Studies, and Co-Founder and Publisher of Our Daily Planet, an e-newsletter on conservation and the environment.

A former Principal Deputy Under Secretary of Commerce for Oceans and Atmosphere, Secretary Medina served as General Counsel of the National Oceanic and Atmospheric Administration (NOAA), and Special Assistant to the Secretary of Defense. Earlier in her career, Secretary Medina served as the Senior Counsel to former Senator Max Baucus on the Senate Environment and Public Works Committee, as the Senior Director for Ocean Policy at the National Geographic Society, as the ocean lead at the Walton Family Foundation, and in senior roles in other environmental organizations.

Secretary Medina attended college on an Army R.O.T.C. scholarship and began her career on active duty in the Army General Counsel’s Office. She received the Department of Defense Medal for Distinguished Public Service and the Army Meritorious Service Medal. She has a Bachelor’s degree in history from Georgetown University and a J.D. from Columbia Law School.

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Scientists have discovered a new layer of partly molten rock under the Earth’s crust that might help settle a long-standing debate about how tectonic plates move.

Researchers had previously identified patches of melt at a similar depth. But a new study led by The University of Texas at Austin revealed for the first time the layer’s global extent and its part in plate tectonics.

The research was published Feb. 6, 2023, in the journal Nature Geoscience.

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Architectures based on artificial neural networks (ANNs) have proved to be very helpful in research settings, as they can quickly analyze vast amounts of data and make accurate predictions. In 2020, Google’s British AI subsidiary DeepMind used a new ANN architecture dubbed the Fermionic neural network (FermiNet) to solve the Schrodinger equation for electrons in molecules, a central problem in the field of chemistry.

The Schroedinger is a partial differential equation based on well-established theory of energy conservation, which can be used to derive information about the behavior of electrons and solve problems related to the properties of matter. Using FermiNet, which is a conceptually simple method, DeepMind could solve this equation in the context of chemistry, attaining very accurate results that were comparable to those obtained using highly sophisticated quantum chemistry techniques.

Researchers at Imperial College London, DeepMind, Lancaster University, and University of Oxford recently adapted the FermiNet architecture to tackle a quantum physics problem. In their paper, published in Physical Review Letters, they specifically used FermiNet to calculate the ground states of periodic Hamiltonians and study the homogenous electron gas (HEG), a simplified quantum mechanical model of electrons interacting in solids.

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Over eighty years ago, Rabi oscillations were proposed to describe the strong coupling and population transfer in a two-level quantum system exposed to an oscillatory driving field. As compared to atoms, molecules have an extra degree of vibration, which adds an additional knob to the Rabi oscillations in light-molecule interactions. However, how such a laser-driven Rabi oscillation during the stretching of molecular bonds determines the kinetic energy release (KER) spectrum of dissociative fragments is still an open question.

In a new article published in Light: Science & Applications, a joint team of scientists, led by Professor Feng He from Shanghai Jiao Tong University and Professor Jian Wu from East China Normal University has investigated Rabi oscillations in a stretching molecule and discovered the strong-field-induced dissociation dynamics beyond the well-accepted resonant one-photon dissociation scenario. During the dissociation of the simplest molecular ion of H2+, coupled with the laser field, the electron hops between the 1sσg and 2pσu states, forming the Rabi oscillations.

The ionization-created nuclear wave packet (NWP) may propagate alternatively along the two potential energy curves towards a larger internuclear distance monotonically, termed as the rolling process, or may propagate outwards along the 2pσu curve followed by the inward propagation in the 1sσg curve and then be relaunched to 2pσu state again followed by subsequent dissociation, termed as the looping process. The rolling and looping dissociation pathways lead to different KERs of the ejected dissociative fragments, which have been verified by comparing experimental measurements with quantum simulation results.

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Arizona State University has officially begun a new chapter in X-ray science with a newly commissioned, first-of-its-kind instrument that will help scientists see deeper into matter and living things. The device, called the compact X-ray light source (CXLS), marked a major milestone in its operations as ASU scientists generated its first X-rays on the night of Feb. 2.

“This marks the beginning of a new era of science with compact accelerator-based X‑ray sources,” said Robert Kaindl, who directs ASU’s Compact X-ray Free Electron Laser (CXFEL) Labs at the Biodesign Institute and is a professor in the Department of Physics. “The CXLS provides hard X-ray pulses with high flux, stability and ultrashort durations, in a very compact footprint. This way, matter can be resolved at its fundamental scales in space and time, enabling new discoveries across many fields — from next-generation materials for computing and information science, to renewable energy, biomolecular dynamics, drug discovery and human health.”

Building the compact X-ray light source is the first phase of a larger CXFEL project, which aims to build two instruments including a coherent X-ray laser. As the first-stage instrument, the ASU CXLS generates a high-flux beam of hard X‑rays, with wavelengths short enough to resolve the atomic structure of complex molecules. Moreover, its output is pulsed at extremely short durations of a few hundred femtoseconds — well below a millionth of one millionth of a second — and thus short enough to directly track the motions of atoms.

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Researchers at Eötvös Loránd University have investigated whether the perception of time changes with age, and if so, how, and why we perceive the passage of time differently. Their study was published in Scientific Reports.

Time can play tricks on us. Many of us experienced the illusion that those long summers during childhood felt so much longer than the same 3 months feel like now as an adult. While we can argue why one summer may appear longer than the other and how the perception of time can compress and dilate durations depending on various factors, we can easily set up an experiment to gain more insights.

The researchers just did that. They asked how eventfulness affects our duration estimates when probing at different milestones during our cognitive development. They set aside three , 4–5, 9–10, and 18 years and older, and made them watch two videos, 1 minute each. The two videos were extracted from a popular animated series, balanced in visual and acoustic features, except for one feature: eventfulness.

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A study from researchers at The University of Texas MD Anderson Cancer Center, published today in Nature Cell Biology, details a previously unexplained type of cell death called disulfidptosis that could open the door for novel cancer therapeutic strategies.

As described in the study, disulfidptosis is triggered when cells with high levels of the SLC7A11 protein are subjected to glucose starvation. In preclinical models, treatment with glucose inhibitors induced disulfidptosis in cancer cells with high SLC7A11 expression, effectively suppressing without significant toxicity in normal tissues.

The study was led by Boyi Gan, Ph.D., and Junjie Chen, Ph.D., both professors of Experimental Radiation Oncology.

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