Main episode with Garry Nolan: https://youtu.be/g3bk1UXjKLIAs a listener of TOE you can get a special 20% off discount to The Economist and all it has to off…
Rao et al. found that lactylation stimulates the proteasomal degradation of cGAS independent of ubiquitin, which is compromised by phosphorylation of PSMA4 via disrupting its association with cGAS. Lactylation rewires PIK3CB activity and impairs ULK1-driven phosphorylation of PSMA4. Consequently, lactylation of cGAS sustains tumor growth and indicates the prognosis of LUAD.
Among the mountains of evidence that climate change is warming Earth faster than any other point in recorded history is the fact that most glaciers around the world are shrinking or disappearing. Melting glaciers and ice sheets are already the biggest contributors to global sea level rise, and according to the World Glacier Monitoring Service, ice loss rates have increased each decade since 1970. Yet, of the approximately 200,000 glaciers in the world currently, no database exists to identify which glaciers have disappeared, and when. The Global Land Ice Measurements from Space (GLIMS) initiative, an international project designed to monitor the world’s glaciers primarily using data from optical satellite instruments, aims to change that.
“Glaciers are indicators of climate change because they grow and shrink on longer timescales than rapidly changing weather, so they give a clearer signal about climate,” said Bruce Raup, a senior associate scientist at the National Snow and Ice Data Center (NSIDC) and director of the GLIMS initiative. “We know that glaciers are disappearing, but we’ve had no way to show that to people. So, we are making an effort to document glaciers that have disappeared and approximately when they disappeared.”
As the heyday of the creative economy boom becomes a distant memory, Stephen Armstrong looks at the generation who were once the high-rollers and are now facing an uncertain future as younger workers and AI come for their jobs, just as their children and parents are relying on them more than ever
James Kinross, a colon cancer surgeon, believes that changes in the gut microbiome are likely contributing to rising rates of the disease in young people.
Quantum computers have the potential to solve certain problems far more efficiently than classical computers. In a recent development, researchers have designed a quantum algorithm to simulate systems of coupled masses and springs, known as coupled oscillators. These systems are fundamental in modeling a wide range of physical phenomena, from molecules to mechanical structures like bridges.
To simulate these systems, the researchers first translated the behavior of the coupled oscillators into a form of the Schrödinger equation, which describes how the quantum state of a system evolves over time. They then used advanced Hamiltonian simulation techniques to model the system on a quantum computer.
Hamiltonian methods provide a framework for understanding how physical systems evolve, connecting principles of classical mechanics with those of quantum mechanics. By leveraging these techniques, the researchers were able to represent the dynamics of N coupled oscillators using only about log(N) quantum bits (qubits), a significant reduction compared to the resources required by classical simulations.
Nietzsche’s intuition about time’s nature likely emerged from his engagement with contemporary scientific thought, particularly the work of Johann Friedrich Herbart and Roger Joseph Boscovich, whose atomistic theories influenced Nietzsche’s conception of force and matter (Small, 2001). Additionally, Nietzsche’s reading of Heinrich Czolbe and Otto Caspari exposed him to cyclical cosmological theories that were precursors to modern conceptions of cosmological cycles.
More compelling than these historical influences, however, is the philosophical insight Nietzsche demonstrated in recognizing that a truly eternal cosmos with finite configurations must contain repetition. This insight, while not formulated in the mathematical language of relativity, nevertheless grasped a fundamental consequence of infinite time and finite states — one that would later be encoded in physical theory.
The convergence between Nietzsche’s eternal recurrence and modern physics becomes even more significant when we recognize similar conceptions in numerous cultural and religious traditions. This suggests a perennial human intuition about time’s nature that transcends historical and cultural boundaries.
A look inside Mindstate Design Labs’ effort to design drugs that reliably produce specific states of consciousness.