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Tyk2 Targeting in Immune-Mediated Inflammatory Diseases

The Janus kinase (Jak)/signal transducer and activating protein (STAT) pathways mediate the intracellular signaling of cytokines in a wide spectrum of cellular processes. They participate in physiologic and inflammatory cascades and have become a major focus of research, yielding novel therapies for immune-mediated inflammatory diseases (IMID). Genetic linkage has related dysfunction of Tyrosine kinase 2 (Tyk2)—the first member of the Jak family that was described—to protection from psoriasis. Furthermore, Tyk2 dysfunction has been related to IMID prevention, without increasing the risk of serious infections; thus, Tyk2 inhibition has been established as a promising therapeutic target, with multiple Tyk2 inhibitors under development.

What happened to those ‘little red dots’ Webb observed?

When the James Webb Space Telescope (JWST) began operations, one of its earliest surveys was of galaxies that existed during the very early universe. In December 2022, these observations revealed multiple objects that appeared as “little red dots” (LRDs), fueling speculation as to what they might be. While the current consensus is that these objects are compact, early galaxies, there is still debate over their composition and what makes them so red. On the one hand, there is the “stellar-only” hypothesis, which states that LRDs are red because they are packed with stars and dust.

This means that they could be similar to “dusty galaxies” that are observed in the universe today. On the other hand, there is the” MBH and galaxy” theory, which posits that LRDs are early examples of active galactic nuclei (AGNs) that exist throughout the universe in modern times. Each model has significant implications for how these galaxies subsequently evolved to become the types of galaxies observed more recently.

In a recent paper posted to the arXiv preprint server, an international team of astronomers considered the different scenarios. They concluded that LRDs began as “stellar only” galaxies that eventually formed the seeds of the supermassive black holes (SMBHs) at the center of galaxies today.

The Impact of Physicochemical Conditions on Lactic Acid Bacteria Survival in Food Products

Lactic acid bacteria (LAB), due to their many advantageous features, have been utilized in food manufacturing for centuries. Spontaneous fermentation, in which LAB play a fundamental role, is one of the oldest methods of food preservation. LAB survival and viability in various food products are of great importance. During technological processes, external physicochemical stressors appear often in combinations. To ensure the survival of LAB, adjustment of optimal physicochemical conditions should be considered. LAB strains should be carefully selected for particular food matrices and the technological processes involved. The LAB’s robustness to different environmental stressors includes different defense mechanisms against stress, including the phenomenon of adaptation, and cross-protection.

Blood test can detect more than 50 kinds of cancer, new study suggests

Made by U.S. pharmaceutical company Grail, the Galleri test aims to find fragments of DNA in a person’s blood that can indicate the presence of a cancerous tumor. Among the cancers that the test can detect, many have no current screening programs.

The PATHFINDER 2 study included more than 36,000 people aged 50 and older who had no cancer symptoms. In participants who were followed for more than a year, the test caught some 40.4% of cancer cases. For those who got a positive result on the Galleri test, 61.6% of them went on to be diagnosed with cancer—an improvement over previous trials of the test.

The results were presented on Saturday at the European Society for Medical Oncology meeting in Berlin, and have yet to be published in a peer-reviewed journal.

🌿 International Conference “Anti-Aging: Science and Practice of Healthy Longevity” —

October 21–22, 2025 (Online) 🌿

Dear colleagues and friends.

We are pleased to invite you to the International Scientific Conference “Anti-Aging: Science and Practice of Healthy Longevity”, organized by the Gerontology Section of the Moscow Society of Naturalists (MOIP) at Lomonosov Moscow State University, with the support of the Gerontology Society of the Ural Branch of the Russian Academy of Sciences (URAN).

📅 Dates: October 21–22, 2025 🕛 Time: 12:00–16:00 (Moscow time) 💻 Format: Online participation (free of charge) 🗣️ Working language: Russian.

🔹 October 21 — “Hypoxic Training (Therapy): Modern Aspects of Healthy Longevity Medicine” 🔹 October 22 — “Fundamental and Clinical Gerontology as the Basis of Healthy Longevity Medicine”

The conference will feature leading scientists from Russia, Germany, Belarus, Kyrgyzstan and other countries. Topics include: • Hypoxic therapy and adaptive mechanisms; • Geroprotection and the biology of aging; • Epigenetic reprogramming and cellular rejuvenation; • Applied aspects of active and healthy longevity.

🔗 Connection links: • Day 1 (October 21): https://my.mts-link.ru/j/38630705/5798697072

Continue reading “🌿 International Conference “Anti-Aging: Science and Practice of Healthy Longevity” —” | >

Cryosphere Chat ft. Emil Kendziorra — Tales from Biostasis 2025, Our Near Death Experiences

The gang catches up with Emil Kendziorra after the Biostasis 2025 conference at the European Biostasis Foundation. Watch it on YouTube here. Topics covered include:

• How to get a Tomorrow Bio ambulance in your hometown.
• Tomorrow Bio’s plan to collect brain samples to check ultra-structure preservation in its cryonics patients — and how it will respond to what it finds.
• What’s new and what’s next for Tomorrow Bio.
• Our near death experiences.

Links:
• Cryosphere Discord Server: / discord.
• Cryonics Subreddit: / cryonics.

Scientists create a metal that does not break, rust, or melt

A new alloy made from chromium, molybdenum, and silicon – three metals known for strength, heat tolerance, and stability – breaks expectations by staying tough at room temperature while resisting oxidation even under extreme heat.

The study reports room temperature ductility, oxidation resistance in air to 1,100 C, and a melting point near 2,000 C.

A Tiny Peptide Can Freeze Parkinson’s Proteins Before They Turn Toxic

As Parkinson’s disease progresses, harmful protein clumps build up in the brain, blocking communications between neurons and killing them off – but what if we could prevent these clusters from forming?

Researchers led by a team from the University of Bath in the UK have achieved just that in a basic worm model of Parkinson’s. They engineered a peptide, a small amino acid chain, to essentially keep a protein called alpha-synuclein locked in its healthy shape. This prevented the misfolding that leads to clumps.

The potential treatment checks several important boxes: it’s durable, and it can survive inside cells without causing any toxic side effects.

NVIDIA Embraces the ‘Made in USA’ Narrative, As Jensen Huang Unveils the First Blackwell Chip Wafer Produced by TSMC Arizona

NVIDIA’s CEO has revealed that TSMC has produced the first Blackwell chip wafer in America, a massive development towards the future of manufacturing in the nation.

Since the Trump administration took office, efforts to bring manufacturing back to the US have influenced almost every tech giant, with NVIDIA leading the way. The firm announced plans to invest $500 billion in American manufacturing, prompting suppliers like Foxconn and Quanta to set up manufacturing facilities in the US. In a blog post shared by Team Green, it is revealed that TSMC Arizona has begun manufacturing Blackwell on American soil, and Jensen Huang himself paid a visit to Phoenix to celebrate this massive achievement.

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