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Human CLOCK gene enhances brain connectivity and mental flexibility in mice, study finds

Clock genes are a set of genes known to contribute to the regulation of the human body’s internal 24-hour cycle, also known as the circadian rhythm. One of these genes is the so-called CLOCK gene, a protein that regulates the activity of other genes, contributing to recurrent patterns of sleep and wakefulness.

Past findings suggest that this gene is also expressed in the neocortex, a brain region that supports important cognitive abilities, including reasoning, decision-making and the processing of language. However, the gene’s possible contribution to these specific brain functions remains poorly understood.

Researchers at UT Southwestern Medical Center recently carried out a study on genetically modified mice aimed at better understanding how the expression of the CLOCK gene in the human neocortex influences cognitive functions. Their findings, published in Nature Neuroscience, suggest that the gene plays a role in the formation of connections between neurons, which in turn influence mental and behavioral flexibility.

When does the body really start aging? The answer may surprise you

When does aging really shift into overdrive? A new study suggests it may be sooner than you think.

Scientists at the Chinese Academy of Sciences studied proteins in tissue taken from about 70 people ages 14 to 68, according to the study published July 25 in the journal Cell.

These proteins give scientists a window of when the aging process may begin on a cellular level, said Dr. Thomas Blackwell, associate dean for graduate medical education and professor of medicine at the University of Texas Medical Branch.

New research unveils vast influence of B vitamins on health and disease

Eight essential nutrients make up the suite of B vitamins also known as the B complex. Researchers from Tufts University and elsewhere have revealed that these B vitamins influence a vast spectrum of human health and disease, including cognitive function, cardiovascular health, gastric bypass recovery, neural tube defects, and even cancer.

“It’s hard to study the B vitamins in isolation,” says gastroenterologist Joel Mason, senior scientist at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) and professor at the Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy and Tufts University School of Medicine. “Four of these B-vitamins cooperate as co-factors in many critical activities in cells in what we call ‘one carbon metabolism’.”

One carbon metabolism is a series of pathways that allow for the transfer of single-carbon units to cells for essential processes such as DNA synthesis, amino acid metabolism, and more. It’s their role in all these crucial biological functions that make the B vitamins so important-and so challenging to tease out how they contribute positively and, perhaps negatively, to human health.

Solving a 13-Billion-Year-Old Mystery: Scientists Recreate the Universe’s First Chemical Reaction

Researchers have uncovered new insights into the reaction pathways of the universe’s first molecule. Shortly after the Big Bang, which took place around 13.8 billion years ago, the universe was a seething, dense expanse of extreme heat. In just a matter of seconds, it began to cool enough for the f

MIT engineers uncover a surprising reason why tissues are flexible or rigid

Water makes up around 60 percent of the human body. More than half of this water sloshes around inside the cells that make up organs and tissues. Much of the remaining water flows in the nooks and crannies between cells, much like seawater between grains of sand.

Now, MIT engineers have found that this “intercellular” fluid plays a major role in how tissues respond when squeezed, pressed, or physically deformed. Their findings could help scientists understand how cells, tissues, and organs physically adapt to conditions such as aging, cancer, diabetes, and certain neuromuscular diseases.

In a paper appearing today in Nature Physics, the researchers show that when a tissue is pressed or squeezed, it is more compliant and relaxes more quickly when the fluid between its cells flows easily. When the cells are packed together and there is less room for intercellular flow, the tissue as a whole is stiffer and resists being pressed or squeezed.

Sweeping survey maps hundreds of satellite systems orbiting dwarf galaxies

We usually think of satellites as small objects orbiting planets or stars. But in the broader universe, galaxies themselves can have satellites—smaller galaxies bound by gravity that orbit a larger host, carrying with them stars, gas, dust, and dark matter.

Most of what we know about satellite galaxies comes from studying the Milky Way and other similarly large galaxies. But a new study led by Dartmouth astronomers broadens that understanding by exploring the satellites of dwarf galaxies—systems less than a tenth the size of the Milky Way.

The multi-institutional survey triples the number of dwarf galaxies surveyed for satellites, the researchers report in The Astrophysical Journal. The study identifies 355 candidate satellite galaxies, including 264 that were previously undocumented. The researchers suggest that 134 of these candidates are highly likely to be satellite galaxies.

New carbon material sharpens proton beams, potentially boosting cancer treatment precision

Researchers from the National University of Singapore (NUS) have developed a groundbreaking carbon membrane that could revolutionise proton therapy for cancer patients, and advance technologies in medicine and other areas such as energy devices and flexible electronics.

The new carbon material which is just a single atom thick shows incredible promise in enabling high-precision proton beams. Such beams are key to safer and more accurate proton therapy for cancer treatment. The new material, called the ultra-clean monolayer amorphous carbon (UC-MAC), could outperform best in class materials like graphene or commercial carbon films.

The research was led by Associate Professor Lu Jiong and his team from the NUS Department of Chemistry, in collaboration with international partners.

New Technique Uses Focused Sound Waves and Holograms to Control Brain Circuits

NEW YORK, Aug. 5, 2025 /PRNewswire/ — A new study provides the first visual evidence showing that brain circuits in living animals can be activated by ultrasound waves projected into specific patterns (holograms).

Led by scientists at NYU Langone Health and at the University of Zurich and ETH Zurich in Switzerland, the study describes a system that combines sources of ultrasound waves and a fiber scope connected to a camera to visualize in study mice brain targets that are directly activated by the sound. This lays the groundwork, the study authors say, for a new way to treat neurological diseases and mental health disorders from outside of the body.

Already, there are applications approved by the Food and Drug Administration and designed to reduce tremor symptoms seen in Parkinson’s disease, using intense sound waves to kill brain cells called neurons within neural pathways linked to tremors. Rather than kill neurons, the lower-intensity ultrasound waves used in the current work can temporarily activate them, the researchers say. The resulting effects can be widespread as neurons relay messages to other neurons within their circuits and between interconnected neuronal circuits.

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