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Blog – Page 39

Ubiquitin marks proteins for degradation, whereby ubiquitin molecules can be combined in different types and numbers forming different chains. Researchers at the Max Planck Institute of Biochemistry (MPIB) have developed the new UbiREAD technology to decode the various combinations of ubiquitin molecules—the ubiquitin code—which determine how proteins are degraded in cells.

Using UbiREAD, scientists label with specific codes and track their degradation in cells. The study, published in Molecular Cell, revealed which ubiquitin code can or cannot induce intracellular protein degradation.

Proteins are the building blocks of life, maintaining cellular structure and function. However, when proteins become damaged, misfolded, or obsolete, they can lead to a range of diseases, from Alzheimer’s and Parkinson’s to cancer and muscular dystrophy. To prevent this, cells have developed a sophisticated system to mark unwanted proteins for degradation with a small protein called ubiquitin.

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A team of computer scientists and financial specialists at University College London has developed a tool to track the coordination efforts of pump-and-dump crypto coin scheme manipulators. They have published a paper on the arXiv preprint server describing their tool called Perseus, its purpose and how it works.

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The success of in vitro fertilization depends on many factors, one of which is sperm viability. A recent study from the University of Illinois Urbana-Champaign documents a new way to select viable sperm and prolong their viability in the laboratory, reducing one source of variability during the process. The work is published in the journal Scientific Reports.

“The in women, or the oviduct, has an ability to lengthen sperm lifespan that, until now, we couldn’t recreate in IVF. In 2020, we discovered that complex sugars called glycans are the components of the oviduct that can bind and store sperm and keep them alive,” said senior study author David Miller, professor in the Department of Animal Sciences, part of the College of Agricultural, Consumer and Environmental Sciences at Illinois.

Miller’s group collaborated with chemists to test hundreds of oviduct glycans for their ability to bind pig sperm, settling on one called sulfated Lewis X trisaccharide, or suLeX, for further testing. They focused on pig sperm not only as a proof of concept for future human studies, but also because animal agriculture relies on IVF, too. In pig IVF, multiple sperm often fertilize single eggs, resulting in inviable embryos. The hope with using glycans was that fewer free-swimming sperm would approach and fertilize eggs simultaneously.

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Scholars at the School of Engineering of the Hong Kong University of Science and Technology (HKUST) have unveiled an innovation that brings artificial intelligence (AI) closer to quantum computing—both physically and technologically.

Led by Prof. Shao Qiming, Assistant Professor at the Department of Electronic and Computer Engineering, the research team has developed a new computing scheme that works at extremely low temperatures. As a critical advancement in quantum computing, it can significantly reduce latency between artificial intelligence (AI) agents and quantum processors while boosting energy efficiency. The solution was made possible by utilizing a special technology known as magnetic topological insulator Hall-bar devices.

This latest invention addresses a major challenge concerning the operational environment and hardware requirements of quantum computers, amid growing interest in the amalgamation of quantum computing—widely seen as the future of high-speed and high-efficiency computing, with artificial intelligence—a fast-evolving technology.

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Pedestrian crossings generally showcase the best in pedestrian behavior, with people naturally forming orderly lanes as they cross the road, smoothly passing those coming from the opposite direction without any bumps or scrapes. Sometimes, however, the flow gets chaotic, with individuals weaving through the crowd on their own haphazard paths to the other side.

Now, an international team of mathematicians, co-led by Professor Tim Rogers at the University of Bath in the UK and Dr. Karol Bacik at MIT in the US has made an important breakthrough in their understanding of what causes human flows to disintegrate into tangles. This discovery has the potential to help planners design road crossings and other pedestrian spaces that minimize chaos and enhance safety and efficiency.

In a paper appearing in the journal Proceedings of the National Academy of Sciences, the team pinned down the precise point at which crowds of pedestrians crossing a road collapse from order to disorder.

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Many systems in nature—and in society—can suddenly change their properties: Water freezes at normal pressure at 32°F, a power grid collapses when a central substation fails, or a society splits into opposing factions following a major event. All of these processes are examples of so-called phase transitions—tipping points where a system abruptly shifts into a new state.

“Often, we can predict these transitions easily. We know at what temperature water freezes. But sometimes, it is extremely difficult to foresee when and how these changes will occur,” explains CSH researcher Jan Korbel, one of the authors of the study, which was published in Nature Communications.

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Terahertz (THz) waves are located between microwaves and infrared light in the electromagnetic spectrum. They can pass through many materials without causing damage, making them useful for security scanning, medical imaging, and high-speed wireless communication. Unlike visible light or radio waves, THz waves can reveal structural details of biological molecules and penetrate nonmetallic objects like clothing and paper.

THz waves hold great promise, but to harness them effectively, their polarization (the direction in which the waves vibrate) must be controlled. Polarization control is crucial for optimizing THz applications, from enhancing to improving imaging and sensing.

Unfortunately, existing THz polarization control methods rely on bulky external components like wave plates or metamaterials. These solutions are often inefficient, limited to narrow frequency ranges, and unsuitable for compact devices. To overcome these limitations, researchers have been exploring approaches to control THz polarization directly at the source.

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Researchers at QuTech, in collaboration with Fujitsu and Element Six, have demonstrated a complete set of quantum gates with error probabilities below 0.1%. While many challenges remain, being able to perform basic gate operations with errors occurring below this threshold, satisfies an important condition for future large-scale quantum computation. The research was published in Physical Review Applied on 21 March 2025.

Quantum computers are anticipated to be able to solve important problems that are beyond the capabilities of classical computers. Quantum computations are performed through a large sequence of basic operations, called .

For a quantum computer to function, it is essential that all quantum gates are highly precise. The probability of an error during the gates must be below a threshold, typically of the order 0.1 to 1%. Only then, errors are rare enough for error correction methods to work successfully and ensure reliable with noisy components.

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When University of Texas at Dallas researchers tested a new surface that they designed to collect and remove condensates rapidly, the results surprised them. The mechanical engineers’ design collected more condensates, or liquid formed by condensation, than they had predicted based on a classic physics model.

The finding revealed a limitation in the existing model and inspired the researchers to develop a new theory to explain the phenomenon, which they outline in an article published online March 13 in the journal Newton.

The theory is critical to the researchers’ work to develop innovative surfaces for applications such as harvesting water from air without electricity.

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An Aston University researcher has conducted the first experimental demonstration of intricate and previously theorized behaviors in the fundamental patterns that govern oscillatory systems in nature and technology.

Synchronization regions, also known as Arnold’s tongues because of the shape they take when shown on a graph, help scientists understand when things will stay in sync and when they won’t.

Arnold’s tongues are observed in a large variety of natural phenomena that involve oscillating quantities, such as heartbeats, pendulum swings or flashing lights.

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