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Blog – Page 396

A new quantum algorithm developed by University of Georgia statisticians addresses one of the most complex challenges in single-cell analysis, signaling significant impact in both the fields of computational biology and quantum computing.

The study, “Bisection Grover’s Search Algorithm and Its Application in Analyzing CITE-seq Data,” was published in the Journal of the American Statistical Association on Sept. 20.

While traditional approaches struggle to handle the immense amount of data generated from measuring both RNA and in individual cells, the new enables analysis of data from a single-cell technology known as CITE-seq. It allows for selection of the most important markers from billions of possible combinations—a task that would be formidable using classical methods.

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#brainstimulation #brainfunction #deepbrainstimulation #memory #magneticstimulation #centralnervoussystem #agerelatedmemorydecline

Advances in Neurostimulation in Aging: From Basic Science to Clinical Applications

Guest Editors Dr. Orestis Stylianou and Dr. Gianluca Susi and Associate Editors Dr. Peter Mukli and Dr. Frigyes Samuel Racz and the editorial team of GeroScience (Official Journal of the American Aging Association, published by Springer) invite submission of original research articles and review articles related to basic and clinical research focused on neurostimulation in aging.

Over the past two decades, studies have shown the potential benefits of invasive and non-invasive brain stimulation techniques in addressing age-related alterations in brain function. While invasive techniques were previously dominant in small-scale clinical investigations, recent advances have significantly reduced the invasiveness of these techniques, making them safer and more accessible for research and medical applications. Transcranial current and magnetic stimulation (tCS and tMS) as well as deep brain stimulation (DBS) have shown promising results in improving various types of memory in the elderly population, including but not limited to working, episodic, associative, semantic, and procedural memory. These interventions have the potential to play a vital role in enhancing healthy brain aging and treating age-related pathological conditions affecting the central nervous system.

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We’ve all experienced the moment of panic when a glass slips from our hands, shattering into pieces upon hitting the ground. What if this common mishap could become a thing of the past?

Now, a new discovery by researchers at Tohoku University has offered insights into how resists breakage, potentially paving the way for highly durable, break-resistant materials. The breakthrough has wide ranging implications for glass-related industries.

Details of their findings are published in the journal Acta Materialia.

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A novel breakthrough, leveraging CRISPR gene-editing technology, is revolutionizing how scientists study sEVs. This innovative approach, known as CIBER (CRISPR-assisted individually barcoded sEV-based release regulator), enables researchers to investigate thousands of genes simultaneously.

By tagging sEVs with unique RNA “barcodes,” CIBER offers unparalleled insights into the molecular processes regulating sEV release, setting the stage for advancements in biotechnology and disease treatment.

Extracellular vesicles, which include sEVs, are small, membrane-enclosed particles released by cells into their surroundings. Their size, origin, and cargo determine their classification. sEVs, typically 30–200 nanometers in diameter, are among the smallest but most intriguing members of this group. These vesicles transport biomolecules—such as RNA, proteins, and lipids —between cells, acting as communication messengers.

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