The hallmark of a good AI model is its ability to work the same in different groups, settings, and situations. See how these NCI researchers used in-house and external images to test their prostate model’s generalizability.
How do human organs develop and what happens to them when they become diseased? To answer these questions, researchers are increasingly focusing on so-called organoids. These mini-organs, just a few millimeters in size, consist of groups of cells cultivated in the laboratory that can form organ-like structures.
Similar to embryonic development, organoids make it possible to investigate the interaction of cells in three-dimensional space—for example in metabolic processes or disease mechanisms.
The production of organoids is tricky; the required nutrients, growth factors and signaling molecules must be added in a specific order and at specific times according to a precise schedule.
Scientists have found a new link between diet and colon cancer risk that could change how we fight the disease with more targeted treatments.
Ultimately, the goal is to find ways to stop deadly disease caused by Cryptococcus neoformans from developing in humans and animals. But until that time, finding new and better ways to treat already existent disease and its symptoms is a high priority.
The laboratory of Kirsten Nielsen in the Center for One Health Research has taken a step toward improved treatment of Cryptococcus, completing a six-year study to examine the virulence of 38 clinical isolates from various strains of Cryptococcus. The results are published in Nature Communications.
“The question that we’ve been addressing is: Can we predict severe disease outcomes in patients?” said Nielsen, professor of microbiology and immunology in the Virginia-Maryland College of Veterinary Medicine. “If we can predict disease outcome, then we can treat patients better. In these studies, we identified not just the genes that allow Cryptococcus to cause disease, but also the gene alleles that allow it to cause more disease or less disease.”
Distance, Mass, and Advanced Observations
To refine the measurements of Cygnus X-1, astronomers used parallax—a technique that calculates stellar distances based on their apparent motion against the backdrop of distant stars as Earth orbits the Sun. Using the Very Long Baseline Array (VLBA), a network of 10 radio telescopes across the United States, researchers tracked the system’s full orbit over six days. They determined that the black hole lies about 7,200 light-years from Earth, significantly farther than the previous estimate of 6,000 light-years.
This updated distance means its blue supergiant companion star is also more massive and brighter than expected, with a mass 40 times that of the Sun. Combined with the black hole’s orbital period, these findings provided the recalculated mass of Cygnus X-1’s black hole.
For the first time, scientists have observed a collection of particles, also known as a quasiparticle, that’s massless when moving one direction but has mass in the other direction. The quasiparticle, called a semi-Dirac fermion, was first theorized 16 years ago, but was only recently spotted inside a crystal of semi-metal material called ZrSiS. The observation of the quasiparticle opens the door to future advances in a range of emerging technologies from batteries to sensors, according to the researchers.
The team, led by scientists at Penn State and Columbia University, recently published their discovery in the journal Physical Review X.
“This was totally unexpected,” said Yinming Shao, assistant professor of physics at Penn State and lead author on the paper. “We weren’t even looking for a semi-Dirac fermion when we started working with this material, but we were seeing signatures we didn’t understand—and it turns out we had made the first observation of these wild quasiparticles that sometimes move like they have mass and sometimes move like they have none.”
Cyanobacteria use an AM radio-like principle to coordinate cell division with circadian rhythms, encoding information through pulse amplitude modulation.
Cyanobacteria, an ancient group of photosynthetic bacteria, have been discovered to regulate their genes using the same physics principle used in AM radio transmission.
New research published in Current Biology has found that cyanobacteria use variations in the amplitude (strength) of a pulse to convey information in single cells. The finding sheds light on how biological rhythms work together to regulate cellular processes.
Precious few garments have been made of spider silk. In 2012, a cape and shawl made from natural spider silk were displayed at the Victoria and Albert Museum, where visitors learned that the garments were the result of a unique project that spanned eight years and involved the harvesting of silk from 1.2 million spiders. In 2019, a rather less painstaking project utilized fibroin, the protein found in natural spider silk, to fabricate an outerwear jacket, North Face’s Moon Parka. Starting with fibroin meant that silk could be sourced from genetically modified bacteria, which are easier to work with than spiders. Nonetheless, the Moon Parka, which takes its name from the word moonshot, was never meant to be mass produced. It was available by lottery for just a limited time.
Museum pieces and moonshots are hardly synonymous with “mass production.” Is there another way to generate spider silk–based textiles, one that has more commercial potential? Yes, according to Kraig Biocraft Laboratories, which uses transgenic silkworms to produce lines of recombinant spider silk. The company plans to produce up to 10 metric tons of spider silk in 2025. Production of actual spider silk lines on this scale would allow textile manufacturers to test the silk on their own equipment.
It’s not just textiles that may benefit. Recombinant spider silk’s tensile strength, weight, and durability make it attractive for myriad applications, including tissue scaffolds and sutures in the biomedical field, as well as textiles and ballistic materials.