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Study reveals ‘switch-like’ behavior for hundreds of genes with links to human disease

Gene expression, where cells use the genetic information encoded in DNA to produce proteins, has been thought of as a dimmer light.

How much a particular gene gets expressed continually rises and falls, depending on the needs of a cell at any given time. It’s like adjusting the lighting of a room until it’s just right for your mood.

But University at Buffalo researchers have shown that a considerable portion of a human’s roughly 20,000 genes express more like your standard light switch—fully on or fully off.

A.I. Can Already See You in Ways You Can’t See Yourself

Not only can A.I. now make these assessments with remarkable, humanlike accuracy; it can make millions of them in an instant. A.I.’s superpower is its ability to recognize and interpret patterns: to sift through raw data and, by comparing it across vast data sets, to spot trends, relationships and irregularities.

As humans, we constantly generate patterns: in the sequence of our genes, the beating of our hearts, the repetitive motion of our muscles and joints. Everything about us, from the cellular level to the way our bodies move through space, is a source of grist for A.I. to mine. And so it’s no surprise that, as the power of the technology has grown, some of its most startling new abilities lie in its perception of us: our physical forms, our behavior and even our psyches.

Scientists discover a materials maze that prevents bacterial infections

Scientists at the University of Nottingham have discovered surface patterns that can drastically reduce bacteria’s ability to multiply on plastics, which means that infections on medical devices, such as catheters, could be prevented.

The findings of the study, which are published in Nature Communications, show that when bacterial cells encounter patterned grooves on a surface, they lose their ability to form biofilms.

Biofilms are surface-associated slime-cities which help protect the bacteria from the body’s natural defenses against . This, in turn, means the infection is effectively prevented before it can become fully established and would also positively activate the immune system to get rid of any individual bacteria that were there.

World’s First Hybrid Betavoltaic Cell Promises Decades of Power Without Charging

Scientists have achieved a major breakthrough by creating the world’s first next-generation betavoltaic cell. This advanced power source was made by directly connecting a radioactive isotope electrode to a perovskite absorber layer, a cutting-edge material known for its efficiency.

To boost performance, the team embedded carbon-14-based quantum dots into the electrode and improved the structure of the perovskite layer. These innovations led to a highly stable power output and impressive energy conversion efficiency.

The findings were published in the journal Chemical Communications and led by Professor Su-Il In of the Department of Energy Science & Engineering at DGIST (President Kunwoo Lee).

How can we tell if AI is lying? New method tests whether AI explanations are truthful

Given the recent explosion of large language models (LLMs) that can make convincingly human-like statements, it makes sense that there’s been a deepened focus on developing the models to be able to explain how they make decisions. But how can we be sure that what they’re saying is the truth?

In a new paper, researchers from Microsoft and MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) propose a novel method for measuring LLM explanations with respect to their “faithfulness”—that is, how accurately an explanation represents the reasoning process behind the model’s answer.

As lead author and Ph.D. student Katie Matton explains, faithfulness is no minor concern: if an LLM produces explanations that are plausible but unfaithful, users might develop false confidence in its responses and fail to recognize when recommendations are misaligned with their own values, like avoiding bias in hiring.

Excessive oleic acid, found in olive oil, shown to drive fat cell growth

Eating a high-fat diet containing a large amount of oleic acid—a type of fatty acid commonly found in olive oil—could drive obesity more than other types of dietary fats, according to a study published in the journal Cell Reports.

The study found that oleic acid, a monounsaturated fat associated with obesity, causes the body to make more fat cells. By boosting a signaling protein called AKT2 and reducing the activity of a regulating protein called LXR, high levels of oleic acid resulted in faster growth of the precursor cells that form new fat cells.

“We know that the types of fat that people eat have changed during the obesity epidemic. We wanted to know whether simply overeating a diet rich in fat causes obesity, or whether the composition of these fatty acids that make up the oils in the diet is important. Do specific fat molecules trigger responses in the cells?” said Michael Rudolph, Ph.D., assistant professor of biochemistry and physiology at the University of Oklahoma College of Medicine and member of OU Health Harold Hamm Diabetes Center.

Nanofibers yield stronger, tougher carbon fiber composites

Researchers at the U.S. Department of Energy (DOE)’s Oak Ridge National Laboratory (ORNL) have developed an innovative new technique using carbon nanofibers to enhance binding in carbon fiber and other fiber-reinforced polymer composites—an advance likely to improve structural materials for automobiles, airplanes and other applications that require lightweight and strong materials.

The results, published in the journal Advanced Functional Materials, show promise for making products that are stronger and more affordable, opening new options for U.S. manufacturers to use in applications such as energy and national security.

“The challenge of improving adhesion between carbon fibers and the that surrounds them has been a concern in industry for some time, and a lot of research has gone into different approaches,” said Sumit Gupta, the ORNL researcher who led the project. “What we found is that a hybrid technique using to create chemical and mechanical bonding yields excellent results.”

DNA ‘glue’ could help prevent and treat diseases triggered by ageing

Macquarie University researchers have discovered a naturally occurring protein found in human cells plays a powerful role in repairing damaged DNA — the molecule that carries the genetic instructions for building and maintaining living things.

The discovery, published in the journal Ageing Cell, could hold the key to developing therapies for devastating age-related diseases such as motor neuron disease (MND), Alzheimer’s disease, and Parkinson’s disease.

Hope: Dr Sina Shadfar, pictured, and colleagues discovered a protein which they have shown for the first time acts like a ‘glue’, helping to repair broken DNA, which is widely accepted as one of the main contributors to ageing and the progression of age-related diseases.

The research, conducted by neurobiologist Dr Sina Shadfar and colleagues in the Motor Neuron Disease Research Centre, reveals a protein called protein disulphide isomerase (PDI) helps repair serious deoxyribonucleic acid (DNA) damage. This breakthrough opens new possibilities for therapies aimed at boosting the body’s ability to fix its own DNA — a process that becomes less efficient as we age.