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A research team led by Prof. Xue Yuanchao from the Institute of Biophysics of the Chinese Academy of Sciences has developed a new method for global profiling of in-situ RNA–RNA contacts associated with a specific RNA-binding protein (RBP) and revealed positional mechanisms by which PTBP1-associated RNA loops regulate cassette exon splicing.

This study was published online in Molecular Cell on March 22.

In , the same pre-mRNA can produce multiple protein isoforms to execute similar or different biological functions through . Several longstanding models proposed that RBPs may regulate alternative splicing by modulating long-range RNA–RNA interactions (RRI). However, direct experimental evidence was lacking.

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The secret to a perfect croissant is the layers—as many as possible, each one interspersed with butter. Similarly, a new material with promise for new applications is made of many extremely thin layers of metal, between which scientists can slip different ions for various purposes. This makes them potentially very useful for future high-tech electronics or energy storage.

Until recently, these materials—known as MXenes, pronounced “max-eens”—were as labor-intensive as good croissants made in a French bakery.

But a new breakthrough by scientists with the University of Chicago shows how to make these MXenes far more quickly and easily, with fewer toxic byproducts.

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The “iPhone moment for A.I.” hype takes many hues, but Nvidia is about the future of computing itself. NVIDIA DGX supercomputers, originally used as an AI research instrument, are now running 24/7 at businesses across the world to refine data and process AI.

While OpenAI gets a lot of the glory, I believe the credit should go to Nvidia. Launched late last year, ChatGPT went mainstream almost instantaneously, attracting over 100 million users, making it the fastest-growing application in history. “We are at the iPhone moment of AI,” Huang said. Nvidia makes about $6 to $7 Billion a fiscal quarter in revenue.

Nvidia said it’s offering a new set of cloud services that will allow businesses to create and use their own AI models based on their proprietary data and specific needs. The new services, called Nvidia AI Foundations, include three major components and are meant to accelerate enterprise adoption of generative AI: Enterprises can use Nvidia NeMo language service or Nvidia Picasso image, video and 3D service to gain access to foundation models that can generate text or images based on user inputs.

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In a ground-breaking experiment, scientists have successfully created the fifth form of matter, known as the Bose-Einstein condensate (BEC), for a remarkable duration of six minutes.

This major accomplishment has the potential to revolutionize our understanding of quantum mechanics and open the door to new technological advancements. In this article, we will explore the significance of this achievement, the nature of BECs, and the potential applications of this newfound knowledge.

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Scientists had a hard time reconstructing how complex molecular parts are being held together. However, that was before SISSA’s Cristian Micheletti and his team studied how the DNA double helix unzips when translocated at high velocity through a nanopore.

DNA Double Helix’s Unzipping

DNA has a double helix structure because it consists of two spiral chains of deoxyribonucleic acid. Its shape is reminiscent of a spiral staircase.

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Our brains aren’t limited to producing just one type of brain wave at a time, but usually, one type is dominant, and the type it is can often be linked to your level of alertness: delta waves may dominate when you sleep, while gamma waves might dominate when you concentrate intensely.

The idea: Researchers have previously observed that people with Alzheimer’s — a devastating neurological disease affecting more than 6 million people in the US alone — may have weaker and less in-sync gamma waves than people who don’t have the disease.

In a series of past studies, MIT researchers demonstrated a deceptively simple way to increase the power and synchronization of these waves in mouse models of Alzheimer’s: expose the animals to lights flickering and/or sounds clicking at a frequency of 40 Hz.

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Organoids are an incredible tool for research into the brain. Cerebral organoids are created by growing human stem cells in a bioreactor. They might be the key to unlocking the answers to many of our questions about the brain. We explain how they’re made and some of the discoveries they’ve helped with so far!
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