The TRACERx project reports data from studies tracking human lung cancer.
Researchers have recently made a groundbreaking discovery in the field of kidney disease. They have found a new pathway that could potentially prevent kidney failure in thousands of people. Dr. Carl May and his team at Bristol Medical School, with funding from Kidney Research UK, have discovered a new treatment pathway for non-genetic nephrotic syndrome.
This targets the unknown factor that leads to kidney failure. Nephrotic syndrome is a rare kidney condition that causes protein to leak into the urine, affecting around 10,000 people annually in the UK. The discovery offers hope for patients, especially children, who may develop kidney failure.
Researchers from Bristol Renal have identified a receptor called PAR-1 that works in conjunction with an unknown factor to cause kidney failure in patients with idiopathic nephrotic syndrome (INS). They found that anti-PAR-1 treatments could block the effect of the factor and prevent kidneys from failing, potentially making transplantation a more viable option for more patients.
Beyond our own Milky Way galaxy, there are physical limits on our access to the Universe. In this new video from PBS Space Time, we explore the absolute limit of our future view of the Universe, and of the Universe’s ability to influence us.
We humans have always been explorers. The great civilisations that have arisen across the world are owed to our restless ancestors. These days, there’s not much of Earth left to explore. But if we look up, there’s a whole Universe out there waiting for us. Future generations may one day explore the cosmos and could even settle entire other galaxies.
However, there is a fundamental limit to how much of the Universe we can expand into. So, just how big could humanity get? Matt O’Dowd, astrophysicist and host of PBS Space Time, looks at the obstacles that our descendants could face in the very distant future.
Reversing schizophrenia with gene therapy year 2023.
Copy-number variations in the ARHGAP10 gene encoding Rho GTPase–activating protein 10 are associated with schizophrenia. Model mice (Arhgap10 S490P/NHEJ mice) that carry “double-hit” mutations in the Arhgap10 gene mimic the schizophrenia in a Japanese patient, exhibiting altered spine density, methamphetamine-induced cognitive dysfunction, and activation of RhoA/Rho-kinase signaling. However, it remains unclear whether the activation of RhoA/Rho-kinase signaling due to schizophrenia-associated Arhgap10 mutations causes the phenotypes of these model mice. Here, we investigated the effects of fasudil, a brain permeable Rho-kinase inhibitor, on altered spine density in the medial prefrontal cortex (mPFC) and on methamphetamine-induced cognitive impairment in a touchscreen‑based visual discrimination task in Arhgap10 S490P/NHEJ mice. Fasudil (20 mg/kg, intraperitoneal) suppressed the increased phosphorylation of myosin phosphatase–targeting subunit 1, a substrate of Rho-kinase, in the striatum and mPFC of Arhgap10 S490P/NHEJ mice. In addition, daily oral administration of fasudil (20 mg/kg/day) for 7 days ameliorated the reduced spine density of layer 2/3 pyramidal neurons in the mPFC. Moreover, fasudil (3–20 mg/kg, intraperitoneal) rescued the methamphetamine (0.3 mg/kg)-induced cognitive impairment of visual discrimination in Arhgap10 S490P/NHEJ mice. Our results suggest that Rho-kinase plays significant roles in the neuropathological changes in spine morphology and in the vulnerability of cognition to methamphetamine in mice with schizophrenia-associated Arhgap10 mutations.
face_with_colon_three year 2022.
For the first time, scientists have created a quantum computing experiment for studying the dynamics of wormholes – that is, shortcuts through spacetime that could get around relativity’s cosmic speed limits.
Wormholes are traditionally the stuff of science fiction, ranging from Jodie Foster’s wild ride in Contact to the time-bending plot twists in Interstellar. But the researchers behind the experiment, reported in the December 1 issue of the journal Nature, hope that their work will help physicists study the phenomenon for real.
“We found a quantum system that exhibits key properties of a gravitational wormhole, yet is sufficiently small to implement on today’s quantum hardware,” Caltech physicist Maria Spiropulu said in a news release. Spiropulu, the Nature paper’s senior author, is the principal investigator for a federally funded research program known as Quantum Communication Channels for Fundamental Physics.
Gridded Ion Thrusters (NEXT-C)
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Chat gpt 4 is wonderful but one thing it is lacking is sentience which could do all work for millions of years so essentially we would not need find all discoveries and all things by ourselves.
Richards said he originally wanted an AI agent to automatically email him daily AI news. But, as Motherboard, he realized in the process that existing LLMs struggle with “tasks that require long-term planning,” or are “unable to autonomously refine their approaches based on real-time feedback.” That understanding inspired him to create Auto-GPT, which, he said, “can apply GPT4’s reasoning to broader, more complex problems that require long-term planning and multiple steps.” (Richards didn’t respond for a request for an interview with Fast Company.)
“They get confused”
Autonomous agents, at this early stage, are mainly experimental. And they have some serious limitations that prevent them from getting what they want from large language models…
DJI has just unveiled its most advanced camera drone to date, but its hefty $16,500 price tag suggests it’s not for the everyday user.
Indeed, the new Inspire 3 is designed for professional moviemakers who want a powerful machine capable of nailing the best shots.
An update of the Inspire 2 that launched in 2016, the Inspire 3 sports a new streamlined design that offers improved mobility for complex maneuvers.
NAIROBI, April 14 (Reuters) — Kenya launched its first operational earth observation satellite on Saturday onboard a SpaceX rocket from the United States, a live feed from Elon Musk’s rocket company showed.
The satellite, developed by nine Kenyan engineers, will collect agricultural and environmental data, including on floods, drought and wildfires, that authorities plan to use for disaster management and to combat food insecurity.
The Falcon 9 rocket carrying the Taifa-1 satellite, took off at about 648 GMT without incident from Vandenberg Base in California, after three postponements due to bad weather.
Chinese President Xi Jinping called for an increase in combat training while visiting military forces, following China’s third day of drills in a show of force around Taiwan’s coast.