NVIDIA’s AI Blueprint combines Black Forest Labs’ FLUX.1-dev as an NVIDIA NIM microservice, ComfyUI and Blender in a prebuilt workflow optimized for RTX AI PCs.
The UK’s grid operator is investigating unexplained shifts in electricity frequency on Sunday
Power in Spain and Portugal has been mostly restored after a mass blackout paralysed most of the Iberian Peninsula.
Just over 92 per cent of Spain’s power is back, REE, the country’s electricity operator said early on Tuesday, and around 80 per cent of customers in Portugal are reported to have electricity.
Spain has declared a state of emergency in what is believed to be Europe’s largest power cut.
Periodic dietary restriction of animal products induces metabolic reprogramming in humans with effects on cardiometabolic health
Posted in biotech/medical, health | Leave a Comment on Periodic dietary restriction of animal products induces metabolic reprogramming in humans with effects on cardiometabolic health
Scientists led by Dr Claire Durrant (UK DRI at Edinburgh) have used living human brain tissue to show for the first time how a toxic form of a protein linked to Alzheimer’s can stick to and damage synapses, the connections between brain cells.
Fish are masters of coordinated motion. Schools of fish have no leader, yet individuals manage to stay in formation, avoid collisions, and respond with liquid flexibility to changes in their environment. Reproducing this combination of robustness and flexibility has been a long-standing challenge for human-engineered systems like robots.
Scientists have identified the neural circuitry responsible for assigning emotional value—positive or negative—to social encounters.
An international research team led by Professor Kiavash Movahedi from the Brussels Center for Immunology at the Vrije Universiteit Brussel has published unexpected results in the journal Immunity. Their study sheds new light on the possibility of effectively replacing defective microglia—the brain’s immune cells—marking a potential breakthrough in the treatment of neurodegenerative diseases such as Alzheimer’s and Parkinson’s.
Microglia are essential for healthy brain function. Defective microglia are increasingly linked to the development of neurodegenerative disorders.
“Microglia are unique,” says Prof. Movahedi. “They originate early in embryonic development and maintain themselves throughout life without being replaced by new cells from the blood. That makes them special, but also vulnerable.”
The Hopf whole-brain model, based on structural connectivity, overcomes limitations of traditional structural or functional connectivity-focused methods by incorporating heterogeneity parameters, quantifying dynamic brain characteristics in healthy and diseased states. Traditional parameter fitting techniques lack precision, restricting broader use. To address this, we validated parameter fitting methods using simulated networks and synthetic models, introducing improvements such as individual-specific initialization and optimized gradient descent, which reduced individual data loss. We also developed an approximate loss function and gradient adjustment mechanism, enhancing parameter fitting accuracy and stability.
