Lifeboat Foundation

Circa 2021 This article states that humans have possibly an untapped regeneration ability and they may have found it in mice.

Using new phospho-flow cytometry techniques to measure signaling in individual cell subsets we compared mouse to salamander inflammation. These studies demonstrated evolutionarily conserved responses to PAMP ligands through toll-like receptors (TLRs) but identified key differences in response to DAMP ligands. Co-exposure of macrophages to DAMPs/PAMPs suppressed MAPK signaling in mammals, but not salamanders, which activate sustained MAPK stimulation in the presence of endogenous DAMPS.

The main structure shaping the mouse digit tip in size and form is the terminal phalangeal bone (Fig. Supl. 1). As all long bones, the terminal phalanx is formed during embryonic development through endochondral ossification, resulting in longitudinal growth, and through the process of appositional ossification, resulting in peripheral growth¹³. Differently from all long bones, the length of the distal phalanx is further increased by an additional ossification center located at the distal tip of the bone, through intramembranous ossification^13,14. Estimations point that 55% of the postnatal elongation of the distal phalanx of mice is a consequence of this distal process¹³. One study showed that although distal amputation eliminates part of the terminal phalanx formed by endochondral ossification, bone regrowth after amputation is exclusively due to distal intramembranous ossification¹³. Similar to bone formation by intramembranous ossification during development or after injury¹⁶, bone regrowth after distal amputation of the mouse digit tip depends on Wnt signaling¹⁷.

Re-establishment of homeostasis and nail and bone regrowth are expected to occur naturally after digit tip lesions. However, the formation of a blastema, which is a hallmark of epimorphic regeneration in salamanders, has been largely discussed in mammals^{7,9,18,19,20,21,22}. The search for a mammalian blastema is sustained by the idea that, as in salamanders, tissue-specific cells, or stem/progenitor cells, would respond to the distal amputation lesion, migrating to a central distal-most region of the digit, creating the multi-tissue structure comprising the regenerating digit. A study in mice¹⁷ shows that as in salamanders, each tissue comprising the regenerated digit is formed by tissue-specific stem cells residing in the tissues preserved after amputation, suggesting that trans-differentiation does not occur in amputated mouse digit tip. However, it is not known whether these stem cells are integrating a regenerative blastema induced by the distal amputation or simply generating more tissue through endogenous tissue repair responses.

In this study, we compared digit regenerative capacity after distal and proximal amputation and propose a hypothetical mechanism by which digits are able to regain a morphology that is close to normal after distal amputations but fails when amputations are performed proximally. While most tissues re-establish homeostasis in very similar ways in distal and proximal amputated digits, bone growth is only observed after distal amputations. Observing the regions affected by each amputation plan, we propose that the main difference between these two amputation plans is the elimination of osteogenic signals and precursor cells in proximally amputated digits. In distally amputated digits, the source of osteogenic signal emanating from the nail¹⁷ and the presence of osteoprogenitor cells in the periosteum²³ could be sufficient to promote bone growth and give the digit a new tip.

Gravitational lensing of the cosmic microwave background has been used to probe the distribution of dark matter around some of the earliest galaxies in the Universe.

Investigating the properties of galaxies is fundamental to uncovering the still-unknown nature of the dominant forms of mass and energy in the Universe: dark matter and dark energy. Dark matter resides in “halos” surrounding galaxies, and information on the evolution of this invisible substance can be obtained by examining galaxies over a wide range of cosmic time. But observing distant galaxies—those at high redshifts—poses a challenge for astronomers because these objects look very dim. Fortunately, there is another way to probe the dark matter around such galaxies: via the imprint it leaves on the pattern of cosmic microwave background (CMB) temperature fluctuations through gravitational lensing (Fig. 1).

Most measurements of Newton’s gravity constant use stationary masses, but a new experiment measures the constant with wiggling metal beams.

Researchers at the University of Massachusetts Amherst recently announced that they have figured out how to engineer a biofilm that harvests the energy in evaporation and converts it to electricity. This biofilm, which was announced in Nature Communications, has the potential to revolutionize the world of wearable electronics, powering everything from personal medical sensors to personal electronics.

Researchers have reported the discovery of an exoplanet orbiting Ross 508 near the inner edge of its habitable zone.

Researchers at the University of Massachusetts Amherst recently announced that they have figured out how to engineer a biofilm that harvests the energy in evaporation and converts it to electricity. This biofilm, which was announced in Nature Communications, has the potential to revolutionize the world of wearable electronics, powering everything from personal medical sensors to personal electronics.

“This is a very exciting technology,” says Xiaomeng Liu, graduate student in electrical and computer engineering in UMass Amherst’s College of Engineering and the paper’s lead author. “It is real green energy, and unlike other so-called ‘green-energy’ sources, its production is totally green.”

Continue reading “Researchers engineer biofilm capable of producing long-term, continuous electricity from your sweat” »

Researchers have reported the discovery of an exoplanet orbiting Ross 508 near the inner edge of its habitable zone.

Researchers have uncovered a list of 3,207 mobile apps that are exposing Twitter API keys in the clear, some of which can be utilized to gain unauthorized access to Twitter accounts associated with them.

The takeover is made possible, thanks to a leak of legitimate Consumer Key and Consumer Secret information, respectively, Singapore-based cybersecurity firm CloudSEK said in a report exclusively shared with The Hacker News.

Continue reading “Researchers Discover Nearly 3,200 Mobile Apps Leaking Twitter API Keys” »

A 24-year-old Australian hacker has been charged with developing and selling the “Imminent Monitor” spy software to more than 14,500 people.

Critical Security Vulnerabilities In Netgear Business Routers Which The Netgear Team Can’t Fix. Stop Using These Routers As Soon As Possible — Vulnerabilities — Information Security Newspaper | Hacking News.

Vulnerabilities — information security newspaper | hacking news.

A Sentinel One investigation revealed threat actors (TA) have been abusing the Windows Defender command line tool to decrypt and load Cobalt Strike payloads.

The cybersecurity experts detailed their findings in an advisory last week, in which they said the TA managed to carry out the attacks after obtaining initial access via the Log4Shell vulnerability against an unpatched VMware Horizon Server.

The attackers reportedly modified the Blast Secure Gateway component of the application by installing a web shell using PowerShell code.