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Researchers have developed a fluorescence microscope that uses structured illumination for fast super-resolution imaging over a wide field of view. The new microscope was designed to image multiple living cells simultaneously with a very high resolution to study the effects of various drugs and mixtures of drugs on the body.

“Polypharmacy—the effect of the many combinations of drugs typically prescribed to the chronically sick or elderly—can lead to dangerous interactions and is becoming a major issue,” said Henning Ortkrass from Bielefeld University in Germany. “We developed this microscope as part of the EIC Pathfinder OpenProject DeLIVERy, which aims to develop a platform that can investigate polypharmacy in individual patients.”

In the journal Optics Express, the researchers describe their new microscope, which uses optical fiber delivery of excitation light to enable very high image quality over a very large field of view with multicolor and high-speed capability. They show that the instrument can be used to image , achieving a field of view up to 150 × 150 μm2 and imaging rates up to 44 Hz while maintaining a spatiotemporal resolution of less than 100 nm.

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Imec, a research and innovation hub in nanoelectronics and digital technologies, has presented the successful integration of a pinned photodiode structure in thin-film image sensors.

The report, published in the August 2023 edition of Nature Electronics, is titled “Thin-film image sensors with a pinned photodiode structure.” Initial results were presented at the 2023 edition of the International Image Sensors Workshop.

With the addition of a pinned-photogate and a transfer gate, the superior absorption qualities of thin-film imagers—beyond one µm wavelength—can finally be exploited, unlocking the potential of sensing light beyond the visible in a cost-efficient way.

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Quantum computers are the next step in computation. These devices can harness the peculiarities of quantum mechanics to dramatically boost the power of computers. Not even the most powerful supercomputer can compete with this approach. But to deliver on that incredible potential, the road ahead remains long.

Still, in the last few years, big steps have been taken, with simple quantum processors coming online. New breakthroughs have shown solutions to the major challenges in the discipline. The road is still long, but now we can see several opportunities along the way. For The Big Questions, IFLScience’s podcast, we spoke to Professor Winfried Hensinger, Professor of Quantum Technology at the University of Sussex and the Chief Scientific Officer for Universal Quantum, about the impact these devices will have.

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Stem cells have been used to produce organoids that release the proteins responsible for forming dental enamel, a substance that shields teeth from harm and decay. This initiative was led by a multi-disciplinary team of researchers from the University of Washington in Seattle.

“This is a critical first step to our long-term goal to develop stem cell-based treatments to repair damaged teeth and regenerate those that are lost,” said Hai Zhang, professor of restorative dentistry at the UW School of Dentistry and one of the co – authors of the paper describing the research.

The findings are published today in the journal Developmental Cell. Ammar Alghadeer, a graduate student in Hannele Ruohola-Baker’s laboratory in the Department of Biochemistry at the UW School of Medicine was the lead author on the paper. The lab is affiliated with the UW Medicine Institute for Stem Cell and Regenerative Medicine.

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One of Google’s AI units is using generative AI to develop at least 21 different tools for life advice, planning and tutoring, The New York Times reported Wednesday.

Google’s DeepMind has become the “nimble, fast-paced” standard-bearer for the company’s AI efforts, as CNBC previously reported, and is behind the development of the tools, the Times reported.

News of the tool’s development comes after Google’s own AI safety experts had reportedly presented a slide deck to executives in December that said users taking life advice from AI tools could experience “diminished health and well-being” and a “loss of agency,” per the Times.

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