Lifeboat Foundation

Could we describe and search for proof of technology originating from outside of Earth?

If an alien were to look at Earth, many human technologies — from cell towers to fluorescent light bulbs — could be a beacon signifying the presence of life.

We are two astronomers who work on the search for extraterrestrial intelligence — or SETI. In our research, we try to characterize and detect signs of technology originating from beyond Earth. These are called technosignatures. While scanning the sky for a TV broadcast of some extraterrestrial Olympics may sound straightforward, searching for signs of distant, advanced civilizations is a much more nuanced and difficult task than it might seem. iStock.

Scientists and materials researchers have invented a new and improved tool, “lab on a chip,” to measure light, according to a press release by Oregon State University (OSU) published on October 20.

An ultra-tiny device

The new tool consists of an ultra-tiny spectrometer that fits on a microchip and is operated using artificial intelligence. It now may lead to upgrades in everything from smartphone cameras to environmental monitoring.

E-scooters are all the rage in Türkiye, as their sales and number of companies renting them soared in recent years. Yet, they have several cons, like long charging times and possible pollution from the uncontrolled disposal of discarded batteries. Four Turkish engineers hope a new scooter, working on hydrogen power, may overcome these problems.

“Hebunk,” devised by entrepreneurs working at a technology park at Istanbul Technical University, boasts a fast charging time, just five minutes, and can travel for 60 kilometers (37.28 miles) with a single charge, which roughly costs about 9 cents (TL 1.8).

The scooter, which is not too different from e-scooters in appearance, was developed in one year by the entrepreneurs’ HydroBorPEM Fuel Cell Technologies, now based at a technology park in Istanbul’s Yıldız Technical University.

Technology is advancing so rapidly that it’s almost impossible to keep up with the ever-changing landscape of innovation. That’s why we’ve compiled the 50 most insane new scientific discoveries of the last decade into one epic video!

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To test the interaction between senolytic removal of senescent cells and cellular reprograming, we designed a model combining these two interventions in an inducible overexpression system in Drosophila. First, we used the four Yamanaka factor based OKSM approach as this had been previously shown to induce pluripotent stem cells in mice [7], humans [29 – 31] and non-mammalian vertebrate and invertebrate species [32]. To make a senolytic factor for Drosophila, we took advantage of the mouse sequence (FOXO4-DRI [22]) to design an orthologous peptide based on the Drosophila foxo (forkhead box, sub-group O) gene [33]. We then characterized effects of these two interventions independently as well as in combination.

We began by looking at the effect of OKSM and Sen on stem cells in an intestinal stem cell (ISC) model [34, 35]. We chose to investigate phenotypic effects specifically in the digestive system of Drosophila (Supplementary Figure 1). As in mammals, the Drosophila gastric lining has a high turnover of cells which is enabled by stem cell pools that replenish the epithelia [34]. Age-dependent loss of stem cells and degradation of barrier function has been shown to contribute to age-dependent functional decline and mortality in Drosophila [36]. The Drosophila gut is composed of four cell types: enterocytes (ECs or absorptive cells), enteroendocrine (EEs or secretory cells), enteroblasts (EBs or transit amplifying cells) and intestinal stem cells (ISCs).

When we think about aging, one of the first thoughts that comes to mind is wrinkled and sagging skin as well as the greying and loss of hair – simply put, the physical changes to appearance that we associated with advancing age. These changes are the most striking reflection of the underlying molecular aging processes that are happening inside our bodies.

The current size of the cosmetic industry alone highlights that physical appearance is important to people. As we continue developing strategies to improve longevity allowing us to live longer and in far better health, people will inevitably want a “youthful appearance” to match their newfound “youthful state”. Furthermore, as this report explains in more detail, aesthetic aging plays a significant and grossly underappreciated role in influencing the rate of biological aging.

It is fair to say that the cosmetic industry alone might not be enough to address aesthetic aging from a longevity point of view, as cosmetic products work to conceal the signs of aging. We need tactics that can address the underlying causes of skin and hair aging to achieve long-term benefits and halt the fine interlink between aesthetic aging and biological aging. This is where advanced aesthetics comes in.

Biotech company Mogling Bio has successfully has completed its first seed investment round with a sole investor, Kizoo Technology Capital.

Mogling Bio is developing new pharmacological approaches to rejuvenate old stem cells of the hematopoietic (blood cell formation) system.

Ageing causes stem cells to lose their normal structure by increased activity of the protein CDC42. Normalising CDC42 activity can restore structure, order and functionality in those aged stem cells.

Turn.bio has announced that its proprietary cellular reprogramming technology was able to significantly increase the proliferative and cytotoxic potential of premanufactured CAR-T cells in vitro.

Turn.bio, a developer of mRNA-based cellular reprogramming technologies, has announced preliminary results from its current trial. The announcement was made by the company’s co-founder, Prof. Vittorio Sebastiano, at the New Frontiers of RNA Nanotherapeutics conference at Houston Methodist Research Institute. These results show that the company’s proprietary Epigenetic Reprogramming of Aging (ERA) technology greatly increases the fitness of CAR-T cells, which are widely used in modern immunotherapy.

T cell exhaustion is a big problem.