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Earlier research by Dr. Li-Huei Tsai of the Massachusetts Institute of Technology and others found that APOE4 might raise Alzheimer’s risk by altering lipid metabolism in certain brain cells. But the underlying details of the process remained unclear.

To build on these findings, the team conducted a multi-pronged study that assessed gene activity of all major cell types in post-mortem human brain tissue from 32 men and women who had one, two, or no copies of the APOE4 gene. Results were published in Nature on November 24, 2022.

The researchers found that APOE4 affected gene expression across all measured cell types. The team then took a closer look at genes related to cholesterol and other lipids. Cholesterol-manufacturing genes were overly expressed, and cholesterol-transporting genes dysregulated, in brain cells called oligodendrocytes with the APOE4 gene. Oligodendrocytes are found in the brain and spinal cord. They make and maintain a fatty substance called myelin that surrounds and insulates long nerve fibers. The abnormalities were more extreme in oligodendrocytes with two copies of APOE4 rather than one.

AI gradually taking over coding. Coders tryin to circle the wagons, but its already too late. AI coders will be best in world in probably mid 2025.

Modern machine learning systems can achieve average human-level performance in popular competitive programming contests.

The risk of complications in assisted reproduction is higher when two embryos are transferred, instead of one embryo. This has been shown in a study published in the journal JAMA Pediatrics, which included all births in Sweden 2007–2017.

Fertility treatments using assisted reproduction in Sweden are among the safest in the world regarding risks for the mother and children. A national recommendation to only transfer one embryo in assisted reproduction was introduced in 2003, aiming to decrease the risk of multiple pregnancies and their related complications during pregnancy and delivery.

In certain cases, two embryos are still transferred in order to increase the chance of pregnancy while the risk of multiple pregnancy remains low. Thus, many of the treatments with double embryo transfer result in single pregnancies. Many patients wish to have two embryos transferred to increase their chances of pregnancy, but there is a lack of data on potential risks with transferring two embryos when the treatment results in the birth of a single child.

They only wanted to watch some k-dramas. 😢

Two teenagers in North Korea have been killed by a firing squad for watching and selling movies from neighbouring South Korea.

Cybercrime marketplaces are increasingly selling stolen corporate email addresses for as low as $2 to fill a growing demand by hackers who use them for business email compromise and phishing attacks or initial access to networks.

Analysts at Israeli cyber-intelligence firm KELA have closely followed this trend, reporting at least 225,000 email accounts for sale on underground markets.

The largest webmail shops are Xleet and Lufix, claiming to offer access to over 100k breached corporate email accounts, with prices ranging between $2 and $30, if not more, for highly-desirable organizations.

Data security — information security newspaper | hacking news.

Cancer, caused by abnormal overgrowth of cells, is the second-leading cause of death in the world. Researchers from the Salk Institute have zeroed in on specific mechanisms that activate oncogenes, which are altered genes that can cause normal cells to become cancer cells.

Cancer can be caused by genetic mutations, yet the impact of specific types such as structural variants that break and rejoin DNA, can vary widely. The findings, published in Nature on December 7, 2022, show that the activity of those mutations depends on the distance between a particular gene and the sequences that regulate the gene, as well as on the level of activity of the regulatory sequences involved.

Continue reading “Flipping the switch: Scientists shed new light on genetic changes that turn ‘on’ cancer genes” »

In initial tests, a simplified version of a popular superconducting qubit achieves high computation accuracies, making it attractive for future quantum computers.

Combustion engines, propellers, and hydraulic pumps are examples of fluidic devices—instruments that utilize fluids to perform certain functions, such as generating power or transporting water.

Because fluidic devices are so complex, they are typically developed by experienced engineers who manually design, prototype, and test each apparatus through an iterative process that is expensive, time-consuming, and labor-intensive. But with a new system, users only need to specify the locations and speeds at which fluid enters and exits the device. The computational pipeline then automatically generates an optimal design that achieves those objectives.

The system could make it faster and cheaper to design fluidic devices for all sorts of applications, such as microfluidic labs-on-a-chip that can diagnose disease from a few drops of blood or artificial hearts that could save the lives of transplant patients.