Lifeboat Foundation: Safeguarding Humanity
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Huge libraries of drug compounds may hold potential treatments for a variety of diseases, such as cancer or heart disease. Ideally, scientists would like to experimentally test each of these compounds against all possible targets, but doing that kind of screen is prohibitively time-consuming.

In recent years, researchers have begun using computational methods to screen those libraries in hopes of speeding up drug discovery. However, many of those methods also take a long time, as most of them calculate each target protein’s three-dimensional structure from its amino-acid.

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Researchers in Japan and Australia have developed a new multicore optic fiber able to transmit a record-breaking 1.7 petabits per second, while maintaining compatibility with existing fiber infrastructure. The team–from Japan’s National Institute of Information and Communications Technology (NICT) and Sumitomo Electric Industries, and Macquarie University in Sydney, Australia—achieved the feat using a fiber with 19 cores. That’s the largest number of cores packed into a cable with a standard cladding diameter of 0.125 micrometers.

“We believe 19 cores is the highest practical number of cores or spatial channels you can have in standard cladding diameter fiber and still maintain good quality transmission,” says Georg Rademacher, who previously headed the project for NICT but who has recently returned to Germany to take up a directorship in optical communications at the University of Stuttgart.

Most fiber cables for long-distance transmission in use today are single core, single-mode glass fibers (SMF). But SMF is approaching its practical limit as network traffic rapidly increases because of AI, cloud computing, and IoT applications. Many researchers are therefore taking an interest in multicore fiber in conjunction with space-division multiplexing (SDM), a transmission technique for using multiple spatial channels in a cable.

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Recent advances in cancer diagnosis, treatment, and management have resulted in a growing number of cancer survivors. Researchers constantly strive to understand new ways to support cancer survivors and help them lead a healthy and happy life post-treatment. This has led to our understanding that cancer survivors have different healthcare needs than their counterparts with no history of cancer.

One concern facing cancer survivors involves cardiovascular disease (CVD), a general term including conditions that inflict the heart or blood vessels. Many cancer survivors face a higher risk of dying from cardiovascular disease (CVD) than from cancer itself.

Despite the well-known adverse effects of tobacco use associated with both cancer and CVD, about 20% of cancer survivors continue smoking after diagnosis. How smoking cessation impacts CVD risk after cancer diagnosis remains poorly understood. To address this, a team of researchers recently published their study investigating the cardiovascular consequences of quitting smoking after a cancer diagnosis in the European Heart Journal.

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Some of the world’s leading human and robot minds are heading to the United Nations.

At a UN summit in Geneva next week, tech luminaries ranging from futurist Ray Kurzweil to DeepMind COO Lila Ibrahim will discuss AI for good. It’s a stellar lineup of speakers, but the real stars in our eyes are the robots.

Over 50 of the beasts — the majority from Europe — will be in attendance. All of them merit places in your dreams and nightmares, but we’ve narrowed the roster down to a list of our 10 favourites.

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Scientists using the Atacama Large Millimeter/submillimeter Array (ALMA) to study the protoplanetary disk around a young star have discovered the most compelling chemical evidence to date of the formation of protoplanets. The discovery will provide astronomers with an alternate method for detecting and characterizing protoplanets when direct observations or imaging are not possible. The results will be published in an upcoming edition of The Astrophysical Journal Letters.

HD 169,142 is a young star located in the constellation Sagittarius that is of significant interest to astronomers due to the presence of its large, dust-and gas-rich circumstellar disk that is viewed nearly face-on. Several candidates have been identified over the last decade, and earlier this year, scientists at the University of Liège and Monash University confirmed that one such candidate—HD 169,142 b—is, in fact, a giant Jupiter-like protoplanet.

The discoveries revealed in a new analysis of archival data from ALMA—an in which the National Science Foundation’s National Radio Astronomy Observatory (NRAO) is a member—may now make it easier for scientists to detect, confirm, and ultimately characterize, protoplanets forming around .

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We are currently recruiting Editorial Board Members (EBMs) and Topical Advisory Panel Members (TAPMs) for this Section. If you are an active researcher in this field and are passionate about publishing cutting-edge research, please contact us by email at [email protected].

Feature papers represent the most advanced research with significant potential for high impact in the field. A Feature Paper should be a substantial original Article that involves several techniques or approaches, provides an outlook for future research directions and describes possible research applications.

Feature papers are submitted upon individual invitation or recommendation by the scientific editors and must receive positive feedback from the reviewers.

Editor’s Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to readers, or important in the respective research area. The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal.

Continue reading “Recruiting Editorial Board Members and Topical Advisory Panel Members for Section “Mathematical Modelling and Numerical Simulation of Combustion and Fire”” | >

During the experiment, pluripotent stem cells – a special kind of stem cells that have the potential to grow into all major human cells – were brought into the Wentian lab module on the space station, where some of them successfully grew into hematopoietic stem cells – another kind of stem cells that produce blood cells.

Dozens of other science experiments were also conducted by the Shenzhou-15 crew during their stay at the China Space Station.

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Making headphones that work underwater can be a trivial challenge. Not only do they need to be fully waterproof and easy to control, but they cannot rely solely on Bluetooth — because this wireless technology doesn’t work reliably underwater. In fact, Bluetooth range underwater is reduced from as much as 240 meters (800 feet) to less than 8 cm (3 inches).

I love the power and versatility of my AirPods Pro. And I wear my Shocks OpenRun Pro bone conduction sports headphones when walking, hiking, and cycling because they don’t cut me off from my surroundings. But there’s been a gap in my headphone-wearing needs: swimming.

Not anymore!

Now, I have the H2O Audio Sonar Pro underwater headphones, and I can’t see myself bringing anything else to the next pool party.

Continue reading “These headphones make it possible to listen to music while swimming” | >

Here we address the important question of cross-talk between the mitochondria and cytosol. We show that the inner mitochondrial protein, MiNT, interacts with a protein on the outer mitochondrial membrane (mNT). This interaction occurs within the major outer membrane protein VDAC1. Inside the inner space of VDAC1, MiNT transfers its [2Fe-2S] clusters to mNT, which was shown to be a [2Fe-2S] cluster donor protein that donates its cluster(s) to apo-acceptor proteins residing in the cytosol. Hence, we suggest a pathway for transferring [2Fe-2S] clusters from inside the mitochondria to the cytosol.

Mitochondrial inner NEET (MiNT) and the outer mitochondrial membrane (OMM) mitoNEET (mNT) proteins belong to the NEET protein family. This family plays a key role in mitochondrial labile iron and reactive oxygen species (ROS) homeostasis. NEET proteins contain labile [2Fe-2S] clusters which can be transferred to apo-acceptor proteins. In eukaryotes, the biogenesis of [2Fe-2S] clusters occurs within the mitochondria by the iron–sulfur cluster (ISC) system; the clusters are then transferred to [2Fe-2S] proteins within the mitochondria or exported to cytosolic proteins and the cytosolic iron–sulfur cluster assembly (CIA) system. The last step of export of the [2Fe-2S] is not yet fully characterized. Here we show that MiNT interacts with voltage-dependent anion channel 1 (VDAC1), a major OMM protein that connects the intermembrane space with the cytosol and participates in regulating the levels of different ions including mitochondrial labile iron (mLI). We further show that VDAC1 is mediating the interaction between MiNT and mNT, in which MiNT transfers its [2Fe-2S] clusters from inside the mitochondria to mNT that is facing the cytosol. This MiNT–VDAC1–mNT interaction is shown both experimentally and by computational calculations. Additionally, we show that modifying MiNT expression in breast cancer cells affects the dynamics of mitochondrial structure and morphology, mitochondrial function, and breast cancer tumor growth. Our findings reveal a pathway for the transfer of [2Fe-2S] clusters, which are assembled inside the mitochondria, to the cytosol.

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