Lifeboat Foundation: Safeguarding Humanity
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Finding new drugs – called “drug discovery” – is an expensive and time-consuming task. But a type of artificial intelligence called machine learning can massively accelerate the process and do the job for a fraction of the price.

My colleagues and I recently used this technology to find three promising candidates for senolytic drugs – drugs that slow ageing and prevent age-related diseases.

Senolytics work by killing senescent cells. These are cells that are “alive” (metabolically active), but which can no longer replicate, hence their nickname: zombie cells.

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DISCLOSURE: Longevity. Technology (a brand of First Longevity Limited) has been contracted by the company featured in this article to support its current funding round. Qualifying investors can find out more via the Longevity. Technology investor portal.

British regenerative medicine company Videregen is on a mission to cure chronic diseases and is targeting the human immune system through its work to regenerate the thymus. Building on groundbreaking work conducted at the Francis Crick Institute, Videregen believes its technology holds the potential to restore the function of the aging immune system. The company is already approved for initial clinical trials of its technology in respiratory disease and is working towards trials of its regenerative thymus technology within three years.

Longevity Technology: The thymus is a small but important organ in the immune system and is responsible for the development and maturation of critical T cells. It plays a key role in our early development, but declines significantly as we age, along with the functionality of our immune system, and its decline is linked to several age-related and chronic diseases. Videregen is betting that its technology can help restore the thymus, potentially rejuvenating our immune system in the process. To learn more, we spoke to the company’s CEO, Dr Steve Bloor.

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A stem cell therapy treatment developed by Duke-NUS Medical School researchers for heart failure has shown promising results in preclinical trials. These cells, when transplanted into an injured heart, are able to repair damaged tissue and improve heart function, according to a study published in the journal npj Regenerative Medicine.

Longevity. Technology: The most common cause of death worldwide is ischemic heart disease, which is caused by diminished blood flow to the heart. When blood flow to the heart is blocked, the heart muscle cells die – a condition termed myocardial infarction or heart attack, something that happens to 805,000 people a year in the US [1].

In the Duke-NUS study, a unique new protocol was used where pluripotent stem cells were cultivated in the laboratory in order to grow into heart muscle precursor cells – these cardiomyocyte progenitors can develop into various types of heart cells, through a process called cell differentiation in which dividing cells gain specialised functions. During preclinical trials, the precursor cells were injected into the area of the heart damaged by myocardial infarction, where they were able to grow into new heart muscle cells, restoring damaged tissue and improving heart function.

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Managing Director of Cyber Security Consulting at Verizon.

It’s no surprise firewalls and encryption are instrumental to help defend against cyberattacks, but those tools can’t defend against one of the largest cybersecurity threats: people.

Social engineering—manipulating individuals to divulge sensitive information—is on the rise, even as organizations increasingly implement cybersecurity education and training. While social engineering already poses a challenge for organizations, AI might make it even more of a threat.

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May people worry that infectious pathogens will become resistant to current first-line therapies like antibiotics. Bacteria and other infectious diseases evolve and change to meet the needs of their environment and overcome treatments like these. Cancer is a well-known case in which the tumor cells evolve and become resistant to immunotherapy and other targeted treatments. Cancer is a prime example, because it rapidly divides and the mechanism by which it progresses allows tumor cells to avoid or overcome therapies. However, bacterial diseases are also common infections that can rapidly evolve. The World Health Organization (WHO) has even warned against a time in which antibiotics will not work. If this were the case, minor illnesses such as the common cold, could become fatal. The worry of antibiotic resistance is partly the reason we get yearly vaccinations. The Center for Disease Control (CDC) best predicts which viral infections will persist in the following year. A multitude of data is included in this prediction including the following:

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Influenza, or the “flu,” is a viral respiratory infection that commonly affects the nose, throat, and lungs. Some symptoms of flu infection include fever, muscle ache, headache, dry cough, shortness of breath, general malaise, and more. Most healthy people with active flu infections can fight off the infection with their immune systems, however, certain high-risk groups may be prone to developing complications, such as children under 2 years old, adults over 65 years old, those that are pregnant, those with weakened immune systems, those with chronic illnesses, and those with a body mass index of 40 or higher.

The influenza vaccine is a preventative vaccine that reduces the chances of a patient having severe complications from the virus. Even after preventative measures such as the influenza vaccine, some adults remain at high risk for hospitalization following an infection. That is where flu antiviral drugs come in; antiviral drugs are medications that assist your body in fighting viruses.

The most common antiviral for the flu is Tamiflu, generically known as oseltamivir. Oseltamivir is a neuraminidase inhibitor and was approved by the United States Food and Drug Administration in 1999. When oseltamivir is started within two days of flu symptoms and confirmed flu infection, it can shorten length of illness along with a decrease in overall symptoms. This is especially useful in high-risk populations who may be able to prevent a hospitalization after taking oseltamivir.

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