An Opinion Response to, “If Simulated Fire Can’t Burn Wood, How Can a Simulation Really Think, Feel or be Conscious?” by Michael Ulrich.
Carboncopies attended the Future of Neurotechnology With: Human Intelligence + Artificial Intelligence open discussion with Bryan Johnson and David Eagleman. A picture at our annual Whole Brain Emulation dinner in San Diego. Randal and Jevon after the discussion.
Ray Kurzweil is an author, computer scientist, inventor, futurist and a director of engineering at Google. Kurzweil is a public advocate for the futurist and transhumanist movements, and gives public talks to share his optimistic outlook on life extension technologies and the future of nanotechnology, robotics, and biotechnology.
Recorded 2013
The announcement comes from the journal Science, which published Phase 1 results of a small clinical trial for a vaccine technology that aims to cause the body to create a rare kind of cell.
“At the most general level, the trial results show that one can design vaccines that induce antibodies with pre-specified genetic features, and this may herald a new era of precision vaccines,” William Schief, PhD, a researcher at The Scripps Research Institute and study co-author, told the American Association for the Advancement of Science (AAAS).
The study was the first to test the approach in humans and was effective in 97% – or 35 of 36 – participants. The vaccine technology is called “germline targeting.” Trial results show that “one can design a vaccine that elicits made-to-order antibodies in humans,” Schief said in a news release.
Intel released nine research papers at IEDM 2022 that lay the groundwork for future chip designs as the company looks to deliver on its promise of developing processors with over a trillion transistors by 2030.
The research includes new 2D materials for transistors, new 3D packaging technology that narrows the performance and power gap between chiplet and single-die processors to a nearly-imperceptible range, transistors that ‘don’t forget’ when power is removed, and embedded memories that can be stacked directly on top of transistors and store more than one bit per cell, among other innovations.
Tiny antenna-like organelles once thought to be holdovers from our ancient past appear to play a crucial role in keeping track of time, according to a recent study on mice by researchers from the University of California, Irvine (UCI), in the US. Known as cilia, the microtubule projections can be found throughout the more complex branches of the tree of life, including on many of our own cells.
Aging inevitably increases the risk of disease, as exemplified by CAD, AD, and cancer. Monitoring the aging process and understanding its mechanisms will not only enhance early diagnoses, it may also provide strategies for the early prevention and treatment of diseases. While biomarkers for cellular senescence in in vitro cultured mammalian cells are already well-defined, those that define in vivo senescence/aging at the systemic level remain scarce. Here, we generated a targeted Glb1+/m allele at the Glb1 locus that encodes β-galactosidase. The GAC signal indicates Glb1 level. The results reveal that the live-imaged GAC signal is linearly correlated with chronological age, but only in middle-aged mice (9–13 months). High GAC at the MA stage was associated with cardiac hypertrophy and shortened lifespan. Moreover, GAC signal was exponentially increased in pathological lung fibrosis induced by BLM. Thus, this in vivo reporter mouse can faithfully monitor systemic aging and organ functional decline in a manner closely associated with lifespan, and provides an ideal system for studying aging mechanisms and developing anti-aging manipulations.
The upregulation of p16Ink4a transcription and elevated SAβ-gal staining are both well-established and widely used biomarkers for cellular senescence17, and the former led to the generation of live-imaging aging reporter mice20,22,23. Intriguingly, high level of p16Ink4a, indicated by luciferase activity, predicts cancer initiation rather than lifespan. Similarly, the in vivo application of SAβ-gal as a senescence marker at the tissue level is also limited. Positive SAβ-gal-staining is easy to obtain in kidney and adipose tissue sections but difficult to obtain in blood vessel and heart sections. By SAβ-gal staining, not many positive cells were detected in old individuals26. It raises the question of whether SAβ-gal labels in vivo senescence or if the percentage of in vivo senescent cells is indeed very low.
In a study from Cedars-Sinai, scientists suggest irritable bowel syndrome (IBS), the most common gastrointestinal disorder, may be caused by gravity. They explain that IBS—and many other conditions—could result from the body’s inability to manage gravity. The hypothesis describes how the intestines, spine, heart, nerves and brain evolved to manage gravity.
Do look up.
Scientists have come up with a new method to find dark matter based on a technique that picks up on meteor signatures.
‘Pangeos’ is a turtle-shaped ‘terayacht,’ a giant floating city imagined by Italian firm Lazzarini Design Studio. While it only exists as a rendering for now, upon completion it could be the largest floating structure in the world. #yahoofinance.
Don’t Miss: Valley of Hype: The culture that built Elizabeth Holmes.
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