Lifeboat Foundation

What’s your favorite ice cream flavor? You might say vanilla or chocolate, and if I asked why, you’d probably say it’s because it tastes good. But why does it taste good, and why do you still want to try other flavors sometimes? Rarely do we ever question the basic decisions we make in our everyday lives, but if we did, we might realize that we can’t pinpoint the exact reasons for our preferences, emotions, and desires at any given moment.

Most AI systems are black box models, which are systems that are viewed only in terms of their inputs and outputs. Scientists do not attempt to decipher the “black box,” or the opaque processes that the system undertakes, as long as they receive the outputs they are looking for.

A recent study to be presented at the American Heart Association (AHA) Scientific Sessions 2022 revealed unexpected changes in the electrical conduction system of the first genetically-modified porcine-to-human heart xenotransplant.

Xenotransplantation is the procedure of transplantation/implantation into a human of organs from non-human animal sources. The first pig-to-human heart xenograft was transplanted in January 2022 at the University of Maryland. The recipient survived for 61 days after receiving the xenograft. Research efforts have been underway for this xenotransplantation for over three decades.

Harvesting genetically-modified porcine hearts, the genes of which have been altered for safe transplantation into humans, would become a reality if successful. However, xenotransplantation of organs into a human carries several inherent challenges. With these transplant procedures, there is always the risk of graft rejection, infection, and abnormal heart rhythms.

An exploration of the question of whether it’s possible for Earth to have been visited by aliens long before humans appeared on this world? Would we even know about it if they did? Those questions are tackled in this video.

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Continue reading “Could Aliens Have Visited Earth in the Distant Past?” »

Up until recently, artificial intelligence was unable to perform such creative-looking tasks.

But all of that is beginning to change thanks to AI Sketch software like DreamStudio, Dall-E 2, and Stable Diffusion, which take a few keywords via a text interface to generate an image in a process known as “generative AI.”

Continue reading “AI Just Got More Creative, and Filmmakers Shouldn’t Be Afraid” »

Atmospheric warming is causing permafrost to melt — Part One of a Two-Part Look at the Problem and Challenges That Lie Ahead.

Canada has plans to reduce methane emissions from fossil fuel operations and orphan wells, but emissions from permafrost melt, not so much.

A team of Canadian researchers from Université de Montréal has designed and validated a new class of drug transporters made of DNA that are 20,000 times smaller than a human hair and that could improve how cancers and other diseases are treated.

Reported in a new study in Nature Communications, these molecular transporters can be chemically programmed to deliver optimal concentration of drugs, making them more efficient than current methods.

Bacterial biofilm formation is a huge problem in industry and medicine. Therefore, the discovery of anti-biofilm agents may hold great promise. Biofilm formation is usually a consequence of bacterial cell–cell communication, a process called quorum sensing (QS). CeO2 nanocrystals (NCs) have been established as haloperoxidase (HPO) mimics and ecologically beneficial biofilm inhibitors. They were suggested to interfere with QS, a mechanism termed quorum quenching (QQ), but their molecular mechanism remained elusive. We show that CeO2 NCs are effective QQ agents, inactivating QS signals by bromination. Catalytic bromination of 3-oxo-C12-AHL a QS signaling compound used by Pseudomonas aeruginosa, was detected in the presence of CeO2 NCs, bromide ions, and hydrogen peroxide. Brominated acyl-homoserine lactones (AHLs) no longer act as QS signals but were not detected in the bacterial cultures.

Measuring the mechanical interplay between cells and their surrounding microenvironment is vital in cell biology and disease diagnosis. Most current methods can only capture the translational motion of fiduciary markers in the deformed matrix, but their rotational motions are normally ignored. Here, by utilizing single nitrogen-vacancy (NV) centers in nanodiamonds (NDs) as fluorescent markers, we propose a linear polarization modulation (LPM) method to monitor in-plane rotational and translational motions of the substrate caused by cell traction forces. Specifically, precise orientation measurement and localization with background suppression were achieved via optical polarization selective excitation of single NV centers with precisions of ∼0.5°/7.5 s and 2 nm/min, respectively.